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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Microtubule-associated protein 1 light chain 3 alpha

LC3, Annexin A3, microtubule-associated protein 1 light chain 3
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: V1a, Beclin 1, CAN, mTOR, PrP
Papers using LC3 antibodies
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Lotze Michael T. et al., In The Journal of Cell Biology, 2009
... The antibody to LC3 was purchased from Novus Biologicals or AnaSpec ...
ADP mediates inhibition of insulin secretion by activation of P2Y13 receptors in mice.
Beaudoin Claude, In PLoS ONE, 2009
... The LC3 polyclonal antibody was purchased from MBL International (Woburn, MA) ...
Transcriptomic analysis of mild hypothermia-dependent alterations during endothelial reperfusion injury.
Cheriyath Venugopalan, In PLoS ONE, 2009
... Anti-light 1 chain 3 (anti-LC3) was from MBL International Operation; anti-p53 and ...
The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy
Holzbaur Erika L.F. et al., In The Journal of Cell Biology, 2009
... GFP-LC3 transgenic mice, strain name B6.Cg-Tg(CAG-EGFP/LC3)53Nmi/NmiRbrc, ...
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation.
Ramakrishnan Lalita, In PLoS Pathogens, 2008
... The ID4B rat monoclonal LAMP-1 antibody was from BD Biosciences (San Jose, CA) and the LC3 antibody was from Novus Biologicals (Littleton, CO) ...
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Papers on LC3
Mesenchymal Stem Cells Alleviate LPS-Induced Acute Lung Injury in Mice by MiR-142a-5p-Controlled Pulmonary Endothelial Cell Autophagy.
You et al., Taizhou, China. In Cell Physiol Biochem, Feb 2016
Mouse PECs were isolated by flow cytometry based on CD31 expression and then analyzed for autophagy-associated factors LC3 and Beclin-1 by Western blot.
Lipid Geometry and Bilayer Curvature Modulate LC3/GABARAP-Mediated Model Autophagosomal Elongation.
Alonso et al., Bilbao, Spain. In Biophys J, Feb 2016
Here, we used two minimal reconstituted systems (enzymatic and chemical conjugation) to compare the ability of human ATG8 homologs (LC3, GABARAP, and GATE-16) to mediate membrane fusion.
Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade.
Snyder et al., Baltimore, United States. In Proc Natl Acad Sci U S A, Feb 2016
In brain cultures, cocaine markedly increases levels of LC3-II and depletes p62, both actions characteristic of autophagy.
Recent progress in therapeutic strategy for ischemic stroke.
Abe et al., In Cell Transplant, Feb 2016
GDNF and HGF significantly reduced infarct size, the number of microtubule-associated protein 1 light chain3 (LC3)-positive cells, and the number of terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick end labeling (TUNEL)-positive cells, indicating that GDNF and HGF were greatly associated with not only the antiapoptotic effect but also the antiautophagic effects.
Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver.
Singh et al., United States. In Cell Metab, Feb 2016
Unexpectedly, the autophagosome marker LC3 is mechanistically coupled to ATGL-mediated lipolysis.
Ubiquitin-Dependent And Independent Signals In Selective Autophagy.
Dikic et al., Frankfurt am Main, Germany. In Trends Cell Biol, Jan 2016
Autophagy receptors bind to LC3/GABARAP proteins on phagophore and autophagosome membranes, and recognize signals on cargoes to deliver them to autophagy.
Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection.
Stallings et al., Saint Louis, United States. In Nature, Jan 2016
The involvement of autophagy has been defined based on studies in cultured cells where M. tuberculosis co-localizes with autophagy factors ATG5, ATG12, ATG16L1, p62, NDP52, BECN1 and LC3 (refs 2-6), stimulation of autophagy increases bacterial killing, and inhibition of autophagy increases bacterial survival.
Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis.
Sun et al., Guangzhou, China. In Plos One, Dec 2015
The induction of autophagy was supported by the accumulation of acidic vesicular organelles and autolysosomes, and the expression of autophagy-associated proteins, including microtubule-associated protein II light chain 3 (LC3-II), beclin-1, and autophagocytosis-associated protein (Atg)3.
Autophagy in colorectal cancer: An important switch from physiology to pathology.
Gheonea et al., Craiova, Romania. In World J Gastrointest Oncol, Dec 2015
Autophagy studies in CRC have focused on several molecules, mainly microtubule-associated protein 1 light chain 3, beclin 1, and autophagy related 5, with conflicting results.
Autophagy mediates degradation of nuclear lamina.
Berger et al., Philadelphia, United States. In Nature, Dec 2015
The autophagy protein LC3/Atg8, which is involved in autophagy membrane trafficking and substrate delivery, is present in the nucleus and directly interacts with the nuclear lamina protein lamin B1, and binds to lamin-associated domains on chromatin.
Decorin as a multivalent therapeutic agent against cancer.
