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Immunoglobulin lambda-like polypeptide 1

lambda5, IGLL1
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: VpreB, BCR, CAN, IL-7, EBF
Papers on lambda5
Expression of estrus modifies the gene expression profile in reproductive tissues on Day 19 of gestation in beef cows.
New
Cerri et al., Vancouver, Canada. In Theriogenology, Nov 2015
The majority of transcripts affected by estrous expression in the endometrium belong to the immune system and adhesion molecule family (MX1, MX2, MYL12A, MMP19, CXCL10, IGLL1, and SLPI; P ≤ 0.05), as well as those related with prostaglandin synthesis (OTR and COX-2; P ≤ 0.05).
Overlap Chronic Placental Inflammation Is Associated with a Unique Gene Expression Pattern.
Terry et al., Hamilton, Canada. In Plos One, 2014
In addition, IGLL1, CXCL13, CD27, CXCL9, ICOS, and KLRC1 had increased expression in the inflamed placental samples.
Diagnostics of primary immunodeficiency diseases: a sequencing capture approach.
Nilsson et al., Uppsala, Sweden. In Plos One, 2013
Causal mutations identified in the unknown patient samples were located in STAT3, IGLL1, RNF168 and PGM3.
Mucosal plasma cell barrier disruption during intestine transplant rejection.
Sindhi et al., Pittsburgh, United States. In Transplantation, 2013
RESULTS: Among 107 differentially expressed genes, three B-cell lineage-specific genes, CCR10, STAP1, and IGLL1, were down-regulated during ITx rejection and were selected for and achieved technical quantitative reverse transcription polymerase chain reaction replication.
Impact of delay to cryopreservation on RNA integrity and genome-wide expression profiles in resected tumor samples.
Le Calvez-Kelm et al., Lyon, France. In Plos One, 2012
In HCC, a signature of 6 up-regulated genes (CYP2E1, IGLL1, CABYR, CLDN2, NQO1, SCL13A5) and 6 down-regulated genes (MT1G, MT1H, MT1E, MT1F, HABP2, SPINK1) was identified (FDR <0.05).
Identification of significant pathways in gastric cancer based on protein-protein interaction networks and cluster analysis.
Chen et al., China. In Genet Mol Biol, 2012
The genes in these pathways, e.g., ZAP70, IGLL1, CD79A, COL6A3, COL3A1, COL1A1, CYP2C18 and CYP2C9, may be considered as potential therapeutic targets for gastric cancer.
The non-Ig parts of the VpreB and λ5 proteins of the surrogate light chain play opposite roles in the surface representation of the precursor B cell receptor.
GeneRIF
Ohnishi et al., Berlin, Germany. In J Immunol, 2012
the non-Ig part of lambda5 crosslinks precursor b-cell receptors for downregulation and stimulation.
Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage.
Impact
Dillon et al., London, United Kingdom. In Cell Stem Cell, 2010
In ESCs, Sox2 contributes to the formation of a monovalent mark at an enhancer in the pro/pre-B cell-specific lambda5-VpreB1 locus.
The unique and immunoglobulin-like regions of surrogate light chain component lambda5 differentially interrogate immunoglobulin heavy-chain structure.
GeneRIF
Roman et al., United States. In Mol Immunol, 2010
lambda5 differentially relies on the lambda-like Ig and unique region to probe H chain structure to best accommodate diversity among H chains.
Deviation of the B cell pathway in senescent mice is associated with reduced surrogate light chain expression and altered immature B cell generation, phenotype, and light chain expression.
GeneRIF
Riley et al., Miami, United States. In J Immunol, 2009
Reduced surrogate light chain expression contributes to decreased production of pre-B lymphocytes in aged bone marrow and in young lambda5 gene knockout mice.
Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells.
Impact
Jumaa et al., Freiburg, Germany. In Immunity, 2009
We found that the pre-BCR was capable of recognizing multiple self-antigens and that a signaling-deficient pre-BCR lacking the non-Ig region of the surrogate-light-chain component lambda5 was rescued by the complementarity-determining region 3 derived from heavy chains of polyreactive receptors.
Primary B cell immunodeficiencies: comparisons and contrasts.
Review
Impact
Campana et al., Memphis, United States. In Annu Rev Immunol, 2008
Mutations in Btk, components of the pre-B cell and B cell receptor (lambda5, Igalpha, Igbeta), or the scaffold protein BLNK account for approximately 90% of patients with defects in early B cell development.
Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling.
Impact
Hendriks et al., Rotterdam, Netherlands. In Immunity, 2007
The pre-B cell receptor (pre-BCR), composed of immunoglobulin mu heavy chain and the surrogate light chain (SLC) proteins lambda5 and Vpreb, signals for proliferation and maturation of developing pre-B cells.
Structural insight into pre-B cell receptor function.
Impact
Garcia et al., Stanford, United States. In Science, 2007
In the 2.7 angstrom structure of a human pre-BCR Fab-like fragment, consisting of an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an antibody light chain and appear to "probe" the HC CDR3, potentially influencing the selection of the antibody repertoire.
Aiolos: an ungrateful member of the Ikaros family.
Review
Impact
Kioussis, London, United Kingdom. In Immunity, 2007
Thompson et al. (2007) show that pre-BCR signaling induces Aiolos expression, which in turn suppresses the expression of the pre-BCR component lambda5 and eliminates the very structure that signaled its appearance.
Powered by pairing: the surrogate light chain amplifies immunoglobulin heavy chain signaling and pre-selects the antibody repertoire.
Review
Jäck et al., Erlangen, Germany. In Semin Immunol, 2006
However, enhanced signaling necessary for pre-B cell expansion requires cross-linking of pre-BCRs via the non-immunoglobulin tail of SLC's subunit lambda5.
The kappa-like pre-B receptor: surplus biology or a missing link?
Review
Martinez-Valdez et al., Houston, United States. In Semin Immunol, 2006
The present review discusses the concept of the alternative usage of kappa-like pre-B cell receptors and classical pre-B cell receptors utilizing the lambda-like surrogate light chain composed of lambda5 and VpreB.
The pre-B cell receptor and its function during B cell development.
Review
Lu et al., Hong Kong, Hong Kong. In Cell Mol Immunol, 2004
The pre-BCR, transiently expressed by developing precursor B cells, comprises the Ig muH chain, surrogate light (SL) chains VpreB and lambda5, as well as the signal-transducing heterodimer Ig alpha/Ig beta.
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