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Leukocyte-associated immunoglobulin-like receptor 1

LAIR-1, leukocyte-associated Ig-like receptor-1, L air, leukocyte-associated immunoglobulin-like receptor-1, CD305
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, fibrillin-1, LAIR-2, V1a
Papers on LAIR-1
Differential gene expression levels might explain association of LAIR2 polymorphisms with pemphigus.
New
Petzl-Erler et al., Curitiba, Brazil. In Hum Genet, Feb 2016
The leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) is a collagen-binding inhibitory receptor important for the regulation of immune responses, expressed on the majority of peripheral blood mononuclear cells (PBMC).
Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors.
New
Gao et al., Beijing, China. In Proc Natl Acad Sci U S A, Feb 2016
As a member of the leukocyte receptor complex family of proteins, OSCAR shares a high degree of sequence and structural homology with other collagen receptors of this family, including glycoprotein VI, leukocyte-associated Ig-like receptor-1, and leukocyte Ig-like receptor B4, but recognizes a unique collagen sequence.
Assessment of Toxicity, Antifeedant Activity, and Biochemical Responses in Stored-Grain Insects Exposed to Lethal and Sublethal Doses of Gaultheria procumbens L. Essential Oil.
New
Prakash et al., Mysore, India. In J Agric Food Chem, Jan 2016
EO and its major compound methyl salicylate (MS) showed 100% mortality at 150 and 5.0 μL/L air against S. oryzae and R. dominica, respectively, on 24 h of exposure.
Essential Oil of Amomum maximum Roxb. and Its Bioactivities against Two Stored-Product Insects.
New
Lei et al., Beijing, China. In J Oleo Sci, Jan 2016
mg/L air, respectively) and showed contact toxicity against L. bostrychophila (LD50 = 67.46
Structural basis for collagen recognition by the immune receptor OSCAR.
New
Herr et al., Cambridge, United Kingdom. In Blood, Dec 2015
Direct binding assays, combined with site-directed mutagenesis, confirm that the primary collagen-binding site in OSCAR resides in D2, in marked contrast to the related collagen receptors, GPVI and LAIR-1.
The metabolic cost of breathing in red-eared sliders: An attempt to resolve an old controversy.
New
Milsom et al., Vancouver, Canada. In Respir Physiol Neurobiol, Nov 2015
The unidirectional ventilation method yielded an estimate of 3.3ml O2/L air ventilated while the regression method (using hypoxia as a respiratory stimulus) produced an estimate of 0.8ml O2/L air ventilated when corrected for hypoxia-induced metabolic suppression.
Intracerebral Distribution of a-Pinene and the Anxiolytic-like Effect in Mice Following Inhaled Administration of Essential Oil from Chamaecyparis obtuse.
New
Koike et al., In Nat Prod Commun, Aug 2015
With inhaled administration of 32 μL/L air EOCO, a high concentration of α-pinene was observed.
Chemical Compositions and Insecticidal Activities of Alpinia kwangsiensis Essential Oil against Lasioderma serricorne.
Du et al., Nanning, China. In Molecules, 2014
During the assay, it was shown that the essential oil exhibited both potential contact (LD50 = of 24.59 μg/adult) and fumigant (LC50 = of 9.91 mg/L air) toxicity against Lasioderma serricorne.
Development, evaluation and comparison of two independent sampling and analytical methods for ortho-phthalaldehyde vapors and condensation aerosols in air.
Tucker, Cincinnati, United States. In Anal Methods, 2014
The estimated detection limit is 0.016 µg per sample or 0.067 µg m(-3) (0.012 ppb) for a 240 L air sample.
Leukocyte-associated Ig-like receptor-1-deficient mice have an altered immune cell phenotype.
GeneRIF
Coligan et al., Rockville, United States. In J Immunol, 2012
LAIR-1-deficient mice are healthy and fertile with normal longevity, showing increased numbers of splenic B, regulatory T, and dendritic cells.
Defective expression and function of the leukocyte associated Ig-like receptor 1 in B lymphocytes from systemic lupus erythematosus patients.
GeneRIF
Poggi et al., Genova, Italy. In Plos One, 2011
Loss of LAIR-1 function is associated with systemic lupus erythematosus
[Mast cell inhibitory receptors].
Review
Brzezińska-Błaszczyk et al., Łódź, Poland. In Postepy Hig Med Dosw (online), 2011
The scope of this paper is to present the current knowledge on mast cell-associated inhibitory receptors, such as FcγRIIB, paired immunoglobulin-like receptor B (PIR-B), CD300, CD172a, gp49B1, CD200R, sialic acid-binding immunoglobulin-like lectin (Siglec) molecules, CD305, allergin-1, mast cell function-associated antigen (MAFA), and CD72.
Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR-1.
GeneRIF
Meyaard et al., Utrecht, Netherlands. In Mol Immunol, 2011
tumor-expressed collagens can bind and trigger immune inhibitory signaling via LAIR-1, suggesting that collagens indeed may affect tumor immune evasion.
Leukocyte-associated immunoglobulin-like receptor-1 is expressed on human megakaryocytes and negatively regulates the maturation of primary megakaryocytic progenitors and cell line.
GeneRIF
Fu et al., Yantai, China. In Biochem Biophys Res Commun, 2011
These results suggest that LAIR-1 is a likely candidate for an early marker of megakaryocytes differentiation, and provide initial evidence indicating that LAIR-1 serves as a negative regulator of megakaryocytopoiesis.
Transmembrane collagen receptors.
Review
Leitinger, London, United Kingdom. In Annu Rev Cell Dev Biol, 2010
A structurally diverse group of transmembrane receptors mediates the recognition of the collagen triple helix: integrins, discoidin domain receptors, glycoprotein VI, and leukocyte-associated immunoglobulin-like receptor-1.
The immune inhibitory receptor LAIR-1 is highly expressed by plasmacytoid dendritic cells and acts complementary with NKp44 to control IFNα production.
GeneRIF
Ferlazzo et al., Messina, Italy. In Plos One, 2009
Data show that pDCs isolated from peripheral blood of systemic lupus erithematosus (SLE) patients express lower levels of LAIR-1 while displaying slight but consistent expression of NKp44.
The inhibitory collagen receptor LAIR-1 (CD305).
Review
GeneRIF
Meyaard, Utrecht, Netherlands. In J Leukoc Biol, 2008
A receptor that potentially is able to regulate multiple steps of an immune response.[REVIEW]
Non-MHC ligands for inhibitory immune receptors: novel insights and implications for immune regulation.
Review
Meyaard et al., Utrecht, Netherlands. In Mol Immunol, 2007
However, the recent identification of non-MHC class I ligands for inhibitory immune receptors, such as KLRG1, KLRB1 and LAIR-1, indicates that also MHC class I-independent inhibitory immune receptors play crucial roles in inducing peripheral tolerance.
EpCAM: A new therapeutic target for an old cancer antigen.
Review
Eck et al., Philadelphia, United States. In Cancer Biol Ther, 2003
Neoplastic cells that interact with this receptor, named LAIR-1, may enact an immunologic escape, and thus confer a selective advantage for their growth and spread.
LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.
Impact
Phillips et al., Palo Alto, United States. In Immunity, 1997
In the present study, we describe a novel inhibitory receptor, leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes.
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