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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Lipase A, lysosomal acid, cholesterol esterase

LAL, lysosomal acid lipase, LIPA, CESD, cholesteryl esterase, cholesterol ester hydrolase
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using LAL antibodies
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
Fritz Jörg Hermann, In PLoS ONE, 2002
... The Limulus Amebocyte Lysate (LAL) assay was performed with a GenScript Chromogenic LAL endotoxin assay ...
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
Sambhara Suryaprakash, In PLoS ONE, 2000
... Endotoxin levels were measured using the ToxinSensor™ chromogenic LAL endotoxin assay kit from GenScript (Piscataway, NJ) ...
Papers on LAL
Macrophage-specific transgenic expression of cholesteryl ester hydrolase attenuates hepatic lipid accumulation and also improves glucose tolerance in ob/ob mice.
Ghosh et al., Richmond, United States. In Am J Physiol Endocrinol Metab, 2012
Transgenic overexpression of CEH in macrophages polarizes hepatic macrophages (Kupffer cells) to an anti-inflammatory M2 phenotype that attenuates hepatic lipid synthesis and accumulation.
Lysosomal lipase deficiency: molecular characterization of eleven patients with Wolman or cholesteryl ester storage disease.
Calandra et al., Reggio nell'Emilia, Italy. In Mol Genet Metab, 2012
study identified two novel mutations of LIPA gene in Wolman Disease patients which abolished the expression of LAL enzyme; also found that all cholesteryl ester storage disease patients carried the common mutant allele c.894G>A
Intragenic deletion as a novel type of mutation in Wolman disease.
Chung et al., New York City, United States. In Mol Genet Metab, 2011
a novel paternally inherited c.482delA mutation in exon 5 of Lipase A that results in a frameshift mutation at amino acid 161 is reported in a fatal case of Wolman disease
Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice.
Du et al., Indianapolis, United States. In Plos One, 2011
analysis of important gene pathways involved in the myeloid lineage cells towards MDSCs using lal-/- mouse model
Myeloid-specific expression of human lysosomal acid lipase corrects malformation and malfunction of myeloid-derived suppressor cells in lal-/- mice.
Du et al., Indianapolis, United States. In J Immunol, 2011
studies demonstrate that LAL in myeloid cells plays a critical role in maintaining normal hematopoietic cell development and balancing immunosuppression and inflammation
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