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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Linker for activation of T cells

The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, ZAP-70, SLP-76
Papers using LAT antibodies
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends.
Schweisguth Francois, In PLoS ONE, 2005
... Phospho-specific ZAP70 and LAT antibodies were purchased from Cell Signaling Tech and Biosource, respectively ...
Papers on LAT
High-resolution antibody array analysis of childhood acute leukemia cells.
Kalina et al., Praha, Czech Republic. In Mol Cell Proteomics, Feb 2016
From non-CD markers, we found DBN1, PAX5, or PTK2 overexpressed in B-cell precursor acute lymphoblastic leukemias, LAT, SH2D1A, or STAT5A overexpressed in T-cell acute lymphoblastic leukemias, and HCK, GLUD1, or SYK overexpressed in acute myeloid leukemias.
Heat shock protein 70 (Hsp70) regulates platelet integrin activation, granule secretion and aggregation.
Aslan et al., Oregon, United States. In Am J Physiol Cell Physiol, Feb 2016
Biochemical studies supported a role for Hsp70 in maintaining the assembly of the linker for activation of T cells (LAT) signalosome, which couples GPVI-initiated signaling to integrin activation, secretion and platelet function.
Effects of dietary DL-2-hydroxy-4(methylthio)butanoic acid supplementation on growth performance, indices of ascites syndrome, and antioxidant capacity of broilers reared at low ambient temperature.
Zeng et al., Chengdu, China. In Int J Biometeorol, Feb 2016
UNASSIGNED: This study examined the effects of dietary DL-2-hydroxy-4(methylthio)butanoic acid (DL-HMTBA) supplementation on growth performance, antioxidant capacity, and ascites syndrome (AS) in broilers reared at low ambient temperature (LAT) from 7 to 28 days of age.
Preferential Killing of HIV Latently Infected CD4+ T cells by MALT1 Inhibitor.
Wang et al., Qiqihar, China. In Aids Res Hum Retroviruses, Feb 2016
UNASSIGNED: We report that the addition of an host paracaspase MALT1 inhibitor, MI-2, to HIV latently infected ACH-2, Jurkat E4, and J-LAT cells accelerated cell death in the presence of cell stimuli or the PKC agonist, bryostatin 1. MI-2-mediated cell death correlated with the induction of the cellular RNase MCPIP1 and requires the presence of viral component(s).
Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters.
Gundacker et al., Vienna, Austria. In Toxicology, Jan 2016
RESULTS: We found the amino acid transporter subunits L-Type Amino Acid Transporter (LAT)1 and rBAT (related to b(0,+) type amino acid transporter) as well as the efflux transporter Multidrug Resistance Associated Protein (MRP)1 to be involved in mercury kinetics of trophoblast cells (t-Test P<0.05).
The Linker for Activation of T Cells (LAT) Signaling Hub: From Signaling Complexes to Microclusters.
Samelson et al., Bethesda, United States. In J Biol Chem, Nov 2015
Since the cloning of the critical adapter, LAT (linker for activation of T cells), more than 15 years ago, a combination of multiple scientific approaches and techniques continues to provide valuable insights into the formation, composition, regulation, dynamics, and function of LAT-based signaling complexes.
[Herpes simplex virus type 1 latency and reactivation: an update].
Epstein et al., Montigny-le-Bretonneux, France. In Med Sci (paris), May 2015
During latency, the virus genome remains as a chromatinized episome expressing only a set of latency-associated transcripts (LAT) and a group of microRNAs that inhibit expression of key lytic viral functions.
[Battle with herpes for 37 years].
Shimomura, In Nihon Ganka Gakkai Zasshi, Mar 2015
3) Only latency-associated transcript (LAT) detected and transcriptional products of other virus genes (α, β, γ) not detected in the cornea.
L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.
Holst et al., Australia. In Am J Cancer Res, 2014
We review the expression and function of the LAT family in cancer, as well as the recent development of specific inhibitors targeting LAT1 or LAT3.
Bacteria-induced intracellular signalling in platelets.
McNicol, In Platelets, 2014
This leads to and involves the tyrosine kinase Syk, the adaptor protein Linker of Activated T Cells (LAT) and subsequently both phospholipase Cγ2 (PLCγ2) and phosphatidylinositol-3-kinase (PI-3-K).
Integrative biology of T cell activation.
Roncagalli et al., Marseille, France. In Nat Immunol, 2014
We illustrate the utility of this integrative approach with the transmembrane signaling protein Lat, which is a key signaling hub of the TCR signal-transduction network, as a connecting thread.
Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub.
Malissen et al., Marseille, France. In Nat Immunol, 2014
Here we used quantitative mass spectrometry and activated primary CD4(+) T cells from mice in which a tag for affinity purification was knocked into several genes to determine the composition and dynamics of multiprotein complexes that formed around the kinase Zap70 and the adaptors Lat and SLP-76.
VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites.
Hivroz et al., Paris, France. In Nat Immunol, 2013
The mechanisms by which Lat (a key adaptor in the T cell antigen receptor (TCR) signaling pathway) and the TCR come together after TCR triggering are not well understood.
HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.
Fackler et al., Heidelberg, Germany. In J Immunol, 2012
Nef employs a dual mechanism to disturb early TCR signaling by limiting the communication between LAT and SLP-76
Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
Zhang et al., Durham, United States. In Mol Cell Biol, 2012
LAT-deficient CTLs failed to upregulate FasL and produce gamma interferon after engagement with target cells and had impaired granule-mediated killing.
The transmembrane adaptor protein, linker for activation of T cells (LAT), regulates RANKL-induced osteoclast differentiation.
Kim et al., Kwangju, South Korea. In Mol Cells, 2012
our data suggest that LAT acts as a positive regulator of RANKL-induced osteoclastogenesis.
Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.
Goldstein et al., United States. In Plos One, 2011
Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2
Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.
Samelson et al., Bethesda, United States. In Immunity, 2011
The kinase ZAP-70 distributed completely with the TCRζ chain and both partially mixed with the adaptor LAT in activated cells, thus showing localized activation of LAT by TCR-coupled ZAP-70.
A negatively charged domain of LAT mediates its interaction with the active form of Lck.
Jury et al., London, United Kingdom. In Mol Membr Biol, 2011
the segment comprising residues 112-126 of human LAT is required for its interaction with Lck.
New insights into the T cell synapse from single molecule techniques.
Depoil et al., New York City, United States. In Nat Rev Immunol, 2011
The process then requires the assembly of signalling complexes between the TCR and the adaptor protein linker for activation of T cells (LAT), and subsequent filamentous actin (F-actin)-dependent TCR cluster formation.
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