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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 23 Nov 2016.

Lactotransferrin

Lactoferrin
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: CD45, CAN, HAD, Transferrin, ACID
Papers on Lactoferrin
Ultrastructural effects and antibiofilm activity of LFchimera against Burkholderia pseudomallei.
New
Taweechaisupapong et al., Khon Kaen, Thailand. In World J Microbiol Biotechnol, Feb 2016
Lactoferrin chimera (LFchimera), a hybrid peptide containing the two antimicrobial stretches of the innate immunity factor bovine lactoferrin, viz.
Comparison of lactoferrin activity in fresh and stored human milk.
New
Telang et al., Louisville, United States. In J Perinatol, Jan 2016
OBJECTIVE: Lactoferrin (Lf), the dominant protein in human milk (HM), has been shown to have anti-inflammatory and anti-microbial activity in the neonatal gut.
Polymorphisms in the promoter region of the bovine lactoferrin gene influence milk somatic cell score and milk production traits in Chinese Holstein cows.
New
Yang et al., Yangzhou, China. In Res Vet Sci, Dec 2015
Lactoferrin is an iron-binding protein found in cow's milk that plays an important role in preventing mastitis caused by intramammary infection.
Research progress in physicochemical characteristics of lactoferrin and its recombinant expression systems.
Review
New
Defu et al., Tianjin, China. In Yi Chuan, Sep 2015
Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that belongs to the transferrin family.
Antiviral activities of whey proteins.
Review
New
Xia et al., Hong Kong, Hong Kong. In Appl Microbiol Biotechnol, Sep 2015
Many milk proteins encompassing native or chemically modified casein, lactoferrin, alpha-lactalbumin, and beta-lactoglobulin demonstrated antiviral activities.
Production of human lactoferrin and lysozyme in the milk of transgenic dairy animals: past, present, and future.
Review
New
Murray et al., Davis, United States. In Transgenic Res, Aug 2015
Human milk contains high levels of antimicrobial proteins that are found in low concentrations in the milk of ruminants, including the antimicrobial proteins lactoferrin and lysozyme.
[Research progress of lactoferrin as drug carriers].
Review
New
Lü et al., In Yao Xue Xue Bao, Jun 2015
Lactoferrin (Lf) is one of the food protein belonged to the innate immune system.
A Novel Murine Anti-Lactoferrin Monoclonal Antibody Activates Human Polymorphonuclear Leukocytes through Membrane-Bound Lactoferrin and TLR4.
Gao et al., Suzhou, China. In Biomed Res Int, 2014
Soluble lactoferrin (LTF) is a versatile molecule that not only regulates the iron homeostasis, but also harbors direct microbicidal and immunomodulating abilities in mammalian body fluids.
Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology.
Review
Actor, Houston, United States. In Mediators Inflamm, 2014
Lactoferrin, an iron-binding glycoprotein found in mucosal secretions and granules of neutrophils, is just such a potential adjunct therapeutic agent.
Bovine Lactoferrin-Induced CCL1 Expression Involves Distinct Receptors in Monocyte-Derived Dendritic Cells and Their Monocyte Precursors.
Puddu et al., Roma, Italy. In Toxins (basel), 2014
Lactoferrin (LF) exhibits a wide range of immunomodulatory activities including modulation of cytokine and chemokine secretion.
Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway.
Raje et al., India. In Sci Rep, 2014
Lactoferrin is a crucial nutritionally important pleiotropic molecule and iron an essential trace metal for all life.
Lactoferrin: an alternative view of its role in human biological fluids.
Review
GeneRIF
Tsuda et al., Nagoya, Japan. In Biochem Cell Biol, 2012
The roles of lactoferrin in mucosal immunity and neutrophil function. [Review]
The human lactoferrin-derived peptide hLF1-11 exerts immunomodulatory effects by specific inhibition of myeloperoxidase activity.
GeneRIF
Nibbering et al., Leiden, Netherlands. In J Immunol, 2012
An antimicrobial peptide GRRRRSVQWCA (LF1-11), derived from human lactoferrin N-terminus, may exert its modulatory effects on human monocytes by specific inhibition of myeloperoxidase activity.
Effect of glucose on the lactoferrin's conformation and its effect on MC 3T3-E1 cell proliferation.
GeneRIF
Ren et al., Lanzhou, China. In Protein J, 2012
Glucose reduced the ability of LF to increase MC 3T3-E1 cell proliferation.
Inhibition of Epstein-Barr virus infection by lactoferrin.
GeneRIF
Li et al., Changsha, China. In J Innate Immun, 2011
These data suggest that LF may inhibit Epstein-Barr virus infection and that its downregulation could contribute to nasopharyngeal carcinoma development.
The Pepsin Hydrolysate of Bovine Lactoferrin Causes a Collapse of the Membrane Potential in Escherichia coli O157:H7.
Matthews et al., New Brunswick, United States. In Probiotics Antimicrob Proteins, 2010
In the present study, the ability of bovine lactoferrin hydrolysate (LfH) to disrupt the cytoplasmic membrane of Escherichia coli O157:H7 was investigated.
Crystal structure of human seminal diferric lactoferrin at 3.4 Angstrom resolution.
GeneRIF
Singh et al., New Delhi, India. In Indian J Biochem Biophys, 2003
structure of seminal diferric lactoferrin
Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.
Impact
Andersson et al., Stockholm, Sweden. In Lancet, 2002
Neutrophils were also tested for lactoferrin and ability to produce oxidative burst.
Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA.
Impact
Furmanski et al., New York City, United States. In Nature, 1995
Lactoferrin, an iron-binding glycoprotein found in high concentrations in human milk and other epithelial secretions and in the secondary (specific) granules of neutrophils, is thought to be responsible for primary defence against microbial infection, mainly as a result of lactoferrin sequestration of iron required for microbial growth.
Radioimmunoassay of lactoferrin in pancreatic juice as a test for pancreatic diseases.
Impact
Read et al., In Lancet, 1978
Lactoferrin, a protein present in pancreatic juice and other exocrine secretions, was measured by radioimmunoassay in pure pancreatic juice obtained by endoscopic cannulation of the pancreatic duct.
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