Biological effects of passive versus active scanning proton beams on human lung epithelial cells.
Loma Linda, United States. In Technol Cancer Res Treat, Feb 2015
In contrast, many more genes had >2-fold difference with ABS protons: BRCA1, BRCA2, CDC25A, CDC25C, CCNB2, CDK1, DMC1, DNMT1, E2F1, EXO1, FEN1, GADD45A, GTSE1, IL-6, JUN, KRAS, MDM4, PRC1, PTTG1, RAD51, RPA1, TNF, WT1, XRCC2, XRCC3 and XRCC6BP1.
The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
Oxford, United Kingdom. In Plos One, 2009
Several SNPs were found to be associated with changes in expression: in particular two with HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRB1, HLA-DRB4 and HLA-DRB5, one with ZFP57, one with CD58, two with IL7 and FAM164A, and one with FAM119B, TSFM and KUB3.
A different view on DNA amplifications indicates frequent, highly complex, and stable amplicons on 12q13-21 in glioma.
Homburg, Germany. In Mol Cancer Res, 2008
Expression analysis of the amplified region revealed 10 overexpressed genes (i.e., KUB3, CTDSP2, CDK4, OS-9, DCTN2, RAB3IP, FRS2, GAS41, MDM2, and RAP1B) that were consistently overexpressed in all cases that carried this amplification.
Glioblastoma multiforme: the role of DSB repair between genotype and phenotype.
Homburg, Germany. In Oncogene, 2008
Specifically, we address the role of DNA-PKcs and the novel potential end-joining factor KUB3 in maintaining the radioresistant phenotype, the interrelationship between genetic lesions and repair mechanisms, and new perspectives that emerge from the identification of glioblastoma stem cells.