gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Leukocyte-associated immunoglobulin-like receptor 2

LAIR-2, CD306
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to LAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The function of this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: LAIR-1, CAN, V1a, CD45, HAD
Papers on LAIR-2
Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus.
Petzl-Erler et al., Curitiba, Brazil. In Hum Genet, Feb 2016
LAIR-2 is a soluble homolog that antagonizes LAIR-1 inhibitory function by binding the same ligands.
Comparison of LAIR-1 genetic pathways in murine vs human internal organs.
Sun et al., Harbin, China. In Gene, 2014
Moreover, we found that the in vivo interaction of LAIR-1 with LAIR-2 rarely occurs, implying that the species difference in LAIR-1 genetic pathways could not be primarily attributed to the existence of human LAIR-2.
Development of a quantitative ELISA kit for human secreted CD306/LAIR-2 and its application.
Zhu et al., Shanghai, China. In Chin J Nat Med, 2014
AIM: A quantitative ELISA kit for the detection of human secreted CD306/LAIR-2 was developed using monoclonal and polyclonal antibodies which were raised against a highly purified recombinant human secreted CD306/LAIR-2.
Leukocyte-associated Ig-like receptor-1 is a novel inhibitory receptor for surfactant protein D.
Meyaard et al., Utrecht, Netherlands. In J Leukoc Biol, 2014
Binding assays show that SP-D interacts via its collagenous domain with LAIR-1 and the related LAIR-2.
Trophoblasts and decidual stromal cells regulate decidual NK cell functions via interaction between collagen and LAIR-1.
Li et al., Shanghai, China. In Am J Reprod Immunol, 2014
Co-culture of dNKs with HTR-8/DSCs up-regulated LAIR-1 on dNKs that could be attenuated by pre-treatment with LAIR-2, a competitive inhibitor of LAIR-1.
A non-stimulatory monoclonal antibody against the inhibitory immunoreceptor LAIR-1.
Jin et al., Xi'an, China. In Monoclon Antib Immunodiagn Immunother, 2014
The human leukocyte-associated Ig-like receptor (LAIR) family contains two members: LAIR-1 (CD305) and LAIR-2 (CD306).
Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2.
Meyaard et al., Utrecht, Netherlands. In J Innate Immun, 2013
Previously, we described binding of the inhibitory receptor LAIR-1 and its soluble family member LAIR-2 to collagen.
Development and evaluation of a sandwich ELISA method for the detection of human CD306.
Jin et al., Xi'an, China. In J Immunol Methods, 2013
CD306, also known as soluble leukocyte-associated immunoglobulin-like receptor-2 (LAIR-2), is a member of an immunoglobulin superfamily with the shared characteristic of an immunoglobulin-like C2-type domain.
LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion.
Parks et al., Pittsburgh, United States. In Placenta, 2013
Leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) was identified on a global gene expression microarray analysis of surplus chorionic villus sampling (CVS) tissues as down-regulated in the first trimester of preeclampsia pregnancies.
Serum LAIR-2 is increased in autoimmune thyroid diseases.
Saverino et al., Genova, Italy. In Plos One, 2012
In addition to LAIR-1, the human genome encodes LAIR-2, a soluble homolog.
C1q limits dendritic cell differentiation and activation by engaging LAIR-1.
Diamond et al., United States. In Proc Natl Acad Sci U S A, 2012
Binding analyses in cell-free systems and on the cell membrane demonstrate that C1q and its collagen tail associate with LAIR-1 and LAIR-2 (CD306), a soluble inhibitor of LAIR-1.
A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis.
López-Larrea et al., Oviedo, Spain. In Ann Rheum Dis, 2012
Two markers in two different genes (CNOT3 and LAIR2) showed significant association with ankylosing spondylitis.
Enhanced secretion of leukocyte-associated immunoglobulin-like receptor 2 (LAIR-2) and soluble LAIR-1 in rheumatoid arthritis: LAIR-2 is a more efficient antagonist of the LAIR-1-collagen inhibitory interaction than is soluble LAIR-1.
Meyaard et al., Utrecht, Netherlands. In Arthritis Rheum, 2011
Plasma, urine, and synovial fluid were screened for the presence of sLAIR-1 and LAIR-2 by enzyme-linked immunosorbent assay.
Genome-wide expression profile of first trimester villous and extravillous human trophoblast cells.
Moffett et al., Cambridge, United Kingdom. In Placenta, 2011
We show that decidual T-cells, macrophages and NK cells express the inhibitory collagen receptor LAIR-1 and that EVT secrete LAIR-2, which can block this interaction.
Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member.
Meyaard et al., Le Kremlin-Bicêtre, France. In Plos One, 2009
LAIR-2/Fc has the capacity to interfere with platelet-collagen interactions mediated by Glycoprotein VI and the VWF/Glycoprotein Ib axis.
Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III.
Meyaard et al., Utrecht, Netherlands. In Matrix Biol, 2009
Human collagen II peptides II-17, -27, -30, -35, -38, -42, -49 & -56; and collagen III peptides III-1, 5, -8, -10, -12, -13, -22, -30, -38, -40, -44, -45, and -51 specifically interacted with hLAIR-2 expressed on K562 cells
The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction.
Meyaard et al., Utrecht, Netherlands. In J Immunol, 2008
LAIR-2 prevents binding of human LAIR-1 to collagens and LAIR-1 cross-linking in vitro, suggesting that the protein has an immunoregulatory function in vivo.
share on facebooktweetadd +1mail to friends