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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CD207 molecule, langerin

Langerin, CD207
The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: CD1, CAN, CD11c, CD8, DC-SIGN
Papers using Langerin antibodies
Follicular dendritic cell sarcoma in the lymph nodes of the neck
Supplier
Adam Patrick et al., In Diagnostic Pathology, 2006
... LangerineBioscience ...
Papers on Langerin
Paracoccidioides brasiliensis interacts with dermal dendritic cells and keratinocytes in human skin and oral mucosa lesions.
New
Sotto et al., São Paulo, Brazil. In Med Mycol, Feb 2016
The biopsies were subjected to immunohistochemical and/or immunofluorescence staining with anti-factor XIIIa (marker of dermal dendrocytes), anti-CD207 (marker of mature Langerhans cells), anti-pan cytokeratins (AE1-AE3) and anti-P.
Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation.
New
Impact
Xiong et al., United States. In Nat Immunol, Jan 2016
CD207(+) dendritic cells expressing the transcription factor Foxn1 were required for the proper generation of CCR10(+) ILCs.
Intradermal injection of an anti-Langerin-HIVGag fusion vaccine targets epidermal Langerhans cells in non-human primates and can be tracked in vivo.
New
Chapon et al., Paris, France. In Eur J Immunol, Jan 2016
Here, we specifically targeted vaccine antigens to epidermal Langerhans cells (LCs) using a fusion protein composed of HIV antigens and a monoclonal antibody targeting Langerin.
Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients.
New
Quaresma et al., Belém, Brazil. In Microb Pathog, Dec 2015
To analyze the presence of epidermal dendritic cells (CD1a and CD207), plasmacytoid dendritic cells (CD123) and dermal dendrocytes (factor XIIIa) in lesion fragments of leprosy patients, skin samples from 30 patients were studied.
The respiratory DC/macrophage network at steady-state and upon influenza infection in the swine biomedical model.
New
Bertho et al., Jouy-le-Moutier, France. In Mucosal Immunol, Dec 2015
Pig cDC2 shared some characteristics observed in human but not in mice, such as the expression of FCɛRIα and Langerin, and an intra-epithelial localization.
Cell(s) of Origin of Langerhans Cell Histiocytosis.
Review
New
Allen et al., Houston, United States. In Hematol Oncol Clin North Am, Oct 2015
Langerhans cell histiocytosis (LCH) is heterogeneous disease characterized by common histology of inflammatory lesions containing Langerin(+) (CD207) histiocytes.
The role of human dendritic cells in HIV-1 infection.
Review
New
Piguet et al., Cardiff, United Kingdom. In J Invest Dermatol, May 2015
DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively.
Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X?
Review
New
Allen et al., New York City, United States. In Br J Haematol, Apr 2015
Langerhans cell histiocytosis (LCH), the most common histiocytic disorder, is characterized by the accumulation of CD1A(+) /CD207(+) mononuclear phagocytes within granulomatous lesions that can affect nearly all organ systems.
Chinese Erdheim-Chester disease: clinical-pathology-PET/CT updates.
Liao et al., Guangzhou, China. In Endocrinol Diabetes Metab Case Rep, 2014
Immunohistochemistry stain was positive for CD68, negative for CD207/Langerin and S-100.
Pulmonary Langerhans cell histiocytosis with cervical lymph node involvement, and coexistence with pulmonary tuberculosis and right pneumothorax: a case report and review of literature.
Review
Zhang et al., Chengdu, China. In Int J Clin Exp Pathol, 2014
Immunohistochemically, the histiocytoid cells were positive for Langerin, CD1a and S-100.
Functional Specialization of Skin Dendritic Cell Subsets in Regulating T Cell Responses.
Review
Stoitzner et al., Mainz, Germany. In Front Immunol, 2014
The generation of in vivo cell ablation and lineage tracing models revealed the complexity of the skin DC network and, in particular, established the existence of a number of phenotypically distinct Langerin(+) and negative DC populations in the dermis.
Skin langerin+ dendritic cells transport intradermally injected anti-DEC-205 antibodies but are not essential for subsequent cytotoxic CD8+ T cell responses.
GeneRIF
Romani et al., Innsbruck, Austria. In J Immunol, 2012
Langerin-positive dendritic cells appear to be the predominant, though not exclusive, population responsible for in vivo transport of anti-DEC-205 antibodies from the skin to the draining lymph nodes in steady state and inflammation.
Conditional deletion of TGF-βR1 using Langerin-Cre mice results in Langerhans cell deficiency and reduced contact hypersensitivity.
GeneRIF
Clausen et al., Rotterdam, Netherlands. In J Immunol, 2011
A langerin-cre recombinase transgenic knockin mouse strain is generated that efficiently targets Langerhans cells and other langerin-positive dendritic cells, in particular, in the dermis and the lung.
Comparative analysis reveals selective recognition of glycans by the dendritic cell receptors DC-SIGN and Langerin.
GeneRIF
Skerra et al., Freising, Germany. In Protein Eng Des Sel, 2011
This study involves a comprehensive comparison of the glycan specificities of both the carbohydrate-recognition domains (CRDs) of DC-SIGN and Langerin.
Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4⁺ T cells but are incapable of cross-presentation.
GeneRIF
Geijtenbeek et al., Amsterdam, Netherlands. In Eur J Immunol, 2011
measles virus receptor on Langergans cells
Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses.
Impact
Kaplan et al., Minneapolis, United States. In Immunity, 2011
There are at least three subsets of skin DC- Langerhans cells (LC), Langerin(+) dermal DCs (dDCs), and classic dDCs.
The earliest intrathymic precursors of CD8α(+) thymic dendritic cells correspond to myeloid-type double-negative 1c cells.
GeneRIF
Malissen et al., Marseille, France. In Eur J Immunol, 2011
Data demonstrated that CD207(+) CD8alpha(+) thymic DCs do not share a common origin with T cells but originate from intrathymic precursors.
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cells.
Review
Impact
Collin et al., New York City, United States. In Nat Rev Immunol, 2008
Langerin is a lectin that serves as a valuable marker for LCs in mice and humans.
Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells.
Impact
Ueno et al., Dallas, United States. In Immunity, 2008
Little is known about the functional differences between the human skin myeloid dendritic cell (DC) subsets, epidermal CD207(+) Langerhans cells (LCs) and dermal CD14(+) DCs.
Langerin is a natural barrier to HIV-1 transmission by Langerhans cells.
Impact
GeneRIF
Geijtenbeek et al., Amsterdam, Netherlands. In Nat Med, 2007
Langerin prevents HIV-1 transmission by Langernhans cells.
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