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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Microtubule-associated protein 1 light chain 3 beta

The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Beclin 1, LC3, V1a, PrP, CAN
Papers using LC3B antibodies
Association of RB/p16-pathway perturbations with DCIS recurrence: dependence on tumor versus tissue microenvironment
Lisanti Michael P. et al., In Cell Cycle, 2010
... #ab55176); p53 (Ab-6; Calbiochem, #OP43); Cathepsin B (FL-339) (Santa Cruz, #sc-13985); Lamp-1 (E-5) (Santa Cruz, #sc-17768); LC3B (Abcam, #ab48394); legumain (Santa Cruz, ...
Kdo2-Lipid A, a TLR4-specific Agonist, Induces de Novo Sphingolipid Biosynthesis in RAW264.7 Macrophages, Which Is Essential for Induction of Autophagy*
Merrill Alfred H. et al., In The Journal of Biological Chemistry, 2009
... to SPT1 (anti-LCB1), anti-BiP/GRP78, and anti-GM130 (BD Biosciences); rabbit monoclonal anti-HA tag and rabbit polyclonal LC3B antibody (Cell Signaling Technology, Boston); mouse monoclonal ...
Regulation of autophagy in mammals and its interplay with apoptosis
Boyano María D. et al., In Apoptosis, 2009
... (phospho S139), mouse monoclonal antibody anti-p21, mouse monoclonal antibody anti-Noxa, and rabbit polyclonal antibody to LC3B were from Abcam (Cambridge, UK) ...
Autophagy inhibits reactive oxygen species-mediated apoptosis via activating p38-nuclear factor-kappa B survival pathways in oridonin-treated murine fibrosarcoma L929 cells.
Kelly Kathleen A., In PLoS ONE, 2008
... anti-human caspase-1 p10 (sc515) antibody was purchased from Santa Cruz Biotechnologies (Santa Cruz, CA); anti-human/mouse LC3B antibody (NB600-1384) was purchased from Novus Biologicals (Cambridge, UK); anti-human total ...
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Dieli Francesco, In PLoS ONE, 2008
... Anti-LC3B antibody was from Abcam Inc ...
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Papers on LC3B
Reduction in Autophagy by (-)-Epigallocatechin-3-Gallate (EGCG): a Potential Mechanism of Prevention of Mitochondrial Dysfunction After Subarachnoid Hemorrhage.
Zhou et al., Xinxiang, China. In Mol Neurobiol, Feb 2016
Subsequently, EGCG can restore the disrupted autophagy flux after SAH both at the initiation and formation stages by regulating Atg5, LC3B, and Becn-1 (Beclin-1) mRNA expressions.
Establishment of two mouse models for CEDNIK syndrome reveals the pivotal role of SNAP29 in epidermal differentiation.
Emmert et al., Göttingen, Germany. In J Invest Dermatol, Jan 2016
We also found increased LC3B-II levels, unchanged p62/SQSTM1 protein amounts and a strong induction of the ER stress marker CHOP (C/EBP homologous protein) in mutant mice.
Detection of Autophagy in Caenorhabditis elegans Using GFP::LGG-1 as an Autophagy Marker.
Meléndez et al., New York City, United States. In Cold Spring Harb Protoc, Dec 2015
In yeast and mammalian cells, the autophagy protein Atg8/LC3 (microtubule-associated proteins 1A/1B light chain 3B encoded by MAP1LC3B) has been the marker of choice to detect double-membraned autophagosomes that are produced during the process of autophagy.
Interleukin-22 Alleviated Palmitate-Induced Endoplasmic Reticulum Stress in INS-1 Cells through Activation of Autophagy.
Zhang et al., Guangzhou, China. In Plos One, Dec 2015
The protein expression of glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), microtubule-associated protein light chain 3B (LC3B) and Bcl-2-interacting myosin-like coiled-coil protein (Beclin-1) were evaluated by western blot.
Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis.
Nanjundan et al., Tampa, United States. In Cell Death Dis, Dec 2015
However, we noted that protein expression of LC3B (microtubule-associated protein 1 light-chain 3β; an autophagic marker) was increased in uterine horns of endometriosis-induced mice compared with uterine horns of controls.
A potent betulinic acid analogue ascertains an antagonistic mechanism between autophagy and proteasomal degradation pathway in HT-29 cells.
Das et al., Calcutta, India. In Bmc Cancer, Dec 2015
In addition, 2c was found to alter expression levels of different autophagic proteins like Beclin-1, Atg 5, Atg 7, Atg 5-Atg 12, LC3B and autophagic adapter protein, p62.
Autophagic response to cell culture stress in pluripotent stem cells.
Moore et al., Sheffield, United Kingdom. In Biochem Biophys Res Commun, Oct 2015
In human embryonic stem cells (hESCS), autophagy was investigated by transfection of LC3-GFP to visualize autophagosomes and with an antibody to LC3B protein.
Flow cytometric assays for the study of autophagy.
Warnes, London, United Kingdom. In Methods, Aug 2015
These include the detection of the autophagy marker, the microtubule associated protein LC3B, cell cycle analysis of LC3B expression, increase in lysosomal mass, as well as organelle specific autophagy and the measurement of mitochondrial function.
Dual function of CALCOCO2/NDP52 during xenophagy.
Faure et al., Lyon, France. In Autophagy, 2014
Indeed, to mediate autophagosome maturation CALCOCO2 binds on the one hand to LC3A, LC3B, or GABARAPL2, and on the other hand to MYO6/MYOSIN VI, whereas the interaction with LC3C is dispensable.
