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Lactate dehydrogenase A

lactate dehydrogenase
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, V1a, AGE
Papers using lactate dehydrogenase antibodies
Agents Classified by the IARC Monographs, Volumes 1–102.
Fry Rebecca C. et al., In Environmental Health Perspectives, 2009
... To measure cytotoxicity, we measured the enzyme lactate dehydrogenase (LDH) within the supernatant of each sample using a coupled enzymatic assay (Clontech Laboratories, Inc., Mountain View, ...
Aptamers based electrochemical biosensor for protein detection using carbon nanotubes platforms.
Willson Richard C., In PLoS ONE, 2009
... ALT (human liver) and lactate dehydrogenase (LDH) were obtained from Lee Biosolutions, Inc ...
Timing differences of signaling response in neuron cultures activated by glutamate analogue or free radicals
Jiang Jing Hua et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2007
... The lactate dehydrogenase (LDH) kit was purchased from Biovision Research Products (Biovision, Calif, ...
IIAGlc Inhibition of glycerol kinase: a communications network tunes protein motions at the allosteric site
Nidetzky Bernd et al., In Protein Expression and Purification, 2006
... , Phosphoenolpyruvate, pyruvate kinase (PK, 986 U/mL), lactate dehydrogenase (LDH, 1230 U/mL), ATP (99% purity) and the protease inhibitor cocktail were from Sigma Aldrich (St ...
Papers on lactate dehydrogenase
Toxicological assessment of a prototype e-cigaret device and three flavor formulations: a 90-day inhalation study in rats.
Mckinney et al., Ashland, United States. In Inhal Toxicol, Feb 2016
Dose-related decreases in thymus and spleen weights, and increased BALF lactate dehydrogenase, total protein, alveolar macrophages, neutrophils and lung weights were observed.
Baseline peripheral blood biomarkers associated with clinical outcome of advanced melanoma patients treated with ipilimumab.
Weide et al., Tübingen, Germany. In Clin Cancer Res, Feb 2016
EXPERIMENTAL DESIGN: Frequencies of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs), serum lactate dehydrogenase (LDH), routine blood counts, and clinical characteristics were assessed in 209 patients.
Lowered Cisplatin Dose and No Bleomycin in the Treatment of Pediatric Germ Cell Tumors: Results of the GCT-99 Protocol From the Brazilian Germ Cell Pediatric Oncology Cooperative Group.
Zanardo de Oliveira et al., Salvador, Brazil. In J Clin Oncol, Feb 2016
In univariable and multivariable analysis, increased serum lactate dehydrogenase level and histology for a metastatic immature teratoma were prognostic of a worsened outcome.
Are compression garments effective for the recovery of exercise-induced muscle damage? A systematic review with meta-analysis.
Terrados et al., Vitoria-Gasteiz, Spain. In Physiol Behav, Feb 2016
Applying compression reduced lactate dehydrogenase (standard mean difference=-0.52, 2 studies), muscle swelling (standard mean difference=-0.73, 5 studies) and perceptual measurements (standard mean difference=-0.43, 15 studies).
Myeloma today: Disease definitions and treatment advances.
Rajkumar, Rochester, United States. In Am J Hematol, Jan 2016
A Revised International Staging System has been developed which combines markers of tumor burden (albumin, beta-2 microglobulin) with markers of aggressive disease biology (high-risk cytogenetics and elevated serum lactate dehydrogenase).
When to Treat Adults Like Children: Optimizing Therapy for Lymphoblastic Lymphoma in Young Adults.
Advani et al., Cleveland, United States. In J Clin Oncol, Jan 2016
The patient's lactate dehydrogenase concentration was 327 U/L (normal range, 118-225 U/L).
Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study.
Dombret et al., Marseille, France. In J Clin Oncol, Jan 2016
Multivariate analysis identified serum lactate dehydrogenase level and the NOTCH1/FBXW7/RAS/PTEN oncogene (a four-gene oncogenetic classifier) status but not positron emission tomography or hematopoietic stem cell transplant as independent prognostic factors for outcome in T-LL.
Routine Imaging for Diffuse Large B-Cell Lymphoma in First Complete Remission Does Not Improve Post-Treatment Survival: A Danish-Swedish Population-Based Study.
Jerkeman et al., Odense, Denmark. In J Clin Oncol, Jan 2016
Cumulative 2-year progression rate after CR was 6% (95% CI, 4 to 9) for International Prognostic Index (IPI) ≤ 2 versus 21% (95% CI, 13 to 28) for IPI > 2. Age > 60 years (hazard ratio [HR], 2.3; 95% CI, 1.6 to 3.4), elevated lactate dehydrogenase (HR, 2.3; 95% CI, 1.4 to 3.8), B symptoms (HR, 1.7; 95% CI, 1.1 to 2.5), and Eastern Cooperative Oncology Group performance status ≥ 2 (HR, 1.8; 95% CI, 1.0 to 3.0) were associated with worse post-CR survival.
