Mucosal plasma cell barrier disruption during intestine transplant rejection.
Pittsburgh, United States. In Transplantation, 2013
RESULTS: Among 107 differentially expressed genes, three B-cell lineage-specific genes, CCR10, STAP1, and IGLL1, were down-regulated during ITx rejection and were selected for and achieved technical quantitative reverse transcription polymerase chain reaction replication.
Impact of delay to cryopreservation on RNA integrity and genome-wide expression profiles in resected tumor samples.
Lyon, France. In Plos One, 2012
In HCC, a signature of 6 up-regulated genes (CYP2E1, IGLL1, CABYR, CLDN2, NQO1, SCL13A5) and 6 down-regulated genes (MT1G, MT1H, MT1E, MT1F, HABP2, SPINK1) was identified (FDR <0.05).
Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis.
China. In Genet Mol Biol, 2012
The genes in these pathways, e.g., ZAP70, IGLL1, CD79A, COL6A3, COL3A1, COL1A1, CYP2C18 and CYP2C9, may be considered as potential therapeutic targets for gastric cancer.
Primary B cell immunodeficiencies: comparisons and contrasts.
Memphis, United States. In Annu Rev Immunol, 2008
Mutations in Btk, components of the pre-B cell and B cell receptor (lambda5, Igalpha, Igbeta), or the scaffold protein BLNK account for approximately 90% of patients with defects in early B cell development.
Structural insight into pre-B cell receptor function.
Stanford, United States. In Science, 2007
In the 2.7 angstrom structure of a human pre-BCR Fab-like fragment, consisting of an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an antibody light chain and appear to "probe" the HC CDR3, potentially influencing the selection of the antibody repertoire.
Aiolos: an ungrateful member of the Ikaros family.
London, United Kingdom. In Immunity, 2007
Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance.
The kappa-like pre-B receptor: surplus biology or a missing link?
Houston, United States. In Semin Immunol, 2006
The present review discusses the concept of the alternative usage of kappa-like pre-B cell receptors and classical pre-B cell receptors utilizing the lambda-like surrogate light chain composed of lambda5 and VpreB.