High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells.
Taiwan. In Sci Rep, Dec 2015
The top five upregulated genes were SNAI2, FGFBP1, VIM, SPARC (osteonectin), and SERPINE1, while the downregulated genes included OCLN, TJP1 (ZO-1), FZD7, CDH1 (E-cadherin), and LAMA5.
DNA hypermethylation of extracellular matrix-related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis.
Tōbetsu, Japan. In J Periodontal Res, Dec 2015
Among these genes, hypermethylation of nine ECM-related genes, FANK1, COL4A1-A2, 12A1 and 15A1, LAMA5 and B1, MMP25, POMT1 and EMILIN3, induced a significantly downregulated expression of their mRNA.
Laminin-332 and -511 in skin.
Ōsaka, Japan. In Exp Dermatol, 2008
Keratinocytes of the skin secrete numerous laminin isoforms, including laminin-511 and laminin-332.
Laminin isoforms and lung development: all isoforms are not equal.
Saint Louis, United States. In Dev Biol, 2006
In vivo studies of laminin alpha5-deficient mice indicate that this laminin chain, found in laminins 511 and 521, is essential for normal lobar septation in early lung development and normal alveolization and distal epithelial cell differentiation and maturation in late lung development.