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Mitochondrial ribosomal protein L13

L13, A52, L13a, Dmca1A
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GAPDH, CAN, ACID, Actin, V1a
Papers on L13
Normalization of Reverse Phase Protein Microarray Data: Choosing the Best Normalization Analyte.
New
Chiechi, Indianapolis, United States. In Methods Mol Biol, Dec 2015
Using geNorm and NormFinder algorithms, we screened seven normalization analytes (ssDNA, glyceraldehyde 3-phosphate dehydrogenase (GAPDH), α/β-tubulin, mitochondrial ribosomal protein L11 (MRPL11), ribosomal protein L13a (RPL13a), β-actin, and total protein) across different sample sets, including cell lines, blood contaminated tissues, and tissues subjected to laser capture microdissection (LCM), to identify the analyte with the lowest variability.
Laparoscopic Adrenalectomy for Ovarian Metastasis and Underlying Horse Shoe Kidney.
New
Syed et al., Karāchi, Pakistan. In J Coll Physicians Surg Pak, Oct 2015
A52 years female with high grade serous carcinoma ovary, horse shoe kidney and previous history of two laparotomies for primary malignancy developed adrenal metastasis 3 years after diagnosis of the primary lesion.
L13a-dependent translational control in macrophages limits the pathogenesis of colitis.
New
Mazumder et al., Cleveland, United States. In Cell Mol Immunol, Aug 2015
Taken together, these results reveal an essential role for L13a in the endogenous protection against UC and demonstrate the potential for new therapeutic opportunities through the deliberate promotion of this mechanism.Cellular & Molecular Immunology advance online publication, 13 July 2015; doi:10.1038/cmi.2015.53.
Selection of suitable reference genes for expression analysis in human glioma using RT-qPCR.
New
Walter et al., Jena, Germany. In J Neurooncol, May 2015
This study aimed at testing a panel of nine reference genes [beta-2-microglobulin, cytochrome c-1 (CYC1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), hydroxymethylbilane synthase, hypoxanthine guanine phosphoribosyl transferase 1, ribosomal protein L13a (RPL13A), succinate dehydrogenase, TATA-box binding protein and 14-3-3 protein zeta] to identify and validate the most suitable reference genes for expression studies in human glioma of different grades (World Health Organization grades II-IV).
RPL13A as a reference gene for normalizing mRNA transcription of ovarian cancer cells with paclitaxel and 10-hydroxycamptothecin treatments.
New
Fu et al., Harbin, China. In Mol Med Report, Apr 2015
A total of 9 genes were demonstrated to exhibit high transcriptional stability and one of these genes, ribosomal protein L13a (RPL13A), was identified to exhibit high transcriptional stability in every group.
Identification of a gamma interferon-activated inhibitor of translation-like RNA motif at the 3' end of the transmissible gastroenteritis coronavirus genome modulating innate immune response.
Almazán et al., Madrid, Spain. In Mbio, 2014
The GAIT element is involved in the translation silencing of these mRNAs through its interaction with the GAIT complex (EPRS, heterogeneous nuclear ribonucleoprotein Q, ribosomal protein L13a, and glyceraldehyde 3-phosphate dehydrogenase) to favor the resolution of inflammation.
Identification and evaluation of suitable reference genes for gene expression studies in the whitefly Bemisia tabaci (Asia I) by reverse transcription quantitative realtime PCR.
Seal et al., Chatham, United Kingdom. In J Insect Sci, 2013
We identified orthologs of commonly used reference genes (actin (ACT), cyclophilin 1 (CYP1), elongation factor 1α (EF1A), glyceraldehyde 3-phosphate dehydrogenase (GAPDH), ribosomal protein L13a (RPL13A), and α-tubulin (TUB1A)), measured the levels of their transcripts by RT-qPCR during development and in response to thermal stress, and evaluated their suitability as endogenous controls using geNorm, BestKeeper, and NormFinder programs.
Transsynaptic control of presynaptic Ca²⁺ influx achieves homeostatic potentiation of neurotransmitter release.
