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Lamin B2

lamin B2, LMNB2
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B2. This gene is in a head-to-tail orientation with the gene for the translocase of inner mitochondrial membrane 13 homolog gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, c-Myc, lamin A/C, HAD, ROD
Papers using lamin B2 antibodies
A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation
Vaux David J. et al., In The Journal of Cell Biology, 1987
... Primary antibodies used included anti–lamin B1 (Chemicon), anti–lamin A/C (Novocastra), anti–lamin B2 (Novocastra), and anti-GFP (CLONTECH Laboratories, Inc.) ...
Papers on lamin B2
Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy.
Goldman et al., Chicago, United States. In Mol Biol Cell, Dec 2015
In fibroblasts null for the expression of either lamins A/C or lamin B1, the remaining lamin meshworks are altered compared with the lamin meshworks in wild-type nuclei or nuclei lacking lamin B2.
Mutation of the nuclear lamin gene LMNB2 in progressive myoclonus epilepsy with early ataxia.
Hildebrand et al., Melbourne, Australia. In Hum Mol Genet, Sep 2015
Fourteen candidate genes were screened by conventional Sanger sequencing and in one, LMNB2, a novel homozygous missense mutation was identified that segregated with the PME in the family.
Xenopus LAP2β protein knockdown affects location of lamin B and nucleoporins and has effect on assembly of cell nucleus and cell viability.
Rzepecki et al., Wrocław, Poland. In Protoplasma, Aug 2015
Knockdown of the XLAP2β protein expression in XTC cells by synthetic siRNA and plasmid encoded siRNA resulted in nuclear abnormalities including changes in shape of nuclei, abnormal chromatin structure, loss of nuclear envelope, mislocalization of integral membrane proteins of INM such as lamin B2, mislocalization of nucleoporins, and cell death.
Transcriptional regulatory network of SOX4 during myoblast differentiation.
Choi et al., Seoul, South Korea. In Biochem Biophys Res Commun, Aug 2015
Lamin B2, barrier to autointegration factor 1, and apolipoprotein C-III were identified as novel interacting partners of SOX4 by yeast two-hybrid screening, and the genes encoding lysosomal-associated membrane protein 1, ubiquitin-conjugating enzyme E2S, and Map2k2 were identified as putative target genes of SOX4.
The Proteomic Analysis of Human Placenta with Pre-eclampsia and Normal Pregnancy.
Kim et al., Suwŏn, South Korea. In J Korean Med Sci, Jun 2015
In preeclamptic placenta 9 differentially expressed proteins were down-regulated with Hsp 70, serum albumin crystal structure chain A, lamin B2, cytokeratin 18, actin cytoplasmic, alpha fibrinogen precursor, septin 2, dihydrolipoamide branched chain transacylase E2 and firbrinogen beta chain.
Quantitative proteomic analysis of the metastasis-inhibitory mechanism of miR-193a-3p in non-small cell lung cancer.
Yao et al., Shanghai, China. In Cell Physiol Biochem, 2014
Among them, the up-regulated levels of expression of two of the 62 proteins with up-regulated expression (PPP2R2A and GSN) and the down-regulated levels of expression four of the 50 proteins with down-regulated expression (LMNB2, UHRF1, G3BP1, and HNRNPU) were verified using western blotting.
Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression.
Taimen et al., Turku, Finland. In Plos One, 2014
Low expression of lamin B2 correlated with lymph node positivity (p<0.01) and predicted unfavorable DSS (HR = 0.4; 95% CI 0.2-1.0;
Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration.
Atiomo et al., Nottingham, United Kingdom. In Fertil Steril, 2012
These biomarkers include calreticulin, fibrinogen-γ, superoxide dismutase, vimentin, malate dehydrogenase, and lamin B2.
Local translation of extranuclear lamin B promotes axon maintenance.
Holt et al., Cambridge, United Kingdom. In Cell, 2012
The intermediate filament protein lamin B2 (LB2), normally associated with the nuclear membrane, was identified as an unexpected major target.
A Chinese patient with acquired partial lipodystrophy caused by a novel mutation with LMNB2 gene.
Luo et al., Wuhan, China. In J Pediatr Endocrinol Metab, 2011
Mutation in LMNB2 gene is associated with partial lipodystrophy.
Laminopathies and lamin-associated signaling pathways.
Lattanzi et al., Bologna, Italy. In J Cell Biochem, 2011
Studies indicate that the lamin-binding proteins implicated in laminopathies include lamin B2 and nuclear envelope proteins.
Characterization of the head-to-tail overlap complexes formed by human lamin A, B1 and B2 "half-minilamin" dimers.
Herrmann et al., Basel, Switzerland. In J Mol Biol, 2010
These findings indicate that a lamin dimer principally has the freedom for a "combinatorial" head-to-tail association with all types of lamins, a property that might be of significant importance for the assembly of the nuclear lamina.
DNA replication, development and cancer: a homeotic connection?
Biamonti et al., Pisa, Italy. In Crit Rev Biochem Mol Biol, 2010
A one-hybrid screen to detect proteins with affinity for the lamin B2 replication origin identified three homeotic proteins, namely HoxA13, HoxC10 and HoxC13.
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Turck et al., São Paulo, Brazil. In Eur Arch Psychiatry Clin Neurosci, 2009
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Molecular and structural transactions at human DNA replication origins.
Riva et al., Trieste, Italy. In Cell Cycle, 2007
The modulation of topology around the origin sequence plays an essential role in the function of the human lamin B2 origin and the two topoisomerases interact specifically with it in a cell-cycle modulated way.
"Laminopathies": a wide spectrum of human diseases.
Bonne et al., New York City, United States. In Exp Cell Res, 2007
Duplication in LMNB1 encoding lamin B1 causes autosomal dominant leukodystrophy and mutations in LMNB2 encoding lamin B2 are associated with acquired partial lipodystrophy.
Functional interactions of DNA topoisomerases with a human replication origin.
Falaschi et al., Trieste, Italy. In Embo J, 2007
The human DNA replication origin, located in the lamin B2 gene, interacts with the DNA topoisomerases I and II in a cell cycle-modulated manner.
Human laminopathies: nuclei gone genetically awry.
Collins et al., Bethesda, United States. In Nat Rev Genet, 2006
Few genes have generated as much recent interest as LMNA, LMNB1 and LMNB2, which encode the components of the nuclear lamina.
Start sites of bidirectional DNA synthesis at the human lamin B2 origin.
Falaschi et al., Trieste, Italy. In Science, 2000
The initiation sites of bidirectional synthesis at the DNA replication origin located at the 3' end of the human lamin B2 gene were investigated.
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