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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Klotho

Klotho, K-L
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FGF23, AGE, CAN, HAD, Parathyroid Hormone
Papers using Klotho antibodies
From endoplasmic-reticulum stress to the inflammatory response
Supplier
Wu Jianqing et al., In Journal of Experimental & Clinical Cancer Research : CR, 2007
... Klotho-directed stealth shRNA duplex oligoribonucleotides and control shRNAc were also designed and purchased from OriGene (Rockville, MD, USA) ...
Papers on Klotho
GH TREATMENT increases SERUM FGF23 AND KLOTHO levels IN GH DEFICIENT CHILDREN.
New
Chrysis et al., Pátrai, Greece. In Eur J Endocrinol, Feb 2016
The phosphaturic FGF23/klotho axis is a major regulator of phosphate homeostasis and therefore an intact FGF23/Klotho axis is important for normal linear growth.
FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice.
New
Hurley et al., Farmington, United States. In J Cell Biochem, Feb 2016
UNASSIGNED: High molecular weight FGF2 transgenic (HMWTg) mouse phenocopies the Hyp mouse, homolog of human X-linked hypophosphatemic rickets with hypophosphatemis and abnormal FGF23, FGFR, Klotho signaling in kidney.
NFκBiz protein downregulation in acute kidney injury: Modulation of inflammation and survival in tubular cells.
New
Sanchez-Niño et al., Madrid, Spain. In Biochim Biophys Acta, Feb 2016
NFκBiz targeting increased chemokine production and dampened Klotho downregulation induced by TWEAK, without modulating cell proliferation.
Up-Regulation of FGF23 Release by Aldosterone.
New
Lang et al., Tübingen, Germany. In Biochem Biophys Res Commun, Feb 2016
Excessive FGF23 levels and hyperaldosteronism are further observed in Klotho-deficient mice.
Fibroblast growth factors, old kids on the new block.
Review
New
Wang et al., Wenzhou, China. In Semin Cell Dev Biol, Feb 2016
The FGF signaling axis is highly complex due to the existence of multiple isoforms of both ligands and receptors, as well as cofactors that include the chemically heterogeneous heparan sulfate (HS) cofactors, and in the case of endocrine FGFs, the Klotho coreceptors.
Targeting local vascular and systemic consequences of inflammation on vascular and cardiac valve calcification.
New
Ortiz et al., Madrid, Spain. In Expert Opin Ther Targets, Jan 2016
Inflammatory cytokines, such as the TNF superfamily and IL-6 superfamily, and inflammation-related transcription factor NF-κB promote calcification in cultured vascular smooth muscle cells, valvular interstitial cells, or experimental animal models through direct effects, but also indirectly by decreasing circulating Fetuin A or Klotho levels.
FGF21 Regulates Sweet and Alcohol Preference.
New
Impact
Kliewer et al., Cambridge, United States. In Cell Metab, Jan 2016
In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens.
[Research Progress of Klotho].
Review
New
Qi et al., In Sheng Li Ke Xue Jin Zhan, Aug 2015
Klotho, a newly identified anti-aging gene, can be regulated by many factors, such as calcitonin gene-related peptide, fibroblast growth factor 2 could up-regulate Klotho expression; whereas renin-angiotensin system, urinary toxins, inflammation and oxidative stress could reduce expression of Klotho.
Detection of FGF15 in plasma by stable isotope standards and capture by anti-peptide antibodies and targeted mass spectrometry.
New
Impact
Mangelsdorf et al., Dallas, United States. In Cell Metab, Jul 2015
Consistent with the proposed endocrine role for FGF15 in liver, mice lacking hepatocyte expression of the obligate FGF15 co-receptor, β-Klotho, have increased bile acid synthesis and reduced glycogen storage despite having supraphysiological plasma FGF15 concentrations.
Molecular basis of Klotho: from gene to function in aging.
Review
New
Impact
Sun et al., Oklahoma City, United States. In Endocr Rev, Apr 2015
The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-suppressor gene, has generated tremendous interest and has advanced understanding of the aging process.
FGF21 regulates metabolism and circadian behavior by acting on the nervous system.
Impact
Kliewer et al., Dallas, United States. In Nat Med, 2013
FGF21 signals through a heteromeric cell-surface receptor composed of one of three FGF receptors (FGFR1c, FGFR2c or FGFR3c) in complex with β-Klotho, a single-pass transmembrane protein that is enriched in metabolic tissues.
Forever (FGF) 21.
Impact
Bass, Evanston, United States. In Nat Med, 2013
The fibroblast growth factor 21 (FGF21)-β-Klotho pathway orchestrates a switch to oxidative metabolism during fasting and starvation and has been implicated as a signal connecting nutrition, growth, reproduction and longevity.
Klotho inhibits the capacity of cell migration and invasion in cervical cancer.
GeneRIF
Lee et al., Seoul, South Korea. In Oncol Rep, 2012
Klotho regulates tumor invasion through the epithelial mesenchymal transition process.
Plasma soluble α-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters.
GeneRIF
Chrousos et al., Athens, Greece. In Eur J Endocrinol, 2012
Evaluation of circulating concentrations of alpha-KL protein during the first month of age in preterm and full-term infants and to unravel possible associations with anthropometric (body weight and length) and metabolic parameters.
Antiaging gene Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 β-cells.
GeneRIF
Sun et al., Oklahoma City, United States. In Endocrinology, 2012
Klotho enhances glucose-induced insulin secretion by up-regulating plasma membrane levels of TRPV2 in MIN6 beta-cells
Serum soluble α-klotho in hemodialysis patients.
GeneRIF
Hosoya et al., Tokyo, Japan. In Clin Nephrol, 2012
The serum alpha-klotho level was lower in hemodialysis patients than in healthy persons. Serum phosphorus level was independently associated with the serum salphaKl level.
[Aging and tubulo-interstitial injuries (possible implications of Klotho): renal senescence hypothesis].
Review
GeneRIF
Satoh et al., In Nihon Jinzo Gakkai Shi, 2011
Its implication in renal senescence. (review)
The intact nephron hypothesis: the concept and its implications for phosphate management in CKD-related mineral and bone disorder.
Review
Slatopolsky, Saint Louis, United States. In Kidney Int, 2011
Vitamin D receptor, Ca(2+) sensing receptor, and Klotho-fibroblast growth factor (FGF) receptor-1 complex are all significantly decreased in the parathyroid glands of patients with CKD.
Phosphate and FGF-23.
Review
Jüppner, Boston, United States. In Kidney Int, 2011
At the same time, responsiveness to FGF-23 declines as the number of intact nephrons declines, which is associated with reduced expression of Klotho, the co-receptor required for FGF-23 signaling.
Phosphate and Klotho.
Review
Kuro-O, Dallas, United States. In Kidney Int, 2011
Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23.
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