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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Selectin L

L-selectin, CD62L
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: CD4, CD8, CAN, CD44, CD11b
Papers using L-selectin antibodies
CD4 T cells: fates, functions, and faults
Supplier
Kawashima Hiroto et al., In The Journal of Experimental Medicine, 2007
... -sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules ...
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm
Supplier
Nohé Boris et al., In Biologics : Targets & Therapy, 2003
... , fluorescein conjugates, Caltag, San Francisco, CA), CD15 (IgM, phycoerythrin-conjugate), CD45, CD62L (IgG1, fluorescein-conjugates, Becton Dickinson, San Jose, CA), Lewis ...
The use of carboxyfluorescein diacetate succinimidyl ester to determine the site, duration and cell type responsible for antigen presentation in vivo.
Supplier
Zimmer Jacques, In PLoS ONE, 1998
... T-cells were further selected for CD62L expression using magnetic beads (Miltenyi Biotec).
Papers on L-selectin
γδ T Cells Protect the Liver and Lungs of Mice from Autoimmunity Induced by Scurfy Lymphocytes.
New
Shevach et al., Bethesda, United States. In J Immunol, Feb 2016
γδ T cells in the TCRα(-/-) recipients of scurfy cells markedly expanded and expressed a highly activated (CD62L(lo)CD44(hi)) phenotype.
Nasal vaccination stimulates CD8(+) T cells for potent protection against mucosal Brucella melitensis challenge.
New
Pascual et al., Gainesville, United States. In Immunol Cell Biol, Feb 2016
Evaluation of pulmonary and splenic CD8(+) T cells from mice vaccinated with ΔznuA B. melitensis revealed that these expressed an activated effector memory (CD44(hi)CD62L(lo)CCR7(lo)) T cells producing elevated levels of IFN-γ, TNF-α, perforin, and granzyme B. To assess the relative importance of these increased numbers of CD8(+) T cells, CD8(-/-) mice were challenged with virulent B. melitensis, and they showed markedly increased bacterial loads in organs in contrast to similarly challenged CD4(-/-) mice.
Characterization of age-associated exhausted CD8(+) T cells defined by increased expression of Tim-3 and PD-1.
New
Kang et al., Seoul, South Korea. In Aging Cell, Feb 2016
Tim-3-expressing cells also produced PD-1, but Tim-3(+) PD-1(+) CD8(+) T cells had a distinct phenotype that included the expression of CD44 and CD62L, from Tim-3(-) PD-1(+) cells.
Trypanosoma cruzi Experimental Infection Impacts on the Thymic Regulatory T Cell Compartment.
New
Pérez et al., Rosario, Argentina. In Plos Negl Trop Dis, Jan 2016
Moreover, tTregs enhance after the infection the expression of signature markers (CD25, CD62L and GITR) and they also display alterations in the expression of migration-associated molecules (α chains of VLAs and chemokine receptors) such as functional fibronectin-driven migratory disturbance.
CD62L is not a reliable biomarker for predicting PML risk in natalizumab-treated R-MS patients.
New
Cahir-McFarland et al., Cambridge, United States. In Neurology, Jan 2016
OBJECTIVE: To assess if the percentage of CD3(+)CD4(+)CD62L(+) cells in cryopreserved peripheral blood mononuclear cells (PBMCs) (here termed %CD62L) can predict risk of developing progressive multifocal leukoencephalopathy (PML) and better inform the physician for benefit-risk assessment of natalizumab treatment decisions in a global setting.
Transcription factor Foxo1 is a negative regulator of natural killer cell maturation and function.
New
Impact
Yu et al., Columbus, United States. In Immunity, Apr 2015
Foxo1 promoted NK cell homing to lymph nodes by upregulating CD62L expression and inhibited late-stage maturation and effector functions by repressing Tbx21 expression.
Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.
Review
Barron-Casella et al., Baltimore, United States. In Proteomics Clin Appl, 2014
Included articles focused on growth factors (platelet-derived growth factor), intra and extracellular brain proteins (glial fibrillary acidic protein, brain-derived neurotrophic factor), and inflammatory and coagulation markers (interleukin-1β, l-selectin, thrombospondin-1, erythrocyte, and platelet-derived microparticles).
CD8(+)CD122(+) T-Cells: A Newly Emerging Regulator with Central Memory Cell Phenotypes.
