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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

LIM and SH3 protein 1

Lasp-1, LIM and SH3 domain protein, LIM and SH3 protein, LIM and SH3 protein 1
This gene encodes a member of a LIM protein subfamily characterized by a LIM motif and a domain of Src homology region 3. The encoded protein functions as an actin-binding protein and possibly in cytoskeletal organization. [provided by RefSeq, Jan 2009] (from NCBI)
Top mentioned proteins: LIM, Actin, nebulin, CAN, miR
Papers on Lasp-1
The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells.
New
Kämmerer et al., Hamburg, Germany. In Arch Gynecol Obstet, Feb 2016
Overexpression of the cytoskeletal protein LASP-1 was shown to contribute to cancer aggressiveness.
Upregulated LASP-1 correlates with a malignant phenotype and its potential therapeutic role in human cholangiocarcinoma.
New
Gong et al., Shanghai, China. In Tumour Biol, Feb 2016
UNASSIGNED: LIM and SH3 protein 1 (LASP-1) is demonstrated to play a key role in occurrence and development of tumors.
LASP-1, regulated by miR-203, promotes tumor proliferation and aggressiveness in human non-small cell lung cancer.
New
Wang et al., Weifang, China. In Exp Mol Pathol, Jan 2016
UNASSIGNED: The LIM and SH3 protein 1 (LASP-1) has been reported to be associated with tumor development and progression.
The tumor-suppressive function of miR-1 by targeting LASP1 and TAGLN2 in esophageal squamous cell carcinoma.
New
Liu et al., Shijiazhuang, China. In J Gastroenterol Hepatol, Oct 2015
OBJECTIVE: This study determined the expression of microRNA-1 in esophageal squamous cell carcinoma (ESCC) tissue and cell lines to evaluate its effects on clinicopathological parameters and its target gene LASP1, TAGLN2.
Differences in the resting platelet proteome and platelet releasate between healthy children and adults.
New
Ignjatovic et al., Australia. In J Proteomics, Jul 2015
Serotransferrin, fibrinogen alpha chain, glyceraldehyde-3 phosphate dehydrogenase, serum albumin, transgelin-2, calponin-2/LIM and SH3 domain protein 1 and human chorionic gonadotropin 2039797 were up-regulated, whereas thrombospondin-1 was down-regulated in children.
LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex.
New
Raman et al., Nashville, United States. In Oncogene, Jun 2015
UNASSIGNED: Nuclear LASP-1 (LIM and SH3 protein-1) has a direct correlation with overall survival of breast cancer patients.
Molecular characterization of LASP-1 expression reveals vimentin as its new partner in human hepatocellular carcinoma cells.
New
De Petro et al., Brescia, Italy. In Int J Oncol, May 2015
Our results suggest that LASP-1 mRNA overexpression may be mainly implicated in female HCCs and cirrhotic HCCs; and that LASP1 may play its role with vimentin in HCC cells.
Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors.
New
Sohn et al., Seoul, South Korea. In Oncotarget, Apr 2015
Transcriptome sequencing revealed 328 gene fusions, and the most frequently involved fusion events were associated with IGF2 fused to several partner genes including CCND1, FUS, and LASP1.
LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer.
Hao et al., Tianjin, China. In Cancer Res, 2015
LASP1 is an actin-binding protein associated with actin assembly dynamics in cancer cells.
An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein.
Review
Grunewald et al., Würzburg, Germany. In Oncotarget, 2015
The gene encoding the LIM and SH3 domain protein (LASP1) was cloned two decades ago from a cDNA library of breast cancer metastases.
LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression.
Butt et al., Würzburg, Germany. In Plos One, 2014
The LIM and SH3 protein 1 (LASP1) is a focal adhesion protein.
Roles of Nebulin Family Members in the Heart.
Review
Chen et al., Milano, Italy. In Circ J, 2014
The members of the nebulin protein family, including nebulin, nebulette, LASP-1, LASP-2, and N-RAP, contain various numbers of nebulin repeats and bind to actin, but are otherwise heterogeneous with regard to size, expression pattern, and function.
Profilin-1 overexpression in MDA-MB-231 breast cancer cells is associated with alterations in proteomics biomarkers of cell proliferation, survival, and motility as revealed by global proteomics analyses.
Moens et al., Armidale, Australia. In Omics, 2014
Using MDA-MB-231 as a model breast cancer cell line, we provide evidence that PFN1 overexpression is associated with alterations in the expression of proteins that have been functionally linked to cell proliferation (FKPB1A, HDGF, MIF, PRDX1, TXNRD1, LGALS1, STMN1, LASP1, S100A11, S100A6), survival (HSPE1, HSPB1, HSPD1, HSPA5 and PPIA, YWHAZ, CFL1, NME1) and motility (CFL1, CORO1B, PFN2, PLS3, FLNA, FLNB, NME2, ARHGDIB).
Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis.
Watt et al., Cambridge, United Kingdom. In Cell Rep, 2014
In vivo genetic reconstitution experiments show that miR-203 inhibits lung metastasis by suppressing the prometastatic activities of three factors involved in cytoskeletal dynamics (LASP1), extracellular matrix remodeling (SPARC), and cell metabolism (NUAK1).
Lasp-1 regulates podosome function.
GeneRIF
Kremerskothen et al., Münster, Germany. In Plos One, 2011
Data indicate that Lasp-1 is a novel component of podosomes and is involved in the regulation of podosomal function.
The Nebulin family: an actin support group.
Review
Gregorio et al., Tucson, United States. In Trends Cell Biol, 2011
Nebulin, a giant, actin-binding protein, is the largest member of a family of proteins (including N-RAP, nebulette, lasp-1 and lasp-2) that are assembled in a variety of cytoskeletal structures, and expressed in different tissues.
[Impact of LASP-1 expression on proliferation and tumorigenesis of human colorectal cancer cell line SW480].
GeneRIF
Ding et al., Guangzhou, China. In Zhonghua Bing Li Xue Za Zhi, 2010
LASP-1 gene expression enhances proliferation of colorectal cancer cells and may serve as a useful marker for colorectal cancer progression.
Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma.
GeneRIF
Pfister et al., Würzburg, Germany. In Cancer Res, 2010
LASP1 knockdown by small interfering RNA-mediated silencing indicates its funcion role in progression and metastasis of medulloblastoma.
Comparative proteomic analysis identifies proteins associated with the development and progression of colorectal carcinoma.
GeneRIF
Ding et al., Guangzhou, China. In Febs J, 2010
LASP-1, S100A9 and RhoGDI were detected by proteomic analysis to be differentially expressed between normal mucosa, non-metastatic colorectal carcinoma and metastatic CRC tissue
Promotion of colorectal cancer growth and metastasis by the LIM and SH3 domain protein 1.
GeneRIF
Ding et al., Guangzhou, China. In Gut, 2010
Overexpression of LASP-1 was found in metastatic colorectal cancer (CRC) tissues (p=0.002), and its expression level was closely correlated with overall survival of patients with CRC (p=0.002).
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