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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

LATS, large tumor suppressor, homolog 2

LATS2, KPM
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: YAP, miR, CAN, p53, TAZ
Papers on LATS2
Down-regulation of LATS kinases alters p53 to promote cell migration.
New
Oren et al., Israel. In Genes Dev, Dec 2015
We now report that silencing of the Hippo pathway tumor suppressors LATS1 and LATS2 in nontransformed mammary epithelial cells reduces p53 phosphorylation and increases its association with the p52 NF-κB subunit.
Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway.
New
Jiang et al., Wuhan, China. In Oncotarget, Nov 2015
Herein, we reported that miR-181c directly repressed MST1, LATS2, MOB1 and SAV1 expression in human pancreatic cancer cells.
Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase.
Impact
Wu et al., Tianjin, China. In Nat Cell Biol, 2015
We demonstrate that the E3 ubiquitin ligase SIAH2 stimulates YAP by destabilizing LATS2, a critical component of the Hippo pathway, in response to hypoxia.
Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B.
Nojima et al., Suita, Japan. In Sci Rep, 2014
Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and regulate development and tumorigenesis by coordinating the balance between cell proliferation and apoptosis.
A Cell Biologist's Field Guide to Aurora Kinase Inhibitors.
Shiau et al., Los Angeles, United States. In Front Oncol, 2014
In a cellular context, we demonstrate that immunofluorescence-based detection of LATS2 and histone H3 phospho-epitopes provides a facile and reliable means to assess potency and specificity of Aurora A versus Aurora B inhibition, and that G2 duration measured in a live imaging assay is a specific readout of Aurora A activity.
Genome-wide association study and biological pathway analysis of the Eimeria maxima response in broilers.
Bed'Hom et al., Paris, France. In Genet Sel Evol, 2014
Furthermore, the network-based analysis produced two networks of high confidence, with one centered on large tumor suppressor kinase 1 (LATS1) and 2 (LATS2) and the second involving the myosin heavy chain 6 (MYH6).
Role of microRNA-93 in regulation of angiogenesis.
Review
Liu et al., Tianjin, China. In Tumour Biol, 2014
MiRNA-93's effects on angiogenesis are dependent on the interaction of other multiple genes and signal pathways, such as P21, E2F1, integrin-β8, LATS2, etc. Future investigation should involve mapping the network by which miRNA-93 exerts its functions.
Hippo pathway key to ploidy checkpoint.
Impact
Guan et al., Hangzhou, China. In Cell, 2014
report that extra centrosome-induced activation of the Hippo pathway kinase LATS2 is a key mechanism of tetraploidy-induced cell-cycle arrest.
Cytokinesis failure triggers hippo tumor suppressor pathway activation.
Impact
Pellman et al., Boston, United States. In Cell, 2014
Induction of the Hippo pathway is triggered in part by extra centrosomes, which alter small G protein signaling and activate LATS2 kinase.
An emerging role for Hippo-YAP signaling in cardiovascular development.
Review
Zhou, Augusta, United States. In J Biomed Res, 2014
Recent studies demonstrate that cardiac-specific deletion of the Hippo pathway kinase Mst (STE20-like protein kinases) co-activator WW45 (WW domain-containing adaptor 45), Mst1, Mst2, or Lats2 (large tumor suppressor homologue 2) in mice result in over-grown hearts with elevated cardiomyocyte proliferation.
Function and cancer genomics of FAT family genes (review).
Review
Katoh, Tokyo, Japan. In Int J Oncol, 2012
Copy number aberration, translocation and point mutation of FAT1, FAT2, FAT3, FAT4, FRMD1, FRMD6, NF2, WWC1, WWC2, SAV1, STK3, STK4, MOB1A, MOB1B, LATS1, LATS2, YAP1 and WWTR1/TAZ genes should be comprehensively investigated in various types of human cancers to elucidate the mutation landscape of the FAT‑Hippo signaling cascades.
Protein kinases of the Hippo pathway: regulation and substrates.
Review
Barrufet et al., Boston, United States. In Semin Cell Dev Biol, 2012
In mammals, the Hippo orthologs Mst1 and Mst2 utilize the Salvador ortholog WW45/Sav1 and other scaffolds to regulate the kinases Lats1/Lats2 and ndr1/ndr2.
Transcriptional analysis of pluripotency reveals the Hippo pathway as a barrier to reprogramming.
GeneRIF
Ramalho-Santos et al., San Francisco, United States. In Hum Mol Genet, 2012
LATS2 represses reprogramming in cells by post-transcriptionally antagonizing TAZ but not YAP, two downstream effectors of the Hippo pathway.
Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.
GeneRIF
Longmore et al., Saint Louis, United States. In Embo J, 2012
Lats2 kinase as a novel regulator of Snail1 protein level, subcellular localization, and thus, activity
Deregulation of Hippo kinase signalling in human hepatic malignancies.
GeneRIF
Apte et al., Kansas City, United States. In Liver Int, 2012
Yap induction mediated by inactivation of Lats is observed in hepatic malignancies.
MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2.
GeneRIF
Zhang et al., Newark, United States. In J Biol Chem, 2012
MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog
Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.
GeneRIF
McCollum et al., Worcester, United States. In Mol Biol Cell, 2011
AMOTL2 is as a novel activator of LATS2.
p53: guardian of ploidy.
Review
Oren et al., Portugal. In Mol Oncol, 2011
The tumor suppressor Lats2, along with other tumor inhibitory proteins such as BRCA1/2 and BubR1, are central to p53-dependent elimination of tetraploid cells.
Mst out and HCC in.
Impact
Guan et al., San Diego, United States. In Cancer Cell, 2009
Unexpectedly, Mst1/2 may activate another kinase besides Lats1 and Lats2 to phosphorylate YAP, and the role of Mst1/2 in YAP regulation is cell type dependent.
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.
Impact
Agami et al., Amsterdam, Netherlands. In Cell, 2006
These miRNAs neutralize p53-mediated CDK inhibition, possibly through direct inhibition of the expression of the tumor-suppressor LATS2.
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