Impact of MYC in regulation of tumor cell metabolism.
Stockholm, Sweden. In Biochim Biophys Acta, May 2015
The MYC proto-oncoproteins including c-MYC, MYCN and MYCL exert their functions as heterodimers with MAX, which in turn binds to E-box sequences at target promoters to regulate gene expression.
Role of MYC in Medulloblastoma.
Memphis, United States. In Cold Spring Harb Perspect Med, 2013
Since its discovery as an oncogene carried by the avian acute leukemia virus MC29 in myelocytomatosis (Roussel et al. 1979) and its cloning (Vennstrom et al. 1982), c-MYC (MYC), as well as its paralogs MYCN and MYCL1, has been shown to play essential roles in cycling progenitor cells born from proliferating zones during embryonic development, and in all proliferating cells after birth.
Myc in stem cell behaviour: insights from Drosophila.
Melbourne, Australia. In Adv Exp Med Biol, 2012
Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively.