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Zinc finger protein 10

KOX1, ZNF10, zinc finger protein KOX1
The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TIF1beta, Nox4, ACID, CAN, Haptoglobin
Papers on KOX1
ZNF10 inhibits HIV-1 LTR activity through interaction with NF-κB and Sp1 binding motifs.
New
Takaku et al., Narashino, Japan. In Febs Lett, Aug 2015
Of the 5 identified KRAB-ZFPs, the expression of ZNF10 significantly enhanced the transcriptional repression activity of the LTR compared with other ZNFs.
The B-subdomain of the Xenopus laevis XFIN KRAB-AB domain is responsible for its weaker transcriptional repressor activity compared to human ZNF10/Kox1.
Lorenz et al., Rostock, Germany. In Plos One, 2013
The prototype KRAB domain initially identified in ZNF10/KOX1 encompasses two subdomains A and B that are found in hundreds of zinc finger transcription factors studied in human and murine genomes.
Growth inhibition of HeLa cells is a conserved feature of high-risk human papillomavirus E8^E2C proteins and can also be achieved by an artificial repressor protein.
Stubenrauch et al., Tübingen, Germany. In J Virol, 2011
Furthermore, we demonstrate that the 31E8 domain can be functionally replaced by the KRAB repression domain derived from KOX1.
Development of cell cultures that express hepatitis B virus to high levels and accumulate cccDNA.
Loeb et al., Madison, United States. In J Virol Methods, 2010
Cell lines derived from hepatoma cells Huh7 and HepG2 were created that express Epstein-Barr virus (EBV) nuclear antigen-1 and a fusion protein of the Tet repressor and Kox1 transcriptional repression domain stably.
Sleeping beauty transposase has an affinity for heterochromatin conformation.
Takeda et al., Suita, Japan. In Mol Cell Biol, 2007
Heterochromatin conformation was introduced into the SB transposon by using a tetracycline-controlled transrepressor (tTR) protein, consisting of a tetracycline repressor (TetR) fused to the Kruppel-associated box (KRAB) domain of human KOX1 through tetracycline operator (tetO) sequences.
Involvement of HP1alpha protein in irreversible transcriptional inactivation by antiestrogens in breast cancer cells.
Badia et al., Montpellier, France. In Febs Lett, 2005
Chimeras composed of either HP1alpha or the Krupple-associated box (KRAB) module of KOX-1 protein (known to repress gene expression by recruitment of HP1 proteins), fused to the estrogen receptor (ER)-DNA binding domain (DBD) and the androgen receptor (AR)-ligand binding domain (LBD) were generated and appeared as potent transcriptional repressors.
[Construction of a SV40 promoter specific artificial transcription factor].
Huang et al., Beijing, China. In Sheng Wu Gong Cheng Xue Bao, 2003
The three-finger DNA-binding domain targeted to SV40 promoter, that is, zinc finger sequences on clone 3, was fused to KOX1 suppression domain KRAB and cloned into pcDNA3.1 (+) (which expression product was artificial transcription factor).
Inhibition of herpes simplex virus 1 gene expression by designer zinc-finger transcription factors.
Klug et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2003
Peptides containing either three or six fingers, targeted to a viral promoter, were engineered as fusions with a KOX-1 transcription repression domain.
Repression of the HIV-1 5' LTR promoter and inhibition of HIV-1 replication by using engineered zinc-finger transcription factors.
Choo et al., London, United Kingdom. In Proc Natl Acad Sci U S A, 2003
In this study, eight three-zinc-finger proteins (ZFPs) that bound HIV-1 sequences in vitro were engineered into transcription repressors by linking them to the Krüppel-associated box (KRAB) repressor domain (KOX1).
The KOX zinc finger genes: genome wide mapping of 368 ZNF PAC clones with zinc finger gene clusters predominantly in 23 chromosomal loci are confirmed by human sequences annotated in EnsEMBL.
Thiesen et al., Paris, France. In Cytogenet Genome Res, 2001
The chromosome locations of 368 human Kruppel-type zinc finger (ZNF) PAC clones were physically mapped by FISH to human chromosomes in support of recent efforts of assigning KOX cDNAs (KOX1-KOX32) to zinc finger gene clusters.
Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation.
Thiesen et al., Rostock, Germany. In Biol Chem, 2001
The KRAB domain of human Kox1, a member of the KRAB C2H2 zinc finger family, confers strong transcriptional repressor activities even to remote promoter positions.
Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain.
Rauscher et al., Philadelphia, United States. In J Biol Chem, 2000
Using purified components, a combination of biochemical and biophysical analyses has revealed that the KRAB domain from the KOX1 protein is predominantly a monomer and that the KAP-1 protein is predominantly a trimer in solution.
Inhibition of human hematopoietic tumor formation by targeting a repressor Myb-KRAB to DNA.
Moelling et al., Zürich, Switzerland. In Cancer Gene Ther, 2000
To achieve a specific inhibition of hematopoietic tumor growth, an inducible fusion protein consisting of the Myb DNA binding domain (DBD) and the active repressor domain KRAB, the Krüppel-associated box of the developmental zinc-finger protein KOX-1, was generated.
Repression of the human immunodeficiency virus type 1 promoter by the human KRAB domain results in inhibition of virus production.
Schneider et al., Freiburg, Germany. In Biochim Biophys Acta, 1999
The KRAB domain from the human zinc finger protein KOX1 was combined with the DNA binding domain of the Escherichia coli tetracycline repressor (TetR).
TIF1gamma, a novel member of the transcriptional intermediary factor 1 family.
de Thé et al., Saint-Louis, France. In Oncogene, 1999
Whereas TIF1alpha and TIF1beta were previously found to interact with the KRAB silencing domain of KOX1 and with the HP1alpha, MODI (HP1beta) and MOD2 (HP1gamma) heterochromatinic proteins, suggesting that they may participate in a complex involved in heterochromatin-induced gene repression, TIF1gamma does not interact with either the KRAB domain of KOX1 or the HP1 proteins.
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