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Potassium voltage gated channel, Shaw-related subfamily, member 1

Kv1.4, Shaw, Kv4, Kv3.1
voltage-gated K+ channel; responsible for potassium permeability in excitable membranes [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: CAN, ACID, Kv2.1, FasT, HAD
Papers using Kv1.4 antibodies
Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway
Burgoyne Robert D. et al., In The Journal of Cell Biology, 1991
... The pcDNA3-Kv4.2 construct was made by insertion of the human Kv4.2 sequence (NM_012281) amplified from the AB1701_A07 plasmid (Origene Technologies, Inc.) by PCR, ...
Molecular Cloning: A Laboratory Manual.
Chammas Roger, In PLoS ONE, 1991
... In brief, each of the respective Kv3.1 molecules were removed from their respective Baculovirus expression vectors by EcoRI (New England BioLabs, Ipswich, MA, USA) digestion ...
Papers on Kv1.4
Rebreather Unit to Prolong Underwater Survival Time.
Roiz de Sa et al., Gosport, United Kingdom. In Aerosp Med Hum Perform, Dec 2015
House CM, Shaw AM, Roiz de Sa DG.
The Tau-Induced Reduction of mRNA Levels of Kv Channels in Human Neuroblastoma SK-N-SH Cells.
Li et al., Wuhan, China. In J Mol Neurosci, Dec 2015
In this report, transfection of tau plasmids into human neuroblastoma SK-N-SH cells caused a significant reduction in the messenger RNA (mRNA) levels of several Kv channels, including Kv2.1, Kv3.1, Kv5.1, Kv9.2, and KCNH4.
Post-transcriptional regulation of connexins.
Aasen et al., Barcelona, Spain. In Biochem Soc Trans, Jun 2015
9, 52; Smyth and Shaw (2013) Cell Rep. 5, 611-618; Salat-Canela et al. (2014) Cell Commun.
Effects of fluoxetine on protein expression of potassium ion channels in the brain of chronic mild stress rats.
Wang et al., Beijing, China. In Acta Pharm Sin B, 2015
However, the expression of Kv3.1 and Kv4.2 channels was considerably decreased in hippocampus after CMS, and was not affected by fluoxetine.
A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.
Lehesjoki et al., Helsinki, Finland. In Nat Genet, 2015
KCNC1 encodes KV3.1, a subunit of the KV3 voltage-gated potassium ion channels, which are major determinants of high-frequency neuronal firing.
Kv3.1 uses a timely resurgent K(+) current to secure action potential repolarization.
Bezanilla et al., Chicago, United States. In Nat Commun, 2014
High-frequency action potential (AP) transmission is essential for rapid information processing in the central nervous system.
Sampling Assessment for Molecular Simulations Using Conformational Entropy Calculations.
Díaz et al., Oviedo, Spain. In J Chem Theory Comput, 2014
The utility of Sconform in sampling assessment is illustrated by carrying out test calculations on configurations produced by two extended molecular dynamics simulations, namely, a 2.0 μs trajectory of a highly flexible 17-residue peptide and the trajectory data set of the 1.0 ms bovine pancreatic trypsin inhibitor simulation provided by the D. E. Shaw research group.
Celecoxib and ion channels: a story of unexpected discoveries.
Singh et al., Oulu, Finland. In Eur J Pharmacol, 2014
In experimental systems varying from Drosophila to primary mammalian and human cell lines, celecoxib inhibits many voltage-activated Na(+), Ca(2+), and K(+) channels, including NaV1.5, L- and T-type Ca(2+) channels, KV1.5, KV2.1, KV4.3, KV7.1, KV11.1 (hERG), while stimulating other K(+) channels-KV7.2-5
Adrenergic regulation of cardiac ionic channels: role of membrane microdomains in the regulation of kv4 channels.
Casis et al., Vitoria-Gasteiz, Spain. In Biochim Biophys Acta, 2014
Under these circumstances, α1-adrenergic receptors activate intracellular signaling pathways that finally phosphorylate the caveolae-located subpopulation of Kv4 channels and reduce the transient outward K(+) current (Ito) amplitude.
Mercury toxicity and neurodegenerative effects.
Genchi et al., Bari, Italy. In Rev Environ Contam Toxicol, 2013
In conclusion, depletion of GSH,breakage of mitochondria, increased lipid peroxidation, and oxidation of proteins and DNA in the brain, induced by mercury and his salts, appear to be important factors in conditions such as ALS and AD (Bains and Shaw 1997; Nicole eta!. 1998;Spencer eta!. 1998; Alberti et a!.
Potassium channels in Drosophila: historical breakthroughs, significance, and perspectives.
Singh et al., Buffalo, United States. In J Neurogenet, 2012
Drosophila has also helped in discovering other K(+) channels, such as Shab, Shaw, Shal, Eag, Sei, Elk, and also Slo, a Ca(2+) - and voltage-dependent K(+) channel.
I(A) channels encoded by Kv1.4 and Kv4.2 regulate neuronal firing in the suprachiasmatic nucleus and circadian rhythms in locomotor activity.
Herzog et al., Saint Louis, United States. In J Neurosci, 2012
Kv1.4- and Kv4.2-encoded I(A) channels regulate the intrinsic excitability of SCN neurons during the day and night and determine the period and amplitude of circadian rhythms in SCN neuron firing and locomotor behavior.
Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.
Commons et al., Boston, United States. In Brain Res, 2012
This study demonistrated that Kcna4 gene expression in mouse dorsal raphe nucleus
N-glycosylation of the mammalian dipeptidyl aminopeptidase-like protein 10 (DPP10) regulates trafficking and interaction with Kv4 channels.
Sblattero et al., Novara, Italy. In Int J Biochem Cell Biol, 2012
demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 channels
Alternative splicing regulates kv3.1 polarized targeting to adjust maximal spiking frequency.
Gu et al., Columbus, United States. In J Biol Chem, 2012
alternative splicing controls neuronal firing rates by regulating the polarized targeting of Kv3.1 channels.
Incorporation of DPP6a and DPP6K variants in ternary Kv4 channel complex reconstitutes properties of A-type K current in rat cerebellar granule cells.
Pfaffinger et al., Houston, United States. In Plos One, 2011
The unique N-terminus of DPP6K modulates the effects of KChIP proteins, slowing recovery and producing a negative shift in the steady-state inactivation curve.
CNS autoimmune inflammation: RICK must NOD!
Li et al., Cleveland, United States. In Immunity, 2011
In this issue of Immunity, Shaw et al.
Mutations in voltage-gated potassium channel KCNC3 cause degenerative and developmental central nervous system phenotypes.
Pulst et al., Los Angeles, United States. In Nat Genet, 2006
This region contains KCNC3 (also known as Kv3.3), encoding a voltage-gated Shaw channel with enriched cerebellar expression.
Potassium and calcium channels in lymphocytes.
Cahalan et al., Stanford, United States. In Annu Rev Immunol, 1994
The genes encoding two K(V) channels, Kv1.3 (type n) and Kv3.1 (type l), have been cloned.
Margery Shaw, MD, JD: twice counselor.
Check, In Jama, 1982
Geneticist and lawyer Margery Shaw is profiled and the work of Houston's Institute for the Interprofessional Study of Health Law is discussed.
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