Tissue-specificity of heparan sulfate biosynthetic machinery in cancer.
Novosibirsk, Russia. In Cell Adh Migr, Dec 2015
To reveal cancer-related changes in transcriptional pattern of HS biosynthetic system, the expression of HS metabolism-involved genes (EXT1/2, NDST1/2, GLCE, 3OST1/HS3ST1, SULF1/2, HPSE) in human normal (fibroblasts, PNT2) and cancer (MCF7, LNCaP, PC3, DU145, H157, H647, A549, U2020, U87, HT116, KRC/Y) cell lines and breast, prostate, colon tumors was studied.
Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
New York City, United States. In J Clin Invest, 2013
Mice deficient in Schnurri-3 (SHN3; also known as HIVEP3) display increased bone formation, but harnessing this observation for therapeutic benefit requires an improved understanding of how SHN3 functions in osteoblasts.