Iozzo et al., Philadelphia, United States. In Adv Drug Deliv Rev, Nov 2015
Upon receptor binding, decorin initiates signaling pathways within endothelial cells downstream of VEGFR2 that ultimately culminate in a Peg3/Beclin 1/LC3-dependent autophagic program.
Atg7 in development and disease: panacea or Pandora's Box?
Xiong, Bethesda, United States. In Protein Cell, Oct 2015
Atg7 acts as an E1-like activating enzyme facilitating both microtubule-associated protein light chain 3 (LC3)-phosphatidylethanolamine and ATG12 conjugation.
Autophagic response to cell culture stress in pluripotent stem cells.
Moore et al., Sheffield, United Kingdom. In Biochem Biophys Res Commun, Oct 2015
In human embryonic stem cells (hESCS), autophagy was investigated by transfection of LC3-GFP to visualize autophagosomes and with an antibody to LC3B protein.
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy.
Youle et al., Bethesda, United States. In Nature, Sep 2015
Once recruited to mitochondria, NDP52 and optineurin recruit the autophagy factors ULK1, DFCP1 and WIPI1 to focal spots proximal to mitochondria, revealing a function for these autophagy receptors upstream of LC3.
Rubicon swaps autophagy for LAP.
Randow et al., Cambridge, United Kingdom. In Nat Cell Biol, Jul 2015
Phagocytic cells engulf their prey into vesicular structures called phagosomes, of which a certain proportion becomes demarcated for enhanced maturation by a process called LC3-associated phagocytosis (LAP).
Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases.
Wakabayashi et al., Hirosaki, Japan. In Neurosci Lett, 2012
Autophagy-related LC3 protein is not involved in the formation/degradation of neuronal intranuclear inclusions in neurodegenerative diseases.
Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages.
Shi et al., United States. In J Immunol, 2012
The effect of chronic infection with Heligmosomoides polygyrus on autophagy is associated with decreased expression and processing of LC3, a key component of the autophagic machinery.
Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy.
Gustafsson et al., San Diego, United States. In J Biol Chem, 2012
Bnip3 induced removal of both ER (ERphagy) and mitochondria (mitophagy) via autophagy. The clearance of these organelles was mediated in part via binding of Bnip3 to LC3 on the autophagosome.
Reduced expression of microtubule-associated protein 1 light chain 3 in hypertrophic scars.
Tang et al., Xi'an, China. In Arch Dermatol Res, 2012
The results suggested that the biosynthesis of microtubule-associated protein 1 light chain 3 is interrupted in hypertrophic scars.
Daunorubicin therapy is associated with upregulation of E3 ubiquitin ligases in the heart.
Engelbrecht et al., Stellenbosch, South Africa. In Exp Biol Med (maywood), 2012
daunorubicin-induced cardiac cytotoxicity is associated with upregulation of the E3 ligases, MURF-1 and MAFbx and also caused significant increases in two markers of autophagy, beclin-1 and LC3
More papers using LC3 antibodies
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans
Johansen Terje et al., In The Journal of Cell Biology, 2008
... monoclonal antibodies (BD); anti-GST rabbit polyclonal and anti–c-myc mouse monoclonal antibodies (Santa Cruz Biotechnology, Inc.); anti-LC3 rabbit polyclonal antibody (Cell Signaling Technology); anti-GFP rabbit polyclonal ...
Aging: past, present and future
Lisanti Michael P. et al., In Cell Cycle, 2008
... Biologicals, #NBP1–00085); BNIP3 (Abcam, #ab10433); Cathepsin B (FL-339) (Santa Cruz, #sc-13985); Lamp-1 (E-5) (Santa Cruz, #sc-17768); LC3 (Abcam, ab48395); ATG16L1 (Abgent, #AP1817a); ...
Interaction of polyphenols with proteins: binding of (−)-epigallocatechin gallate to serum albumin, estimated by induced circular dichroism
Sun Shi-Yong, In PLoS ONE, 2008
... (PARP), anti-caspase-3 and anti-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from Cell Signaling, anti-β-actin and anti-microtubule-associated protein 1 light chain 3 (LC3) from Sigma-Aldrich, anti-p62 from Abnova, anti-Atg5, anti-cathepsin D and anti-lysosome-associated ...
LPS-induced autophagy is mediated by oxidative signaling in cardiomyocytes and is associated with cytoprotection
Kanthasamy Arthi et al., In Parkinson's Disease, 2008
... Antibodies against LC3, 3-nitrotyrosine and 4-hydroxynonenal were obtained from Abcam, Inc., Cambridge, MA ...
The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells.
Dryer Stuart E., In PLoS ONE, 2008
... Anti-LC3 was purchased from Novus Biologicals, LLC (Novus Biologicals, Littleton, ...
Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
Carlin Cathleen R. et al., In The Journal of Cell Biology, 2007
... Gruenberg, University of Geneva, Geneva, Switzerland), LC3 mouse mAb (MBL), LC3 rabbit pAb (Abgent), ...
