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Potassium voltage-gated channel, shaker-related subfamily, member 3

Kv1.3, MK3
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SF-1, CAN, MAPK, V1a, p38
Papers using Kv1.3 antibodies
Regulation of p21Waf1 expression and TNFa biosynthesis by glutathione modulators in PMA induced-THP1 differentiation: Involvement of JNK and ERK pathways
Supplier
Moens Ugo et al., In Journal of Molecular Signaling, 2006
... MK2 and MK3 antibodies were from Cell Signaling Technology (Danvers, MA, USA; ...
Papers on Kv1.3
Evaluation of distribution and sources of sewage molecular marker (LABs) in selected rivers and estuaries of Peninsular Malaysia.
New
Latif et al., Kuala Selangor, Malaysia. In Environ Sci Pollut Res Int, Dec 2015
The LABs ratio of internal to external isomers (I/E) in this study ranged from 0.56 at KH1 (upstream of Kedah River) to 1.35 at MK3 (Merbok Estuary) indicating that the rivers receive raw sewage and primary treatment effluents in the study area.
Toxins Targeting the Kv1.3 Channel: Potential Immunomodulators for Autoimmune Diseases.
Review
New
He et al., Wuhan, China. In Toxins (basel), May 2015
KV1.3 channels participate in modulating calcium signaling to induce T-cell proliferation, immune activation and cytokine production.
Impacts of climate change on distributions and diversity of ungulates on the Tibetan Plateau.
Tang et al., In Ecol Appl, 2015
We used three general circulation (MK3, HADCM3, MIROC3_2-MED) and three emissions scenarios (Bl, A1B, A2) to derive estimated future measurements of 14 environmental variables over three time periods (2020, 2050, 2080), and then modeled species distributions using these predicted environmental measurements for each time period under two dispersal hypotheses (full and zero, respectively).
Murine K2P5.1 Deficiency Has No Impact on Autoimmune Neuroinflammation due to Compensatory K2P3.1- and KV1.3-Dependent Mechanisms.
Meuth et al., Münster, Germany. In Int J Mol Sci, 2014
A compensatory upregulation of the potassium channels K2P3.1 and KV1.3 seems to counterbalance the deletion of K2P5.1.
Evidence of more ion channels inhibited by celecoxib: KV1.3 and L-type Ca(2+) channels.
Singh et al., Oulu, Finland. In Bmc Res Notes, 2014
FINDINGS: The channels examined in this study using patch-clamp and intracellular recording methods were human KV1.3 channels expressed in CHO cells, L-type Ca(2+) channels (LTCC) from guinea pig cardiomyocytes, and LTCCs from Drosophila larval body-wall muscles.
Roles of lymphocyte kv1.3-channels in the pathogenesis of renal diseases and novel therapeutic implications of targeting the channels.
Review
Kazama, Sendai, Japan. In Mediators Inflamm, 2014
Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes.
Future climate effects on suitability for growth of oil palms in Malaysia and Indonesia.
Lima et al., Braga, Portugal. In Sci Rep, 2014
Two Global Climate Models (GCMs), CSIRO-Mk3.0
The role of T cell potassium channels, KV1.3 and KCa3.1, in the inflammatory cascade in ulcerative colitis.
Review
Hansen, Vejle, Denmark. In Dan Med J, 2014
As long as the T cells are stimulated, the two potassium channels KV1.3 and KCa3.1 maintain the driving force for calcium influx, thus keeping the T cells activated.
What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition.
Review
Gaestel, In Biol Chem, 2013
The closely-related mitogen-activated protein kinase-activated protein kinases MK2 and MK3 are involved in both up- and down-regulation of inflammation in mammals and govern the inflammatory response at different regulatory levels of gene expression and with different kinetics.
Diet-induced obesity resistance of Kv1.3-/- mice is olfactory bulb dependent.
GeneRIF
Fadool et al., Tallahassee, United States. In J Neuroendocrinol, 2012
findings suggest that pathways activated in Kv1.3-/- that increased energy expenditure and led to resistance to DIO are olfactory bulb dependent
Protein kinase C (PKC) activity regulates functional effects of Kvβ1.3 subunit on KV1.5 channels: identification of a cardiac Kv1.5 channelosome.
GeneRIF
Valenzuela et al., Madrid, Spain. In J Biol Chem, 2012
and immunocytochemistry experiments revealed an association between K(v)1.5, K(v)beta1.3, the receptor for activated C kinase (RACK1), PKCbetaI, PKCbetaII, and PKCtheta.
Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis.
GeneRIF
Calabresi et al., Baltimore, United States. In J Immunol, 2012
Our data demonstrate that Kv1.3 plays an important role in Ag-specific activation of CD4+ T cells during the course of experimental autoimmune encephalomyelitis
The macrophage response towards LPS and its control through the p38(MAPK)-STAT3 axis.
Review
Häussinger et al., Düsseldorf, Germany. In Cell Signal, 2012
In this context regulation of suppressor of cytokine signaling (SOCS)3 expression and the recently described divergent regulatory roles of the two p38(MAPK)-activated protein kinases MK2 and MK3 for the regulation of LPS-induced NF-κB- and IRF3-mediated signal-transduction and gene expression, which includes the regulation of IFNβ, IL-10 and DUSP1, appears to play an important role.
Modulation of Kv1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex.
GeneRIF
Conforti et al., Cincinnati, United States. In Am J Physiol Cell Physiol, 2012
Selective knockdown of protein kinase A 1(PKAI) eliminates modulation of Kv1.3 channels by PKAI activation.
Kv1.3 channels can modulate cell proliferation during phenotypic switch by an ion-flux independent mechanism.
GeneRIF
Pérez-García et al., Valladolid, Spain. In Arterioscler Thromb Vasc Biol, 2012
the conserved upregulation of Kv1.3 on phenotypic modulation in several vascular beds makes this channel a good target to control unwanted vascular remodeling.
The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways.
Impact
Watts et al., Dundee, United Kingdom. In Nat Immunol, 2007
In addition, we identify in DCs a previously unknown configuration of the MAPK system whereby Rsk is activated not only by Erk but also by p38 through the intermediates MK2 and MK3.
MAPKAP kinases - MKs - two's company, three's a crowd.
Review
Impact
Gaestel, Hannover, Germany. In Nat Rev Mol Cell Biol, 2006
Downstream of mitogen-activated protein kinases (MAPKs), three structurally related MAPK-activated protein kinases (MAPKAPKs or MKs) - MK2, MK3 and MK5 - signal to diverse cellular targets.
Viral degradation of the MHC class I peptide loading complex.
Impact
Stevenson et al., Cambridge, United Kingdom. In Immunity, 2004
The murine gamma-herpesvirus-68 MK3 protein inhibits CD8(+) T cell recognition by ubiquitinating the cytoplasmic tails of classical MHC class I heavy chains.
Virus subversion of the MHC class I peptide-loading complex.
Impact
Hansen et al., Saint Louis, United States. In Immunity, 2003
The mK3 protein of gamma(2)-Herpesvirus 68 targets the degradation of nascent class I molecules via the ubiquitin/proteasome pathway.
MHC class I ubiquitination by a viral PHD/LAP finger protein.
Impact
Stevenson et al., Cambridge, United Kingdom. In Immunity, 2001
The murine gamma-herpesvirus-68 K3 (MK3) is a PHD/LAP finger protein that downregulates major histocompatibility complex (MHC) class I expression.
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