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LAG1 Lag1p

LAG1, Lag1p, LASS1, CerS1, uog1
This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. Members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in yeast suggest that the encoded protein is involved in aging. This protein is transcribed from a monocistronic mRNA as well as a bicistronic mRNA, which also encodes growth differentiation factor 1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, T1L, ACID, LASS5, l-3
Papers using LAG1 antibodies
Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality.
Supplier
Kim Stuart K., In PLoS Genetics, 2003
... in yeast, LAG1, regulates its lifespan and is homologous to ...
Papers on LAG1
Synthesis and biological evaluation of analogs of AAL(S) for use as ceramide synthase 1 inhibitors.
New
Morris et al., Sydney, Australia. In Org Biomol Chem, Jan 2016
Our results have identified inhibitors which are non-cytotoxic yet maintain CerS1 inhibition.
Histological analyses by matrix-assisted laser desorption/ionization-imaging mass spectrometry reveal differential localization of sphingomyelin molecular species regulated by particular ceramide synthase in mouse brains.
New
Kuge et al., Sapporo, Japan. In Biochim Biophys Acta, Dec 2015
Furthermore, a combination study using in situ hybridization and IMS revealed the spatial expression of CerS1 to be associated with the localization of SM (d18:1/18:0) in cell body-rich gray matter, and CerS2 to be associated with SM (d18:1/24:1) in myelin-rich white matter.
SIRT3 Deacetylates Ceramide Synthases: Implications for Mitochondrial Dysfunction and Brain Injury.
New
Gudz et al., United States. In J Biol Chem, Dec 2015
Reciprocal immunoprecipitation experiments revealed that CerS1, CerS2 and CerS6, but not CerS4, are associated with SIRT3 in cerebral mitochondria.
Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
New
Obeid et al., New York City, United States. In J Biol Chem, Nov 2015
Ceramide synthases (CerS1-CerS6), which catalyze the N-acylation of the (dihydro)sphingosine backbone to produce (dihydro)ceramide in both the de novo and the salvage or recycling pathway of ceramide generation, have been implicated in the control of programmed cell death.
The Influence of Asian Dust, Haze, Mist, and Fog on Hospital Visits for Airway Diseases.
New
Kim et al., Seoul, South Korea. In Tuberc Respir Dis (seoul), Oct 2015
Hospital visits for asthma significantly increased at lag0 and lag1 for Asian dust (relative risk [RR], 1.10; 95% confidence interval [CI], 1.01-1.19;
Tilt Aftereffect due to Adaptation to Natural Images.
New
Sagi et al., In J Vis, Oct 2015
TAE was strongest immediately after image exposure (lag1: 1.44º, ~1.5 sec), minimal on the following trial (lag2: 0.46º, ~3 sec), converging to an intermediate value (0.98º) on later trials.
Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging.
Review
New
Jazwinski, New Orleans, United States. In Ageing Res Rev, Sep 2015
The yeast LAG1 ceramide synthase gene was the first longevity gene cloned as such, and its orthologs hyl-1 and hyl-2 determine worm lifespan.
Endocannabinoid and ceramide levels are altered in patients with colorectal cancer.
New
Ren et al., Xiamen, China. In Oncol Rep, Jul 2015
Levels of two enzymes participating in the biosynthesis and degradation of AEA, N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NPLD) and fatty acid amide hydrolase (FAAH), together with the most abundant ceramide synthases (CerS1, CerS2, CerS5 and CerS6) in the colon were also determined.
Individual Effect Modifiers of Dust Exposure Effect on Cardiovascular Morbidity.
Novack et al., Beersheba, Israel. In Plos One, 2014
for a 10 μg/m3 increase, while a delayed response (lag1) was found during the dust storm days; OR = 1.007 (95%CI 1.002-1.012).
Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.
Impact
Brüning et al., Köln, Germany. In Cell Metab, 2014
Ceramides vary in acyl-chain lengths from C14:0 to C30:0 and are synthesized by six ceramide synthase enzymes (CerS1-6).
Analyzing Multiple Multivariate Time Series Data Using Multilevel Dynamic Factor Models.
Zhang et al., United States. In Multivariate Behav Res, 2014
To illustrate the uses of MDFMs, we applied lag0, lag1, and lag2 MDFMs to empirical data on affect collected from 205 dating couples who had at least 50 consecutive days of observations.
Diverse functions of ceramide in cancer cell death and proliferation.
Review
Ogretmen et al., Charleston, United States. In Adv Cancer Res, 2012
For example, different fatty-acid chain lengths of ceramide, such as C(16)-ceramide that can be generated by ceramide synthase 6 (CerS6), have been implicated in cancer cell proliferation, whereas CerS1-generated C(18)-ceramide mediates cell death.
Ceramide synthases at the centre of sphingolipid metabolism and biology.
Review
Obeid et al., Charleston, United States. In Biochem J, 2012
Six mammalian CerSs (CerS1-CerS6) have been identified.
Concerted functions of HDAC1 and microRNA-574-5p repress alternatively spliced ceramide synthase 1 expression in human cancer cells.
GeneRIF
Ogretmen et al., United States. In Embo Mol Med, 2012
Moreover, an alternatively spliced variant CerS1 mRNA (CerS1-2) was detected mainly in cancer cells or primary tumour tissues compared to controls, which was targeted by miR-574-5p for degradation
HRAS1 and LASS1 with APOE are associated with human longevity and healthy aging.
GeneRIF
Georgia Centenarian Study and the Louisiana Healthy Aging Study et al., New Orleans, United States. In Aging Cell, 2010
The variation in LASS1 is functional, causing enhanced expression of the gene, and it contributes to healthy aging and greater survival in the tenth decade of life.
Stress-induced ER to Golgi translocation of ceramide synthase 1 is dependent on proteasomal processing.
GeneRIF
Alexander et al., Columbia, United States. In Exp Cell Res, 2010
The study suggests that diverse stresses initiate responses through different signaling pathways, which ultimately converge to regulate CerS1 localization.
Ceramide biosynthesis in keratinocyte and its role in skin function.
Review
Igarashi et al., Sapporo, Japan. In Biochimie, 2009
We also describe recent studies that identified the family of CerS (CerS1-CerS6) in mammals.
The longevity assurance homologue of yeast lag1 (Lass) gene family (review).
Review
Malik et al., Mainz, Germany. In Int J Mol Med, 2009
The founding member, lag1, was discovered in a screen for yeast longevity genes.
Transmembrane topology of ceramide synthase in yeast.
GeneRIF
Riezman et al., Genève, Switzerland. In Biochem J, 2006
the topology of the Lag1p and Lac1p subunits of ceramide synthase was investigated
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.
GeneRIF
Ogretmen et al., Charleston, United States. In J Biol Chem, 2004
LAG1 and C18-ceramide have roles in the regulation of growth of HNSCC
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