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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Kinase suppressor of ras 2

KSR2, hKSR-2, kinase suppressor of ras 2
Top mentioned proteins: KSR, ERK, Raf, Insulin, MAPK
Papers on KSR2
Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.
Li et al., Vienna, Austria. In Behav Brain Res, Jan 2016
These include members of PKP signalling modules of mitogen-activated protein kinase (MAP3K10, RAF1, KSR2), Ca2+/calmodulin-dependent protein kinase (CaMKIIα, DAPK1), protein kinase C (PRKCD) and protein phosphatases 1, 2A, 2B(3) previously implicated in various learning paradigms.
Coordination of Recombination with Meiotic Progression in the Caenorhabditis elegans Germline by KIN-18, a TAO Kinase That Regulates the Timing of MPK-1 Signaling.
Smolikove et al., Iowa City, United States. In Genetics, Jan 2016
Late progression defects in kin-18 mutants are suppressed by inhibiting an upstream activator of MPK-1 signaling, KSR-2.
Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.
Rotimi et al., Bethesda, United States. In Mol Genet Metab, Dec 2015
OR=1.59) and rs7964157[T] near KSR2 associated with reduced MetS risk (P=4.52×10(-8),
Ultrastructural study of spermatogenesis in KSR2 deficient mice.
Giurisato et al., Siena, Italy. In Transgenic Res, Aug 2015
The aim of this study was to investigate the spermatogenesis in ksr2(-/-) mice.
KSR1 is coordinately regulated with Notch signaling and oxidative phosphorylation in thyroid cancer.
Jo et al., Seoul, South Korea. In J Mol Endocrinol, Apr 2015
In addition, GSEA showed that high expression of KSR2 and connector enhancer of KSR1 (CNKSR1) also coordinately upregulated Notch signaling (KSR2: nominal P=0.0097,
Obesity-dependent dysregulation of glucose homeostasis in kinase suppressor of ras 2-/- mice.
Lewis et al., Omaha, United States. In Physiol Rep, 2014
Disruption of KSR2 in humans and mice decreases metabolic rate and induces obesity, coincident with dysregulation of glucose homeostasis.
The KSR2-calcineurin complex regulates STIM1-ORAI1 dynamics and store-operated calcium entry (SOCE).
Sorrentino et al., Siena, Italy. In Mol Biol Cell, 2014
The present study provides evidence for a direct involvement of kinase suppressor of Ras 2 (KSR2) in SOCE.
The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons.
Morrison et al., Frederick, United States. In Curr Biol, 2014
Connector enhancer of KSR-2 (CNK2) is a neuronally expressed scaffold recently implicated in nonsyndromic, X-linked intellectual disability (NS-XLID) [1-3].
Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm.
Lewis et al., Omaha, United States. In Febs Open Bio, 2013
The kinase suppressor of Ras 2 (KSR2) is a scaffold protein for the extracellular signal-regulated protein kinase (ERK) signaling pathway.
Distinct DNA-based epigenetic switches trigger transcriptional activation of silent genes in human dermal fibroblasts.
Sugiyama et al., Kyoto, Japan. In Sci Rep, 2013
QRT-PCR validated the microarray data, and some SAHA-PIPs activated therapeutically significant genes like KSR2.
KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.
Farooqi et al., In Cell, 2013
Kinase suppressor of Ras 2 (KSR2) is an intracellular scaffolding protein involved in multiple signaling pathways.
miR-31 regulates interleukin 2 and kinase suppressor of ras 2 during T cell activation.
Xia et al., Shanghai, China. In Genes Immun, 2013
To gain more insights into the regulatory mechanism, we performed a bioinformatic analysis and found miR-31 potentially targeted kinase suppressor of ras 2 (KSR2), a repression factor of Ras2 kinase.
Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK.
Lewis et al., Omaha, United States. In Mol Cell Biol, 2012
KSR2 is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.
Studzinski et al., Newark, United States. In J Cell Physiol, 2011
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.
Profound obesity secondary to hyperphagia in mice lacking kinase suppressor of ras 2.
Powell et al., The Woodlands, United States. In Obesity (silver Spring), 2011
The metabolic phenotype of KSR2 heterozygous (KSR2(+/minus;)) and KSR2(-/-) mice suggests that human KSR2 variants may contribute to a similar phenotype linked to human chromosome 12q24
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.
Barford et al., London, United Kingdom. In Nature, 2011
KSR interacts with a regulatory Raf molecule in cis to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf molecule in trans
Kinase suppressor of Ras 2 is involved in regulation of cell proliferation and is up-regulated in human invasive ductal carcinomas of breast.
Souchelnytskyi et al., Stockholm, Sweden. In Exp Oncol, 2010
The involvement of KSR2 in regulation of cell proliferation was predicted by a KSR2-centered network analysis.
KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.
Lewis et al., Omaha, United States. In Cell Metab, 2009
KSR2 regulates AMPK-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.
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