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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cancer susceptibility candidate 1

lasI, Las1, Casc1, CASCI, lung adenoma susceptibility 1
Top mentioned proteins: CAN, elastase, ACID, V1a, HAD
Papers on lasI
Mechanism for the Enhanced Excited-State Lewis Acidity of Methyl Viologen.
New
Hohenstein, New York City, United States. In J Am Chem Soc, Feb 2016
Using a complete active space configuration interaction (CASCI) approach, excited-state molecular dynamics simulations of aqueous MV(2+) are performed in order to test the hypothesis that MV(2+) acts as a Lewis photoacid and to elucidate a mechanism for this behavior.
Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities.
New
Hurt et al., Heidelberg, Germany. In Mol Cell, Jan 2016
Here we describe the existence of an RNA processome, assembled from four conserved subunits, Las1-Grc3-Rat1-Rai1, that carries all the necessary RNA processing enzymes to mediate coordinated ITS2 rRNA removal.
The quorum-sensing inhibiting effects of stilbenoids and their potential structure-activity relationship.
New
Jia et al., Nanjing, China. In Bioorg Med Chem Lett, Dec 2015
Further transcriptome analyses showed that 1-3 suppressed the expression of QS-induced genes: lasR, lasI, rhlR and rhlI.
Promotion of acute-phase skin wound healing by Pseudomonas aeruginosa C4 -HSL.
New
Tachi et al., Sendai, Japan. In Int Wound J, Nov 2015
In our previous study, 3-oxo-C12 -HSL, encoded by lasI gene, was shown to promote wound healing.
Nanoscale Multireference Quantum Chemistry: Full Configuration Interaction on Graphical Processing Units.
New
Levine et al., East Lansing, United States. In J Chem Theory Comput, Nov 2015
When applied to a 1.7 × 1.4 × 1.4 nm silicon nanoparticle (Si72H64) described with the polarized, all-electron 6-31G** basis set, our implementation can solve for the ground state of the 16-active-electron/16-active-orbital CASCI Hamiltonian (more than 100,000,000 configurations) in 39 min on a single NVidia K40 GPU.
Multireference Second Order Perturbation Theory with a Simplified Treatment of Dynamical Correlation.
New
Li et al., Nanjing, China. In J Chem Theory Comput, Nov 2015
A multireference second order perturbation theory based on a complete active space configuration interaction (CASCI) function or density matrix renormalized group (DMRG) function has been proposed.
Cooperative pathogenicity in cystic fibrosis: Stenotrophomonas maltophilia modulates Pseudomonas aeruginosa virulence in mixed biofilm.
Di Bonaventura et al., Chieti, Italy. In Front Microbiol, 2014
When grown in mixed biofilm with S. maltophilia, P. aeruginosa significantly over-expressed aprA, and algD-codifying for protease and alginate, respectively-while the quorum sensing related rhlR and lasI genes were down-regulated.
Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase.
Steinberg et al., Jerusalem, Israel. In Sci Rep, 2014
LasI is an acyl-homoserine lactone synthase that produces a quorum-sensing (QS) signal that positively regulates numerous P. aeruginosa virulence determinants.
Correlation of quorum sensing and virulence factors in Pseudomonas aeruginosa isolates in Egypt.
Baraka et al., Alexandria, Egypt. In J Infect Dev Ctries, 2014
The four genes lasR, lasI, rhlR,and rhlI were found to regulate this QS system.
Toward Reliable Prediction of Hyperfine Coupling Constants Using Ab Initio Density Matrix Renormalization Group Method: Diatomic (2)Σ and Vinyl Radicals as Test Cases.
Yanai et al., Okazaki, Japan. In J Chem Theory Comput, 2014
The density matrix renormalization group (DMRG) method is used in conjunction with the complete active space (CAS) procedure, the CAS configuration interaction (CASCI), and the CAS self-consistent field (CASSCF) to evaluate hyperfine coupling constants (HFCCs) for a series of diatomic (2)Σ radicals (BO, CO(+), CN, and AlO) and vinyl (C2H3) radical.
An evolving perspective on the Pseudomonas aeruginosa orphan quorum sensing regulator QscR.
Review
Greenberg et al., Seattle, United States. In Front Cell Infect Microbiol, 2013
P. aeruginosa encodes two AHL synthases and three AHL responsive receptors, LasI-LasR form a cognate synthase-receptor pair as do RhlI-RhlR.
Degradation of lung adenoma susceptibility 1, a major candidate mouse lung tumor modifier, is required for cell cycle progression.
GeneRIF
You et al., Saint Louis, United States. In Cancer Res, 2007
The differential degradation of Las1-A/J and Las-B6 produced from the 2 corresponding alleles, has important implications for its intracellular function and may eventually explain Las1-A/J in lung tumorigenesis.
CASCI Reference Wave Functions for Multireference Perturbation Theory Built from Hartree-Fock or Kohn-Sham Orbitals.
McDouall et al., Manchester, United Kingdom. In J Chem Theory Comput, 2007
The MRMP2 method and many similar variants of multireference perturbation theory have a potentially wide range of applicability.
Candidate lung tumor susceptibility genes identified through whole-genome association analyses in inbred mice.
Impact
GeneRIF
You et al., Saint Louis, United States. In Nat Genet, 2006
Whole-genome association analyis of lung tumor susceptibility refined the Pas1 locus to a region of less than 0.5 Mb containing two strong candidates, Kras2 and Casc1 (also known as Las1).
[Quorum sensing: a new clinical target for Pseudomonas aeruginosa?].
Review
Guery et al., Lille, France. In Med Mal Infect, 2006
The las system associates the transcriptionnal activator protein LasR and LasI responsible for the synthesis of a specific AHL: C12-HSL.
Lanosterol synthase in dicotyledonous plants.
GeneRIF
Ebizuka et al., Yokohama, Japan. In Plant Cell Physiol, 2006
The Arabidopsis gene At3g45130, designated LAS1, encodes a functional lanosterol synthase in plants.
Airway biofilms: implications for pathogenesis and therapy of respiratory tract infections.
Review
Kobayashi, Kami-renjaku, Japan. In Treat Respir Med, 2004
The 14- or 15-ring membered macrolides inhibit: (i) the alginate production from P. aeruginosa; (ii) the antibody reaction to alginate, which leads to a decrease in the immune complex formation; and (iii) the activation of the autoinducer 3-O-C12-homoserine lactone and subsequent expression of lasI and rhlI in quorum sensing systems in P. aeruginosa.
Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
GeneRIF
Dragani et al., Milano, Italy. In Oncogene, 2004
Las1 is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms and AA changes in lung tumor susceptibility. It may be a tumor suppressor.
Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice.
GeneRIF
You et al., Saint Louis, United States. In Proc Natl Acad Sci U S A, 2003
Identification of mouse Casc1 (Las1) as a candidate for lung cancer susceptibility, and comparison of the protein to the rat and human orthologs.
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