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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Leucine rich repeat containing 1

Lano, Leucine-rich repeat-containing, LRRC1, leucine-rich repeat-containing 1
Top mentioned proteins: Lgr5, V1a, HAIR, LGR4, CAN
Papers on Lano
Homeostatic responses of colonic LGR5+ stem cells following acute in vivo exposure to a genotoxic carcinogen.
New
Chapkin et al., College Station, United States. In Carcinogenesis, Jan 2016
Although the transformation of Leucine-rich repeat-containing G protein-coupled Receptor 5 (Lgr5)(+) cells is an extremely efficient route towards initiating small intestinal adenomas, the role of Lgr5(+) cells in CRC pathogenesis has not been well investigated.
A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors.
New
Passier et al., Leiden, Netherlands. In Sci Rep, Dec 2015
Finally, we identified cell surface markers for cardiac progenitors, such as the Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4), belonging to the same subfamily of LGR5, and LGR6, established tissue/cancer stem cells markers.
Intensive Immunofluorescence Staining Methods for Low Expression Protein: Detection of Intestinal Stem Cell Marker LGR5.
New
Suzuki et al., Gotemba, Japan. In Acta Histochem Cytochem, Nov 2015
Leucine-rich repeat-containing G-protein coupled receptor 5, or LGR5, is a molecule that recognizes stem cells in multiple organs and also in colon cancer.
LGR5 is associated with tumor aggressiveness in papillary thyroid cancer.
New
Henderson et al., Durham, United States. In Oncotarget, Nov 2015
PURPOSE: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a cancer stem cell marker and a down-stream target in Wnt/β-catenin signaling.
Lgr4 controls specialization of female gonads in mice.
New
Nishimori et al., Japan. In Biol Reprod, Oct 2015
Leucine-rich repeat-containing G protein-coupled receptor 4 (Lgr4) is a type of membrane receptor with a seven-transmembrane structure.
The prognostic role of Leucine-rich repeat-containing G-protein-coupled receptor 5 in gastric cancer: A systematic review with meta-analysis.
New
Bai et al., Zhengzhou, China. In Clin Res Hepatol Gastroenterol, Oct 2015
BACKGROUND AND OBJECTIVE: The prognostic value of Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) in gastric cancer remains controversial.
LGR5 promotes the proliferation of colorectal cancer cells via the Wnt/β-catenin signaling pathway.
New
Li et al., Shanghai, China. In Oncol Lett, Jun 2015
UNASSIGNED: Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) is an established cancer stem cell marker and is a target gene of the Wnt/β-catenin signaling pathway, a critical pathway in the process of tumor initiation and growth.
LGR4 and Its Role in Intestinal Protection and Energy Metabolism.
Review
Mulholland et al., Ann Arbor, United States. In Front Endocrinol (lausanne), 2014
Leucine-rich repeat-containing G protein-coupled receptors were identified by the unique nature of their long leucine-rich repeat extracellular domains.
Characterization of stem/progenitor cell cycle using murine circumvallate papilla taste bud organoid.
Montrose et al., Tokyo, Japan. In Sci Rep, 2014
Leucine-rich repeat-containing G-protein coupled receptor 5-expressing (Lgr5(+)) cells have been identified as stem/progenitor cells in the circumvallate papillae, and single cultured Lgr5(+) cells give rise to taste cells.
Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing.
Gontijo et al., Lisbon, Portugal. In Nat Commun, 2014
Here we mutate an invertebrate orphan relaxin receptor gene, the Drosophila Leucine-rich repeat-containing G protein-coupled receptor 3 (Lgr3), and find body asymmetries similar to those found in insulin-like peptide 8 (dilp8) mutants, which fail to coordinate growth with developmental timing.
Colon carcinogenesis: influence of Western diet-induced obesity and targeting stem cells using dietary bioactive compounds.
Review
Vanamala et al., Fort Collins, United States. In Nutrition, 2014
Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5), a Wnt target gene, and aldehyde dehydrogenase 1 B1 (ALDH1B1) are good markers for normal and malignant human colon stem cells.
Structure and function of LGR5: an enigmatic G-protein coupled receptor marking stem cells.
Review
Gulbis et al., Australia. In Protein Sci, 2014
Leucine-rich repeat-containing GPCRs contain a characteristic extracellular domain that is an important modulator of intracellular signaling.
Prognostic value of LGR5 in colorectal cancer: a meta-analysis.
Review
Zheng et al., Xi'an, China. In Plos One, 2013
OBJECTIVE: Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) has recently been reported to be a marker of cancer stem cells (CSCs) in colorectal cancer (CRC), and the prognostic value of LGR5 in CRC has been evaluated in several studies.
Leucine-rich repeat-containing G-protein-coupled receptors as markers of adult stem cells.
Review
Clevers et al., Utrecht, Netherlands. In Gastroenterology, 2010
Colon cancer research has led to the identification of 2 related receptors, leucine-rich repeat-containing, G-protein-coupled receptors (Lgr)5 and Lgr6, that are expressed by small populations of cells in a variety of adult organs.
Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites.
Impact
Christophides et al., London, United Kingdom. In Science, 2009
Leucine-rich repeat-containing proteins are central to host defense in plants and animals.
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