Principles of Melanoma Staging.
Gershenwald et al., Houston, United States. In Cancer Treat Res, Dec 2015
Additionally, stratification of distant metastases has evolved as survival outcomes have been shown to vary based upon anatomic site of metastases and serum lactate dehydrogenase levels.
ALA Pretreatment Improves Waterlogging Tolerance of Fig Plants.
Wang et al., Nanjing, China. In Plos One, Dec 2015
Moreover, ALA pretreatment significantly increased activities of leaf superoxide dismutase (SOD) and peroxidase (POD), root vigor, and activities of root alcohol dehydrogenase (ADH), and lactate dehydrogenase (LDH), indicating ALA also significantly improves antioxidant ability and root function of fig plants under waterlogging stress.
Cardioprotective Effects of Astragalin against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart.
Wang et al., Jinan, China. In Oxid Med Cell Longev, Dec 2015
Compared with I/R group, lactate dehydrogenase (LDH) and creatine kinase (CK) activities in coronary flow decreased in astragalin pretreatment groups, whereas superoxide dismutase (SOD) activity and glutathione/glutathione disulfide (GSH/GSSG) ratio significantly increased.
Berberine Attenuates Myocardial Ischemia/Reperfusion Injury by Reducing Oxidative Stress and Inflammation Response: Role of Silent Information Regulator 1.
Yu et al., Xi'an, China. In Oxid Med Cell Longev, Dec 2015
BBR conferred cardioprotective effects by improving postischemic cardiac function, decreasing infarct size, reducing apoptotic index, diminishing serum creatine kinase and lactate dehydrogenase levels, upregulating SIRT1, Bcl-2 expressions, and downregulating Bax and caspase-3 expressions.
Adult metastatic yolk sac tumor descending from an intra-abdominal testis: A case report and review of the literature.
Yang et al., Changsha, China. In Oncol Lett, Dec 2015
Elevated levels of specific serum marker (α-fetoprotein, lactate dehydrogenase and human chorionic gonadotropin) did not indicate potential testicular germ cell types prior to surgery and pathological examination.
Cutaneous Lymphoma International Consortium Study of Outcome in Advanced Stages of Mycosis Fungoides and Sézary Syndrome: Effect of Specific Prognostic Markers on Survival and Development of a Prognostic Model.
Kim et al., Birmingham, United Kingdom. In J Clin Oncol, Dec 2015
PATIENTS AND METHODS: Literature review identified the following 10 candidate markers: stage, age, sex, cutaneous histologic features of folliculotropism, CD30 positivity, proliferation index, large-cell transformation, WBC/lymphocyte count, serum lactate dehydrogenase, and identical T-cell clone in blood and skin.
Non-Hodgkin lymphoma diagnosed by a percutaneous trans-hepatic needle biopsy of portal vein tumor emboli.
Takahashi et al., In Rinsho Ketsueki, 2014
We suspected non-Hodgkin lymphoma (NHL) based on the high values of serum soluble interleukin-2 receptor and lactate dehydrogenase.
Inhibition of LDH-A by lentivirus-mediated small interfering RNA suppresses intestinal-type gastric cancer tumorigenicity through the downregulation of Oct4.
Qin et al., Shanghai, China. In Cancer Lett, 2012
We demonstrate that LDH-A reduction can suppress the tumorigenicity of intestinal-type gastric cancer (ITGC) cells by downregulating Oct4 both in vitro and in vivo.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells.
Chen et al., Atlanta, United States. In Mol Cell Biol, 2011
LDH-A is tyrosine phosphorylated and activated by FGFR1 in cancer cells.
Physical therapy-induced rhabdomyolysis and acute kidney injury associated with reduced activity of muscle lactate dehydrogenase A.
Qian et al., Boston, United States. In Arthritis Care Res (hoboken), 2011
Case Report: describe an elderly patient with physical therapy-induced rhabdomyolysis complicated by acute kidney injury associated with reduced skeletal muscle LDH-A activity.
Towards improved prognostic scores predicting survival in patients with brain metastases: a pilot study of serum lactate dehydrogenase levels.
Norum et al., Bodø, Norway. In Scientificworldjournal, 2011
Data suggest that serum lactate dehydrogenase (LDH) kinetics might reflect disease behaviour in extracranial metastatic and primary sites without need for comprehensive imaging studies and is a quite inexpensive diagnostic test.
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