Endocannabinoid and ceramide levels are altered in patients with colorectal cancer.
Xiamen, China. In Oncol Rep, Jul 2015
Levels of two enzymes participating in the biosynthesis and degradation of AEA, N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NPLD) and fatty acid amide hydrolase (FAAH), together with the most abundant ceramide synthases (CerS1, CerS2, CerS5 and CerS6) in the colon were also determined.
Diverse functions of ceramide in cancer cell death and proliferation.
Charleston, United States. In Adv Cancer Res, 2012
For example, different fatty-acid chain lengths of ceramide, such as C(16)-ceramide that can be generated by ceramide synthase 6 (CerS6), have been implicated in cancer cell proliferation, whereas CerS1-generated C(18)-ceramide mediates cell death.