Fibroblast growth factors, old kids on the new block.
Wenzhou, China. In Semin Cell Dev Biol, Feb 2016
The FGF signaling axis is highly complex due to the existence of multiple isoforms of both ligands and receptors, as well as cofactors that include the chemically heterogeneous heparan sulfate (HS) cofactors, and in the case of endocrine FGFs, the Klotho coreceptors.
FGF21 Regulates Sweet and Alcohol Preference.
Cambridge, United States. In Cell Metab, Jan 2016
In mice, these effects require the FGF21 co-receptor β-Klotho in the central nervous system and correlate with reductions in dopamine concentrations in the nucleus accumbens.
[Research Progress of Klotho].
In Sheng Li Ke Xue Jin Zhan, Aug 2015
Klotho, a newly identified anti-aging gene, can be regulated by many factors, such as calcitonin gene-related peptide, fibroblast growth factor 2 could up-regulate Klotho expression; whereas renin-angiotensin system, urinary toxins, inflammation and oxidative stress could reduce expression of Klotho.
Molecular basis of Klotho: from gene to function in aging.
Oklahoma City, United States. In Endocr Rev, Apr 2015
The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-suppressor gene, has generated tremendous interest and has advanced understanding of the aging process.
Forever (FGF) 21.
Evanston, United States. In Nat Med, 2013
The fibroblast growth factor 21 (FGF21)-β-Klotho pathway orchestrates a switch to oxidative metabolism during fasting and starvation and has been implicated as a signal connecting nutrition, growth, reproduction and longevity.
Serum soluble α-klotho in hemodialysis patients.
Tokyo, Japan. In Clin Nephrol, 2012
The serum alpha-klotho level was lower in hemodialysis patients than in healthy persons. Serum phosphorus level was independently associated with the serum salphaKl level.
Phosphate and FGF-23.
Boston, United States. In Kidney Int, 2011
At the same time, responsiveness to FGF-23 declines as the number of intact nephrons declines, which is associated with reduced expression of Klotho, the co-receptor required for FGF-23 signaling.
Phosphate and Klotho.
Dallas, United States. In Kidney Int, 2011
Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23.