GeneRIF
Davis et al., San Francisco, United States. In Curr Biol, 2012
Homeostatic increase in Ca(2+) influx and release is blocked by a point mutation in the presynaptic CaV2.1 channel.
Small nucleolar RNAs U32a, U33, and U35a are critical mediators of metabolic stress.
Impact
Schaffer et al., Saint Louis, United States. In Cell Metab, 2011
We show that loss of three box C/D small nucleolar RNAs (snoRNAs) encoded in the ribosomal protein L13a (rpL13a) locus is sufficient to confer resistance to lipotoxic and oxidative stress in vitro and prevents the propagation of oxidative stress in vivo.
The GAIT system: a gatekeeper of inflammatory gene expression.
Review
Fox et al., Cleveland, United States. In Trends Biochem Sci, 2009
In myeloid cells, interferon (IFN)-gamma induces formation of the heterotetrameric, IFN-gamma-activated inhibitor of translation (GAIT) complex comprising glutamyl-prolyl tRNA synthetase (EPRS), NS1-associated protein 1 (NSAP1), ribosomal protein L13a and glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
Functional characterization of ribosomal protein L15 from Saccharomyces cerevisiae.
GeneRIF
Nygård et al., Huddinge, Sweden. In Curr Genet, 2009
The function of YrpL15A is highly resilient to single and multiple amino acid substitutions. In addition, minor deletions from both the N- and C-terminal ends of YrpL15A has no effect on protein function
RNF135 mutations are not present in patients with Sotos syndrome-like features.
GeneRIF
Losekoot et al., Leiden, Netherlands. In Am J Med Genet A, 2009
RNF135 mutations are not present in patients with Sotos syndrome-like features.
Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection.
GeneRIF
Seya et al., Sapporo, Japan. In J Biol Chem, 2009
identify an alternative factor, Riplet/RNF135, that promotes RIG-I activation independent of TRIM25
REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I.
GeneRIF
Chen et al., Beijing, China. In Plos One, 2008
REUL is an E3 ubiquitin ligase of RIG-I and specifically stimulates RIG-I-mediated innate antiviral activity
Extending the S-FFT direct-methods algorithm to density functions with positive and negative peaks. XIV.
Impact
Frontera et al., Barcelona, Spain. In Acta Crystallogr A, 2008
A52, 634-639].
Reduction in infectivity of endogenous transmissible spongiform encephalopathies present in blood by adsorption to selective affinity resins.
Impact
Rohwer et al., Baltimore, United States. In Lancet, 2007
In our study, affinity resin L13, which reduces brain-derived infectivity spiked into human red blood cell concentrate by around 4 log(10)ID(50), and its equivalent, L13A, produced on a manufacturing scale, were assessed for their ability to remove TSE infectivity endogenously present in blood.
On the calculation of the electrostatic potential, electric field and electric field gradient from the aspherical pseudoatom model.
Impact
Farrugia et al., Buffalo, United States. In Acta Crystallogr A, 2006
(1996), A52, 748-756] but slightly smaller than the generally accepted value of 0.16 +/- 5% x 10(-28) m(2) obtained from combined theoretical/spectroscopic studies [Dufek, Blaha & Schwarz (1995).
Ribosomal proteins in cell proliferation and apoptosis.
Review
Ioannou et al., New York City, United States. In Int Rev Immunol, 1998
Specifically, expression of human ribosomal protein L13a has been shown to induce apoptosis, presumably by arresting cell growth in the G2/M phase of the cell cycle.
[Isotypes and subtypes of anti-SS-A and/or SS-B antibodies in different subgroups of Sjögren's syndrome].
Review
Ichikawa et al., Funaishikawa, Japan. In Nihon Rinsho, 1995
Profiles of anti-SS-A/SS-B antibodies, including their isotypes and subtypes, in patients with primary Sjögren's syndrome (SS) were similar to those in SS patients with systemic lupus erythematosus (SLE), except for anti-SS-A52-Kd/60-Kd antibody profiles.
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