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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Laminin, alpha 5

laminin alpha5, Lama5, laminin-511
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SLAM, Alpha-1, CAN, V1a, CD45
Papers on laminin alpha5
High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells.
Lee et al., Taiwan. In Sci Rep, Dec 2015
The top five upregulated genes were SNAI2, FGFBP1, VIM, SPARC (osteonectin), and SERPINE1, while the downregulated genes included OCLN, TJP1 (ZO-1), FZD7, CDH1 (E-cadherin), and LAMA5.
DNA hypermethylation of extracellular matrix-related genes in human periodontal fibroblasts induced by stimulation for a prolonged period with lipopolysaccharide derived from Porphyromonas gingivalis.
Abiko et al., Tōbetsu, Japan. In J Periodontal Res, Dec 2015
Among these genes, hypermethylation of nine ECM-related genes, FANK1, COL4A1-A2, 12A1 and 15A1, LAMA5 and B1, MMP25, POMT1 and EMILIN3, induced a significantly downregulated expression of their mRNA.
α-5 Laminin Synthesized by Human Pluripotent Stem Cells Promotes Self-Renewal.
Masters et al., Madison, United States. In Stem Cell Reports, Sep 2015
Inducible shRNA knockdown and Cas9-mediated disruption of the LAMA5 gene dramatically reduced hPSC self-renewal and increased apoptosis without affecting the expression of pluripotency markers.
[DNA methylation in the promoter regions of the laminin family genes in normal and breast carcinoma tissues].
Strelnikov et al., Moscow, Russia. In Mol Biol (mosk), Jul 2015
Genes that are rarely if ever methylated in breast carcinoma include LAMA5 and LAMC1.
Laminin-511 and -521 enable efficient in vitro expansion of human corneal endothelial cells.
Koizumi et al., Kyoto, Japan. In Invest Ophthalmol Vis Sci, May 2015
The effect of laminin-511 and -521 on cell adhesion and proliferation was evaluated.
Changes in Laminin Expression Pattern during Early Differentiation of Human Embryonic Stem Cells.
Jaks et al., Tartu, Estonia. In Plos One, 2014
Laminin isoforms laminin-511 and -521 are expressed by human embryonic stem cells (hESC) and can be used as a growth matrix to culture these cells under pluripotent conditions.
Signaling involved in hair follicle morphogenesis and development.
Mokry et al., Hradec Králové, Czech Republic. In Int J Mol Sci, 2013
Primary cilia formation is initiated with epithelial laminin-511 interaction with dermal β-1 integrin, which also upregulates expression of downstream effectors of Shh pathway in dermal lineage.
Laminin-511: a multi-functional adhesion protein regulating cell migration, tumor invasion and metastasis.
Kusuma et al., Melbourne, Australia. In Cell Adh Migr, 2013
The laminin-511 heterotrimer (α5β1γ1) is one of the more recent isoforms to be identified and a potent adhesive and pro-migratory substrate for a variety of normal and tumor cell lines in vitro.
α1- and α5-containing laminins regulate the development of bile ducts via β1 integrin signals.
Miyajima et al., Sapporo, Japan. In J Biol Chem, 2012
alpha1- and alpha5-containing laminins differentially regulate the sequential events to form epithelial tissues via beta1 integrin signals.
Identification of active sequences in the L4a domain of laminin α5 promoting neurite elongation.
Kikkawa et al., Tokyo, Japan. In Biochemistry, 2012
amino acid residues within the short arm region of alpha5 that were critical for neurite outgrowth activity
Screening of integrin-binding peptides from the laminin α4 and α5 chain G domain peptide library.
Nomizu et al., Hachiōji, Japan. In Arch Biochem Biophys, 2012
most of the integrin-mediated cell adhesive peptides are located in the loop regions in the G domains, suggesting that structure is important for the integrin specific recognition
Laminin-511 expression is associated with the functionality of feeder cells in human embryonic stem cell culture.
Skottman et al., Tampere, Finland. In Stem Cell Res, 2012
These results indicate specific laminin isoforms and integrins in maintenance of human embryonic stem cells pluripotency in feeder-dependent cultures.
Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice.
Simon-Assmann et al., Strasbourg, France. In Plos One, 2011
mechanistic role of laminin-511 in tissue homeostasis
[Molecular basis of red blood cell adhesion to endothelium].
Wautier et al., Paris, France. In Ann Pharm Fr, 2011
This mutation stimulates erythropoiesis and is the cause of Lu/BCAM (CD239) phosphorylation, which potentiated the interaction with laminin alpha 5.
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511.
Tryggvason et al., Stockholm, Sweden. In Nat Biotechnol, 2010
We describe a system for culturing human embryonic stem (hES) cells and induced pluripotent stem (iPS) cells on a recombinant form of human laminin-511, a component of the natural hES cell niche.
Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.
Sorokin et al., Münster, Germany. In Nat Med, 2009
Laminin alpha5 directly inhibits integrin alpha(6)beta(1)-mediated migration of T lymphocytes through laminin alpha4.
Laminin-332 and -511 in skin.
Kobayashi et al., Ōsaka, Japan. In Exp Dermatol, 2008
Keratinocytes of the skin secrete numerous laminin isoforms, including laminin-511 and laminin-332.
Laminin isoforms and lung development: all isoforms are not equal.
Senior et al., Saint Louis, United States. In Dev Biol, 2006
In vivo studies of laminin alpha5-deficient mice indicate that this laminin chain, found in laminins 511 and 521, is essential for normal lobar septation in early lung development and normal alveolization and distal epithelial cell differentiation and maturation in late lung development.
Expression and function of laminins in the embryonic and mature vasculature.
Sorokin et al., Lund, Sweden. In Physiol Rev, 2005
Laminin 10 (composed of laminin alpha5, beta1, and gamma1 chains) is detectable primarily in endothelial cell basement membranes of capillaries and venules commencing 3-4 wk after birth.
An agrin minigene rescues dystrophic symptoms in a mouse model for congenital muscular dystrophy.
Ruegg et al., Basel, Switzerland. In Nature, 2001
Here we show that this mini-agrin-which binds to basement membrane and to alpha-dystroglycan, a member of the DGC-amends muscle pathology by a mechanism that includes agrin-mediated stabilization of alpha-dystroglycan and the laminin alpha5 chain.
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