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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Lysosomal protein transmembrane 4 beta

LAPTM4B, Lysosomal protein transmembrane 4 beta
Top mentioned proteins: HAD, AGE, POLYMERASE, CAN, RANK
Papers on LAPTM4B
Predictive significance of combined LAPTM4B and VEGF expression in patients with cervical cancer.
New
Lou et al., Harbin, China. In Tumour Biol, Dec 2015
UNASSIGNED: Lysosome-associated protein transmembrane 4ß-35 (LAPTM4B-35) is overexpressed in several solid malignancies.
LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.
New
Ikonen et al., Helsinki, Finland. In Nat Chem Biol, Oct 2015
Lysosome-associated protein transmembrane-4b (LAPTM4B) associates with poor prognosis in several cancers, but its physiological function is not well understood.
Lysosome-associated protein transmembrane-4β-35 is a novel independent prognostic factor in small cell lung cancer.
New
Hu et al., Tianjin, China. In Tumour Biol, Sep 2015
The lysosome-associated protein transmembrane-4β-35 (LAPTM4B-35) protein has been indicated to be involved in solid tumors, while its role in small cell lung cancer (SCLC) remains unknown.
Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells.
New
Lucas et al., Brussels, Belgium. In J Biol Chem, Sep 2015
We identified lysosomal-associated transmembrane protein 4B (LAPTM4B), which interacts with GARP in mammalian cells and is expressed at higher levels in Tregs than in Th cells.
Lentivirus-mediated RNA Interference Targeting LAPTM4B Inhibits Human Ovarian Cancer Cell Invasion In Vitro.
New
Fu et al., Harbin, China. In Chem Biol Drug Des, Sep 2015
UNASSIGNED: LAPTM4B (lysosome-associated protein transmembrane 4 beta) play an important role in several human carcinomas.
[Impact of lysosome-associated protein transmembrane-4 beta on proliferation and invasion of colorectal cancer].
New
Zhong et al., Shanghai, China. In Zhonghua Wei Chang Wai Ke Za Zhi, Jun 2015
OBJECTIVE: To determine whether lysosome-associated protein transmembrane-4 beta (LAPTM4B) over-expression is associated with the proliferation and invasion in colorectal cancer (CRC).
A kinase-independent role for EGF receptor in autophagy initiation.
New
Impact
Anderson et al., Madison, United States. In Cell, Feb 2015
Inactive EGFR interacts with the oncoprotein LAPTM4B that is required for the endosomal accumulation of EGFR upon serum starvation.
Differential expression of lysosome-associated protein transmembrane-4 beta (LAPTM4B) in granulosa cells of ovarian follicles and in other bovine tissues.
Lussier et al., Saint-Hyacinthe, Canada. In J Ovarian Res, 2014
BACKGROUND: LAPTM4B is a member of the lysosome-associated transmembrane protein superfamily that is differentially expressed in normal human tissues and upregulated in various types of carcinomas.
LAPTM4B-35, a cancer-related gene, is associated with poor prognosis in TNM stages I-III gastric cancer patients.
Ji et al., Beijing, China. In Plos One, 2014
BACKGROUND: Lysosome-associated transmembrane protein 4β-35 (LAPTM4B-35), a member of the mammalian 4-tetratransmembrane spanning protein superfamily, has been reported to be overexpressed in several cancers.
LAPTM4B is associated with poor prognosis in NSCLC and promotes the NRF2-mediated stress response pathway in lung cancer cells.
Kadara et al., Houston, United States. In Sci Rep, 2014
We recently demonstrated that lysosomal protein transmembrane 4 beta (LAPTM4B) is elevated in non-small cell lung cancers (NSCLCs) and in the surrounding premalignant airway field of cancerization.
LAPTM4B down regulation inhibits the proliferation, invasion and angiogenesis of HeLa cells in vitro.
Lou et al., Harbin, China. In Cell Physiol Biochem, 2014
BACKGROUND/AIMS: LAPTM4B (lysosome-associated protein transmembrane 4 beta) is a novel oncogene with important functions in aggressive human carcinomas, including cervical cancer.
Lysosome and Cytoskeleton Pathways Are Robustly Enriched in the Blood of Septic Patients: A Meta-Analysis of Transcriptomic Data.
Review
Gao et al., Baltimore, United States. In Mediators Inflamm, 2014
The key regulatory genes in the "Lysosome" pathway include lysosomal acid hydrolases (e.g., protease cathepsin A, D) as well as the major (LAMP1, 2) and minor (SORT1, LAPTM4B) membrane proteins.
LAPTM4b recruits the LAT1-4F2hc Leu transporter to lysosomes and promotes mTORC1 activation.
Rotin et al., Toronto, Canada. In Nat Commun, 2014
Here we identified the lysosomal protein LAPTM4b as a binding partner for the Leu transporter, LAT1-4F2hc (SLC7A5-SLAC3A2).
The relationship between LAPTM4B polymorphisms and cancer risk in Chinese Han population: a meta-analysis.
Zhou et al., Shenyang, China. In Springerplus, 2014
LAPTM4B is a newly cloned gene that shows an active role in many solid tumors progression in substantial researches, mainly through the autophage function.
Association of LAPTM4B gene polymorphism with breast cancer susceptibility.
GeneRIF
Zhang et al., Beijing, China. In Cancer Epidemiol, 2012
LAPTM4B allelic variation was significantly associated with breast cancer occurrence, with adjusted odds ratios of 1.387 (95%CI = 1.111-1.730) for LAPTM4B*1/2 and 1.592 (95% CI = 1.043-2.430) for LAPTM4B*2/2 genotype.
Relationship between LAPTM4B gene polymorphism and susceptibility of primary liver cancer.
GeneRIF
Zhou et al., Beijing, China. In Ann Oncol, 2012
gene polymorphism of LAPTM4B may influence the individuals' susceptibility to primary liver cancer.
LAPTM4B polymorphisms is associated with ovarian cancer susceptibility and its prognosis.
GeneRIF
Lou et al., Harbin, China. In Jpn J Clin Oncol, 2012
Findings indicate that the LAPTM4B 2 allele may be a risk factor for ovarian cancer and may play an important role in genetic susceptibility to ovarian cancer.
LAPTM4B overexpression is a novel independent prognostic marker for metastatic ovarian tumors.
GeneRIF
Lou et al., Harbin, China. In Int J Gynecol Cancer, 2012
LAPTM4B expression was found to have a significant inverse correlation on prognosis in patients with metastatic ovarian tumors and may be an independent prognostic marker for metastatic ovarian tumors.
LAPTM4B allele *2 is a marker of poor prognosis following hepatic tumor resection for hepatocellular carcinoma.
GeneRIF
McNutt et al., Beijing, China. In Plos One, 2011
LAPTM4B is a risk factor associated with poor prognosis in patients with resected HCC. LAPTM4B status may be useful preoperatively as an adjunct in evaluation of the operability of HCC.
Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer.
Impact
Wang et al., Boston, United States. In Nat Med, 2010
SiRNA-mediated knockdown of either of two of these genes, the antiapoptotic gene YWHAZ and a lysosomal gene LAPTM4B, sensitized tumor cells to anthracyclines, and overexpression of either of the genes induced anthracycline resistance.
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