Autophagy fights disease through cellular self-digestion
Wang Fen et al., In International Journal of Biological Sciences, 2007
... (Danvers, MA); human LC3 (1:500) from Novus Biologicals, LLC (Littleton, CO); and ...
Autophagy-induced tumor dormancy in ovarian cancer.
Najbauer Joseph, In PLoS ONE, 2007
... Rabbit anti-light-chain 3 (LC3) polyclonal antibody was purchased from MBL International Corporation (Woburn, MA, ...
The blood-brain barrier in health and chronic neurodegenerative disorders
Brito Maria A. et al., In Frontiers in Cellular Neuroscience, 2007
... Rabbit anti-caveolin-1, rabbit anti-microtubule-associated protein 1 light chain-3 (LC3), LumiGLO, and cell lysis buffer were acquired from Cell Signaling (Beverly, MA, USA) ...
Metal Cu(II) and Zn(II) bipyridyls as inhibitors of lactate dehydrogenase.
Ma Jiyan, In PLoS ONE, 2007
... LC3 antibody was obtained from Cell Signaling Technology (Cat ...
Cardiac autophagy is a maladaptive response to hemodynamic stress
Zong Wei-Xing et al., In The Journal of Cell Biology, 2006
... GFP-LC3 transgenic mice ( ...
Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity
Chen Chin-Tin et al., In Molecular Cancer, 2005
... Monoclonal antibody that recognizes both forms of LC3 was purchased from MBL International Cooperation (Woburn, MA, ...
Cellular targets of gefitinib.
Zhang Lin, In PLoS ONE, 2004
... The Primary antibodies were antibodies against microtubule-associated protein 1 light chain 3 (LC3) (Cell Signaling Technology, #2775), ATG5 (Cell ...
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
Ktistakis Nicholas T. et al., In The Journal of Cell Biology, 2004
... Butcher, Babraham Institute, Cambridge, England, UK), rabbit anti-GFP (Invitrogen), 9E10 mouse anti-myc, rabbit anti–MAP-LC3 (Santa Cruz Biotechnology Inc.), rabbit anti–MAP-LC3 (Sigma-Aldrich), ...
The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases
Gottlieb Roberta A. et al., In Journal of Cardiovascular Translational Research, 2003
... Anesthetized mCherry-LC3 transgenic mice were subjected to ...
Comparison of the effect of mitochondrial inhibitors on mitochondrial membrane potential in two different cell lines using flow cytometry and spectrofluorometry
Manié S N et al., In Cell Death & Disease, 2002
... IA, USA), anti-cathepsin D (Ab-2, Calbiochem, Saint Quentin en Yvelines, France), anti-p62 (SQSTM1, Enzo, Villeurbane, France), anti-LC3 (51–11, MBL International Corporation, Nanterre, France), ...
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
Carpenter G H et al., In Cell Death & Disease, 2001
... (Hitchin, Hertfordshire, UK), anti-LC3 (2775S) (1:250 for western blotting) antibody was from New England Biolabs Inc., anti-AQP5 (sc-9891) antibody ...
Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors.
Seed Brian et al., In Genome Biology, 2001
... The Actin-LC3-dNGLUC construct was generated by PCR of hMAP1LC3 (Origene Trueclone AB2841G10) using primers ...
Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain
Golde Todd E et al., In Molecular Neurodegeneration, 2001
... No significant change in the autophagic marker (microtubule-associated protein light chain 3, LC3) was seen in mIL-4 expressing 5.5 month old transgenic CRND8 mice (TG, A) ...
p62 is a common component of cytoplasmic inclusions in protein aggregation diseases
Goedert Michel et al., In Brain, 2001
... Autophagy was assessed using an antibody against microtubule-associated protein light chain 3 (LC3) (Novus Biologicals).
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
Linden Rafael, In PLoS ONE, 2000
... and activator of transcription 1 (STAT1) and phospho-STAT1 (Tyr 701) from Cell Signaling (Beverly, MA), anti- LC3 from MBL (Nagoya, Japan), anti-mitochondrial preprotein ...
Antibody and/or cell-mediated immunity, protective mechanisms in fungal disease: an ongoing dilemma or an unnecessary dispute
Ross Susan, In PLoS Pathogens, 1997
... legs of 8 to 12-week old male wild-type C57BL/6J (The Jackson Laboratory, Bar Harbor, Maine) or GFP-LC3 transgenic mice [ ...
Neuronal ubiquitin and neurofilament expression in different lysosomal storage disorders
Elleder Milan et al., In Acta Neuropathologica, 1991
... LC3 (rabbit polyclonal) [27]MBL, Naka-ku Nagoya, Japan ...
New colorimetric cytotoxicity assay for anticancer-drug screening
Beguinot F et al., In Cell Death and Differentiation, 1989
... CA, USA); the FoxO1 and pFoxO1 antibodies were from Upstate Biotechnolgy (Lake Placid, NY, USA); LC3 antibodies were from Cell Signaling Technology, Inc ...
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