Diverting autophagic membranes for exocytosis.
Münz et al., Zürich, Switzerland. In Autophagy, 2014
We have recently shown that the Epstein Barr virus (EBV) incorporates the autophagic membrane label LC3B-II into mature virus particles.
The role of autophagy as a mechanism of toxicity induced by multi-walled carbon nanotubes in human lung cells.
Haniu et al., Nagasaki, Japan. In Int J Mol Sci, 2014
Our recent study suggests that the levels of autophagy-related genes (LC3B) and autophagosome formation are clearly up-regulated, along with an increase in numbers of autophagosome vacuoles.
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
Czyzyk-Krzeska et al., Cincinnati, United States. In Cancer Cell, 2014
Here we establish, using shRNAs, a dominant-negative mutant, and a pharmacologic inhibitor, mefenamic acid (MFA), that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes the growth of clear cell renal cell carcinoma (ccRCC) and stimulates MAP1LC3A (LC3A) and MAP1LC3B (LC3B) autophagy.
VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma.
Czyzyk-Krzeska et al., Cincinnati, United States. In Cancer Cell, 2012
Here, using human ccRCC specimens, VHL-deficient cells, and xenograft models, we show that miR-204 is a VHL-regulated tumor suppressor acting by inhibiting macroautophagy, with MAP1LC3B (LC3B) as a direct and functional target.
Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death.
Choi et al., Boston, United States. In Am J Respir Cell Mol Biol, 2012
The interaction of LC3B and Fas pathways requires cav-1.LC3B plays a regulatory role in hyperoxia-induced epithelial apoptosis
[Effects of TFDP3 on regulating the autophagy and apoptosis of LNCaP cells].
Hao et al., Xi'an, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2012
Data show that TFDP3 upregulates the expression of autophagy gene LC3B and inhibits E2F1-induced apoptosis, and may play an important role in prostate cancer.
Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome.
Pawelek et al., New Haven, United States. In Clin Cancer Res, 2012
In solid tumors, high LC3B expression was associated proliferation, invasion and metastasis, high nuclear grade, and worse outcome.
Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan.
Jendrach et al., Frankfurt am Main, Germany. In Autophagy, 2012
These data relate LC3B, ATG5 and ATG12 to mitochondrial quality control after oxidative damage, and to cellular longevity.
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling.
Frame et al., Edinburgh, United Kingdom. In Nat Cell Biol, 2012
Autophagic targeting of active Src is associated with a Src-LC3B complex, and is mediated by c-Cbl.
Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.
Choi et al., Boston, United States. In Am J Respir Crit Care Med, 2011
The results suggest that autophagic protein LC3B exerts a protective function during the pathogenesis of pulmonary hypertension
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.
Choi et al., Boston, United States. In Nat Immunol, 2011
Here we demonstrate that depletion of the autophagic proteins LC3B and beclin 1 enhanced the activation of caspase-1 and secretion of interleukin 1β (IL-1β) and IL-18.
More papers using LC3B antibodies
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
Jiang C-Y et al., In Cell Death & Disease, 2007
... Phospho-mTOR (Ser2481), mTOR, phospho-S6, S6, phospho-AKT (Ser473), AKT and LC3B antibodies were purchased from Cell Signaling Technology (Boston, MA, USA) ...
The association between statins and cancer incidence in a veterans population
Aboussekhra Abdelilah, In PLoS ONE, 2007
... Anti-ATM-Ser1981 (Epitomics), anti-ATM (2C1) (Gene Tex), anti-γ-H2AX (Ser139) (Millipore), anti-LC3B (Abcam), anti-phospho-p53 (Ser15) (Cell Signaling ...
The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores.
Blagosklonny Mikhail V., In PLoS ONE, 2006
... Anti-LC3B antibody was purchased from Novus Biologicals (Littleton, CO) and anti-BECN1 ...
Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin.
Vij Neeraj, In PLoS ONE, 2006
... The following primary antibodies were used: monoclonal anti-p62 (Cell Signaling), rabbit anti-LC3B (Cell Signaling), mouse monoclonal anti-p97/VCP (Affinity ...
Prostaglandin J2 alters pro-survival and pro-death gene expression patterns and 26 S proteasome assembly in human neuroblastoma cells
Saikumar Pothana et al., In Oncogene, 2005
... MAP1 LC3B antibody was also obtained from Cell Signaling (Danvers, MA) ...
The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases
Gottlieb Roberta A. et al., In Journal of Cardiovascular Translational Research, 2003
... The blots were then incubated with 200-fold diluted primary antibodies against LC3B-II (Cell Signaling Technology, Beverly, MA, USA) ...
Rapid production of retroviruses for efficient gene delivery to mammalian cells using 293T cell-based systems.
Damania Blossom, In PLoS Pathogens, 2000
... (16B12, Covance Inc.), HA (3F10, Roche), NF-κB p65 (F-6, Santa Cruz, or C22B4, Cell Signaling), LC3B (D11, Cell signaling), IE1 antibody (CROMA101; provided ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... Signaling Technology), anti-Caspase-9 (1:500, #9504, Cell Signaling Technology), anti-Cleaved Caspase-9 (1:250, #9509, Cell Signaling Technology), anti-LC3B (1:500, ab48394, Abcam, Cambridge, UK), anti-HIF-1 ...
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