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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

V-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived

L-myc, MYCL1, MYCL
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Top mentioned proteins: c-Myc, N-myc, CAN, HAD, p53
Papers on L-myc
The Cables1 gene in glucocorticoid regulation of pituitary corticotrope growth and Cushing disease.
Drouin et al., Montréal, Canada. In J Clin Endocrinol Metab, Jan 2016
Two Myc genes (L-Myc, N-Myc) and E2F2 are repressed by Gc whereas genes for the negative regulators of cell cycle Gadd45β, Gadd45γ and Cables1 are actived by Gc.
Soluble expression and stability enhancement of transcription factors using 30Kc19 cell-penetrating protein.
Park et al., Seoul, South Korea. In Appl Microbiol Biotechnol, Jan 2016
Transcription factors fused with 30Kc19 (Oct4-30Kc19, Sox2-30Kc19, c-Myc-30Kc19, L-Myc-30Kc19, and Klf4-30Kc19) were produced as recombinant proteins.
Transduction of Oct6 or Oct9 gene concomitant with Myc family gene induced osteoblast-like phenotypic conversion in normal human fibroblasts.
Kubo et al., Kyoto, Japan. In Biochem Biophys Res Commun, Dec 2015
Transduction of Runx2 (R), Osterix (X), Oct3/4 (O) and L-myc (L) genes followed by culturing under osteogenic conditions induced normal human fibroblasts to express osteoblast-specific genes and produce calcified bone matrix both in vitro and in vivo Intriguingly, a combination of only two factors, Oct3/4 and L-myc, significantly induced osteoblast-like phenotype in fibroblasts, but the mechanisms underlying the direct conversion remains to be unveiled.
Comparison of the Efficiency of Viral Transduction and Episomal Transfection in Human Fibroblast Reprogramming.
Yarygin et al., Moscow, Russia. In Bull Exp Biol Med, Nov 2015
Episomal transfection with vectors containing oriP/EBNA-1 sequence for delivery of reprogramming genes Oct4, Sox2, Klf4, L-Myc, and Lin28 proved to be more effective than viral transduction with Sendai virus-based vector: ~200 and 8 colonies per 10(5) cells were found on day 21 of culturing, respectively.
Hepatocellular Carcinoma in Noncirrhotic Liver with Glycogenotic Foci: Basic Science Meets Genomic Medicine.
Kato et al., New York City, United States. In Semin Liver Dis, Nov 2015
Precision genomic analysis of this tumor disclosed five alterations with amplifications of genes CCNE1, FGF3 and FGF4, MYCL1, and ARID1A.
Generation and periodontal differentiation of human gingival fibroblasts-derived integration-free induced pluripotent stem cells.
Luan et al., Beijing, China. In Biochem Biophys Res Commun, Nov 2015
Here, we successfully generated iPSCs from readily accessible human gingival fibroblasts (hGFs) through an integration-free and feeder-free approach via delivery of reprogramming factors of Oct4, Sox2, Klf4, L-myc, Lin28 and TP53 shRNA with episomal plasmid vectors.
Impact of MYC in regulation of tumor cell metabolism.
Henriksson et al., Stockholm, Sweden. In Biochim Biophys Acta, May 2015
The MYC proto-oncoproteins including c-MYC, MYCN and MYCL exert their functions as heterodimers with MAX, which in turn binds to E-box sequences at target promoters to regulate gene expression.
Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis.
Eisenman et al., Hutchinson, United States. In Biochim Biophys Acta, May 2015
The transcription factor MYC and its related family members MYCN and MYCL have been implicated in the etiology of a wide spectrum of human cancers.
L-Myc expression by dendritic cells is required for optimal T-cell priming.
Murphy et al., Saint Louis, United States. In Nature, 2014
A third paralogue, Mycl1, is dispensable for normal embryonic development but its biological function has remained unclear.
Role of MYC in Medulloblastoma.
Robinson et al., Memphis, United States. In Cold Spring Harb Perspect Med, 2013
Since its discovery as an oncogene carried by the avian acute leukemia virus MC29 in myelocytomatosis (Roussel et al. 1979) and its cloning (Vennstrom et al. 1982), c-MYC (MYC), as well as its paralogs MYCN and MYCL1, has been shown to play essential roles in cycling progenitor cells born from proliferating zones during embryonic development, and in all proliferating cells after birth.
Myc in stem cell behaviour: insights from Drosophila.
Hime et al., Melbourne, Australia. In Adv Exp Med Biol, 2012
Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively.
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
Seshagiri et al., Baltimore, United States. In Nat Genet, 2012
RNA sequencing identified multiple fusion transcripts and a recurrent RLF-MYCL1 fusion.
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.
Accili et al., New York City, United States. In Cell, 2012
Dedifferentiated β cells reverted to progenitor-like cells expressing Neurogenin3, Oct4, Nanog, and L-Myc.
Genetic variation in an miRNA-1827 binding site in MYCL1 alters susceptibility to small-cell lung cancer.
Lin et al., Beijing, China. In Cancer Res, 2011
MYCL1 is the target of hsa-miR-1827. A rs3134615 G>T SNP in the 3'-UTR altered regulation of MYCL1 expression. This SNP was associated with increased susceptibility to SCLC, possibly resulting from attenuated interaction with the miRNA hsa-miR-1827.
A more efficient method to generate integration-free human iPS cells.
Yamanaka et al., Kyoto, Japan. In Nat Methods, 2011
We report a simple method, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors.
Association of a MYCL1 single nucleotide polymorphism, rs3134613, with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer in a southeast Chinese population.
Lin et al., Fuzhou, China. In Dna Cell Biol, 2010
The results demonstrate that MYCL1 rs3134613 is associated with susceptibility to diffuse-type gastric cancer and with differentiation of gastric cancer.
Promotion of direct reprogramming by transformation-deficient Myc.
Yamanaka et al., Kyoto, Japan. In Proc Natl Acad Sci U S A, 2010
L-Myc, as well as c-Myc mutants (W136E and dN2), all of which have little transformation activity, promoted human iPSC generation more efficiently and specifically compared with WT c-Myc.
Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc.
Nghiem et al., Seattle, United States. In J Invest Dermatol, 2009
L-Myc may have a role in Merkel cell carcinoma pathogenesis
L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers.
Isbir et al., İstanbul, Turkey. In Arch Otolaryngol Head Neck Surg, 2008
The L-myc gene polymorphism may help detect and prevent HNNMSC and LLC in susceptible individuals. It may also contribute to estimation of tumor behavior in patients with HNNMSC.
L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer.
Minna et al., In Nature, 1985
Here we describe a third myc-related gene (L-myc) cloned from SCLC DNA with homology to a small region of both the c-myc and N-myc genes.
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