Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract.
München, Germany. In Adv Exp Med Biol, 2005
Analysis of expression of 5-FU-(e.g., TS, DPD, and TP) and cisplatin-(e.g., ERCC1, ERCC4, GADD45A, and KU80) related genes, demonstrated an association of DPD expression with response and survival.
Non-homologous end-joining factors of Saccharomyces cerevisiae.
Bratislava, Slovakia. In Fems Microbiol Rev, 2004
The budding yeast Saccharomyces cerevisiae repairs DSB primarily by homologous recombination (HR), despite the presence of the KU70, KU80, DNA ligase IV and XRCC4 homologues, essential factors of the mammalian non-homologous end-joining (NHEJ) machinery.
Yeast DNA ligase IV mediates non-homologous DNA end joining.
Saint Louis, United States. In Nature, 1997
The discovery of homologues from the yeast Saccharomyces cerevisiae of the human Ku DNA-end-binding proteins (HDF1 and KU80) has established that this organism is capable of non-homologous double-strand end joining (NHEJ), a form of DNA double-strand break repair (DSBR) active in mammalian V(D)J recombination.