Review
Dai et al., Guangzhou, China. In Front Immunol, 2014
However, mounting evidence has demonstrated that murine CD8(+)CD122(+) T-cells exhibit a central memory phenotype (CD44(high)CD62L(high)), regulate T cell homeostasis, and act as regulatory T-cells (Treg) by suppressing both autoimmune and alloimmune responses.
Memory T cells officially join the stem cell club.
Impact
Gattinoni, Bethesda, United States. In Immunity, 2014
(2014) demonstrate self-renewal and multipotency of a single CD62L(+) memory T cell across serial adoptive transfers and infection-driven re-expansions, providing evidence of true stemness within the T cell memory compartment.
Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells.
Impact
Busch et al., München, Germany. In Immunity, 2014
These observations establish that adult tissue stem cells reside within the CD62L(+) Tcm cell compartment and highlight the promising therapeutic potential of this immune cell subset.
Immunological Markers for PML Prediction in MS Patients Treated with Natalizumab.
Review
Stankoff et al., Paris, France. In Front Immunol, 2013
Other immunological biomarkers such as leukocyte cell membrane markers (CD49d, CD11a, and CD62L), detection of circulating JCV-specific activated T effector memory cells (TEM) or genetic screening have been proposed.
CD20+ mycosis fungoides: a report of three cases and review of the literature.
Review
Magro et al., Farmington, United States. In Am J Dermatopathol, 2013
The classic phenotypic profile is one defined by CD4+ T cells showing a reduction in the expression of CD7 and CD62L.
Rhythmic modulation of the hematopoietic niche through neutrophil clearance.
Impact
Hidalgo et al., Madrid, Spain. In Cell, 2013
We identify a population of CD62L(LO) CXCR4(HI) neutrophils that have "aged" in the circulation and are eliminated at the end of the resting period in mice.
Lymphoid priming in human bone marrow begins before expression of CD10 with upregulation of L-selectin.
Impact
Crooks et al., Los Angeles, United States. In Nat Immunol, 2012
We identified this subset by high expression of the homing molecule L-selectin (CD62L).
Signaling through L-selectin mediates enhanced chemotaxis of lymphocyte subsets to secondary lymphoid tissue chemokine.
GeneRIF
Steeber et al., Milwaukee, United States. In J Immunol, 2012
Signaling induced by ligation of L-selectin using mAb or endothelial cell-expressed ligand significantly enhanced the chemotaxis of murine T cells and B cells to SLC but not to other homeostatic chemokines.
Mucin 16 is a functional selectin ligand on pancreatic cancer cells.
GeneRIF
Konstantopoulos et al., Baltimore, United States. In Faseb J, 2012
Data indicate that MUC16 immunopurified from pancreatic cancer cells efficiently binds E- and L- but not P-selectin.
γδ T cell homing to skin and migration to skin-draining lymph nodes is CCR7 independent.
GeneRIF
Koets et al., Utrecht, Netherlands. In J Immunol, 2012
gammadelta T cells, the main recirculating subset in both afferent and efferent lymph, have high levels of CD62L cell surface expression.
Relationship between plasma aldosterone concentration and soluble cellular adhesion molecules in patients referred to coronary angiography.
GeneRIF
März et al., Graz, Austria. In Exp Clin Endocrinol Diabetes, 2011
Data suggest that up-regulation of plasma selectins (selectin E, selectin L, and selectin P) may represent novel mechanism of aldosterone-mediated development/progression of atherosclerosis.
Investigation of P213S SELL gene polymorphism in type 2 diabetes mellitus and related end stage renal disease. A case-control study.
GeneRIF
Ion et al., Bucureşti, Romania. In Rom J Morphol Embryol, 2010
No statistically significant results were found in order to sustain the hypothesis of association between SELL gene P213S polymorphism, type 2 diabetes mellitus and end stage renal disease.
[Selectins as adhesion molecules and potential therapeutic target].
Review
Marrakchi et al., Tunisia. In Arch Inst Pasteur Tunis, 2010
There are three types of selectin: the L-selectin (CD62L), which is constitutively expressed by most leukocyte populations, the P-selectin (CD62P) is found on activated platelets and endothelial cells, and the E-selectin (CD62E) expressed by activated endothelial cells.
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