GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Aug 2016.
Ficolin
L-ficolin, ficolin, H-ficolin, Ficolin-2, Ficolin-3, Hakata antigen, FCN2
The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from
NCBI)
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Top mentioned proteins:
MBL, HAD, CAN, ACID, V1a
Papers on
L-ficolin
Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.
New
Albuquerque, United States. In Dev Comp Immunol, Mar 2016
In addition to stimulating genes involved in cell proliferation, the injected substances, especially LPS, also induced expression of a number of immune-related genes including arginase, peptidoglycan recognition protein short form, tumor necrosis factor receptor, ficolin, calmodulin, bacterial permeability increasing proteins and E3 ubiquitin-protein ligase.
Ficolin Gene Polymorphisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis.
New
Recife, Brazil. In Ann Hum Genet, Jan 2016
Since genetic association studies with ficolin genes in SLE and RA have not yet been conducted in a Brazilian population, the aim of this study was to determine whether polymorphisms of ficolin-1(FCN1) and ficolin-2 (FCN2) genes are associated with SLE and RA susceptibility as well as disease manifestation.
Association of lectin pathway proteins with intra-abdominal Candida infection in high-risk surgical intensive-care unit patients. A prospective cohort study within the fungal infection network of Switzerland.
New
Basel, Switzerland. In J Infect, Jan 2016
Neither serum levels of MBL, ficolin-1, -2, -3, MASP-2 or collectin liver 1 nor MBL2 genotypes were associated with a CCI ≥0.4.
Can ficolin-2 (L-ficolin) insufficiency be established by a single serum protein measurement?
New
Łódź, Poland. In Int J Immunogenet, Dec 2015
Serum ficolin-2 was measured in multiple (2-27) samples from 68 paediatric sepsis patients.
Effects of Sequence Variations in Innate Immune Response Genes on Infectious Outcome in Trauma Patients: A Comprehensive Review.
Review
New
Rotterdam, Netherlands. In Shock, Nov 2015
The following genes have been studied in populations of trauma patients: CD14, HMGB1, IFNG, IL1A, IL1B, IL1RN, IL4, IL6, IL8, IL10, IL17F, IL18, MBL2, MASP2, FCN2, TLR1, TLR2, TLR4, TLR9, TNF, LTA, GR, MYLK, NLRP3, PRDX6, RAGE, HSPA1B, HSPA1L, HSP90, SERPINE1, IRAK1, IRAK3, VEGFA, LY96, ANGPT2, LBP, MicroRNA, and mtDNA.
Host lung immunity is severely compromised during tropical pulmonary eosinophilia: role of lung eosinophils and macrophages.
New
Lucknow, India. In J Leukoc Biol, Nov 2015
Alveolar macrophages from tropical pulmonary eosinophilia mice displayed decreased phagocytosis, attenuated nitric oxide production, and reduced T-cell proliferation capacity, and FACS-sorted lung eosinophils from tropical pulmonary eosinophilia mice upregulated transcript levels of ficolin A and anti-apoptotic gene Bcl2, but proapoptotic genes Bim and Bax were downregulated.
Fibrinogen-Related Proteins in Tissue Repair: How a Unique Domain with a Common Structure Controls Diverse Aspects of Wound Healing.
Review
New
Oxford, United Kingdom. In Adv Wound Care (new Rochelle), Jun 2015
This group includes the eponymous fibrinogen as well as the tenascin, angiopoietin, and ficolin families.
Association of the FCN2 Gene Single Nucleotide Polymorphisms with Susceptibility to Pulmonary Tuberculosis.
Hangzhou, China. In Plos One, 2014
Ficolin-2 (FCN2) is an innate immune pattern recognition molecule that can activate the complement pathway, opsonophagocytosis, and elimination of the pathogens.
New insights into the role of ficolins in the lectin pathway of innate immunity.
Review
Fukushima, Japan. In Int Rev Cell Mol Biol, 2014
Ficolin is a soluble recognition molecule, which senses pathogen-associated molecular patterns on microbes and aberrant sugar structures on self-cells.
Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis.
Hangzhou, China. In Sci Rep, 2014
We validated albumin (ALB), Rho GDP-dissociation inhibitor 2 (ARHGDIB), complement 3 (C3), ficolin-2 (FCN2), and apolipoprotein (a) (LPA) using the enzyme-linked immunosorbent assay (ELISA) method.
Low serum ficolin-3 levels are associated with severity and poor outcome in traumatic brain injury.
Hangzhou, China. In J Neuroinflammation, 2014
Lower serum ficolin-3 levels have been demonstrated to be highly associated with unfavorable outcome after ischemic stroke.
Lessons learned from mice deficient in lectin complement pathway molecules.
Review
Copenhagen, Denmark. In Mol Immunol, 2014
This leads to activation of MBL/ficolin/collectin-11 associated serine proteases (MASPs), which in turn activate downstream complement components, ultimately leading to elimination of the pathogen.
Salivary proteins of plant-feeding hemipteroids - implication in phytophagy.
Review
Orange, Australia. In Bull Entomol Res, 2014
Salivary enzymes such as M1-zinc metalloprotease and CLIP-domain serine protease as in Acyrthosiphon pisum (Aphididae), and non-enzymatic proteins such as apolipophorin, ficolin-3-like protein and 'lava-lamp' protein as in Diuraphis noxia (Aphididae) have the capacity to alter host-plant-defence mechanisms.
The functional polymorphism Ala258Ser in the innate receptor gene ficolin-2 in the donor predicts improved renal transplant outcome.
GeneRIF
Leiden, Netherlands. In Transplantation, 2012
Ficolin-2 Ala258Ser polymorphism in the donor independently predicts improved graft outcome.
Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.
GeneRIF
Boston, United States. In J Immunol, 2012
H-ficolin has antiviral activity against influenza A virus (IAV). H-ficolin also fixes complement to a surface coated with IAV.
Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis.
GeneRIF
Tübingen, Germany. In J Infect Dis, 2012
These findings demonstrate that FCN2 promoter variants (-986G>A and -4A>G) influence ficolin-2 serum levels and susceptibility to schistosomiasis.
Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia.
GeneRIF
Budapest, Hungary. In Clin Exp Immunol, 2012
The purpose of this study was to determine whether circulating levels of ficolin-2 and ficolin-3 are altered in normal pregnancy and pre-eclampsia.
Mouse ficolin B has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway.
GeneRIF
Fukushima, Japan. In J Biomed Biotechnol, 2011
Results show that ficolin B in mouse bone marrow is an oligomeric protein. Ficolin B contained very low, but detectable, amounts of MASP-2 and sMAP and showed detectable C4-deposition activity on immobilized N-acetylglucosamine.
Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency.
Impact
Copenhagen, Denmark. In N Engl J Med, 2009
Ficolin-3, encoded by the FCN3 gene and expressed in the lung and liver, is a recognition molecule in the lectin pathway of the complement system.
Collections and ficolins: humoral lectins of the innate immune defense.
Review
Impact
Denmark. In Annu Rev Immunol, 2002
The human collectins, mannan-binding lectin (MBL) and surfactant protein A and D (SP-A and SP-D), are oligomeric proteins composed of carbohydrate-recognition domains (CRDs) attached to collagenous regions and are thus structurally similar to the ficolins, L-ficolin, M-ficolin, and H-ficolin.
