High-resolution antibody array analysis of childhood acute leukemia cells.
Praha, Czech Republic. In Mol Cell Proteomics, Feb 2016
From non-CD markers, we found DBN1, PAX5, or PTK2 overexpressed in B-cell precursor acute lymphoblastic leukemias, LAT, SH2D1A, or STAT5A overexpressed in T-cell acute lymphoblastic leukemias, and HCK, GLUD1, or SYK overexpressed in acute myeloid leukemias.
Preferential Killing of HIV Latently Infected CD4+ T cells by MALT1 Inhibitor.
Qiqihar, China. In Aids Res Hum Retroviruses, Feb 2016
UNASSIGNED: We report that the addition of an host paracaspase MALT1 inhibitor, MI-2, to HIV latently infected ACH-2, Jurkat E4, and J-LAT cells accelerated cell death in the presence of cell stimuli or the PKC agonist, bryostatin 1. MI-2-mediated cell death correlated with the induction of the cellular RNase MCPIP1 and requires the presence of viral component(s).
[Herpes simplex virus type 1 latency and reactivation: an update].
Montigny-le-Bretonneux, France. In Med Sci (paris), May 2015
During latency, the virus genome remains as a chromatinized episome expressing only a set of latency-associated transcripts (LAT) and a group of microRNAs that inhibit expression of key lytic viral functions.
[Battle with herpes for 37 years].
In Nihon Ganka Gakkai Zasshi, Mar 2015
3) Only latency-associated transcript (LAT) detected and transcriptional products of other virus genes (α, β, γ) not detected in the cornea.
Integrative biology of T cell activation.
Marseille, France. In Nat Immunol, 2014
We illustrate the utility of this integrative approach with the transmembrane signaling protein Lat, which is a key signaling hub of the TCR signal-transduction network, as a connecting thread.