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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Kallikrein-related peptidase 9

KLK9, mGK-9, KLK-L3
The protein encoded by this gene is a kallikrein-related serine protease. This gene is activated by steroid hormones in a human breast cancer cell line, making it a good marker for cancer detection. The encoded protein is found primarily in the cytoplasm.[provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: Kallikrein, HNP, KLK10, hK2, KLK6
Papers on KLK9
Increased Klk9 Urinary Excretion Is Associated to Hypertension-Induced Cardiovascular Damage and Renal Alterations.
Martínez-Salgado et al., Salamanca, Spain. In Medicine (baltimore), Oct 2015
Presently, there are no biomarkers for the detection of hypertensive target organ damage, most outstandingly including blood vessels, the heart, and the kidneys.We aimed to validate the usefulness of the urinary excretion of the serine protease kallikrein-related peptidase 9 (KLK9) as a biomarker of hypertension-induced target organ damage.Urinary, plasma, and renal tissue levels of KLK9 were measured by the Western blot in different rat models of hypertension, including angiotensin-II infusion, DOCA-salt, L-NAME administration, and spontaneous hypertension.
Expression and bioregulation of the kallikrein-related peptidases family in the human neutrophil.
Figueroa et al., Valdivia, Chile. In Innate Immun, Aug 2015
Nevertheless, mRNAs for KLK2, KLK5, KLK6 and KLK9 that were previously undetectable appeared after challenging with a mixture of cytokines.
Prognostic significance of multiple kallikreins in high-grade astrocytoma.
Scarisbrick et al., Rochester, United States. In Bmc Cancer, 2014
METHODS: In this study we determined KLK1, KLK6, KLK7, KLK8, KLK9 and KLK10 protein expression in two independent tissue microarrays containing 60 grade IV and 8 grade III astrocytoma samples.
Transcriptional landscape of psoriasis identifies the involvement of IL36 and IL36RN.
Kingo et al., Tartu, Estonia. In Bmc Genomics, 2014
Namely, KLK9, OAS2, OAS3, PLA2G, IL36G, IL36RN were found to be significantly and consistently related to the psoriatic lesions and this finding is supported also by previous studies.
Kallikrein cascades in traumatic spinal cord injury: in vitro evidence for roles in axonopathy and neuron degeneration.
Scarisbrick et al., Toronto, Canada. In J Neuropathol Exp Neurol, 2013
To illuminate their contributions to the pathophysiology of spinal cord injury (SCI), we evaluated acute through chronic changes in the immunohistochemical appearance of 6 KLKs (KLK1, KLK5, KLK6, KLK7, KLK8, and KLK9) in postmortem human traumatic SCI cases, quantified their RNA expression levels in experimental murine SCI, and assessed the impact of recombinant forms of each enzyme toward murine cortical neurons in vitro.
Copy number variants in the kallikrein gene cluster.
Halldén et al., Malmö, Sweden. In Plos One, 2012
Two deletions were identified: one 2235-bp deletion in KLK9 present in 1.2% of alleles, and one 3394-bp deletion in KLK15 present in 4.0% of alleles.
The canine kallikrein-related peptidases 9 and 10: structural characterization and expression in mammary cancer.
Karagiannis et al., Thessaloníki, Greece. In Mamm Genome, 2009
Specifically, the predicted mRNA harbors a 183-bp segment, which constitutes part of (CANFA)KLK10 intron I, and a 756-bp sequence that corresponds to the nonpreviously characterized (CANFA)KLK9 coding region.
A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15.
Blaber et al., Tallahassee, United States. In Biol Chem, 2009
The missing profiles in the prior report, involving KLK9, 10, and 15, are now described.
In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families.
Diamandis et al., Toronto, Canada. In Genomics, 2006
One consisted of KLK4, KLK5, and KLK14; another of KLK9, KLK11, and KLK15; a third of KLK10 and KLK12; a fourth of KLK6 and KLK13; and finally one of KLK8 and the classical kallikreins (KLK1, KLK2, and KLK3).
Human tissue kallikrein 9: production of recombinant proteins and specific antibodies.
Diamandis et al., Toronto, Canada. In Biol Chem, 2006
Human tissue kallikrein 9 (KLK9) is a newly identified member of the tissue kallikrein gene family.
The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer.
Diamandis et al., Toronto, Canada. In Breast Cancer Res Treat, 2003
KLK9 is a newly discovered human kallikrein gene that is expressed in several tissues including thymus, spinal cord, testis, prostate, breast, and ovary.
Quantitative expression of the human kallikrein gene 9 (KLK9) in ovarian cancer: a new independent and favorable prognostic marker.
Katsaros et al., Toronto, Canada. In Cancer Res, 2001
KLK9 is a newly discovered human kallikrein gene that is expressed in several tissues including thymus, testis, spinal cord, salivary gland, ovary, and skin.
Expression of the kallikrein gene family in normal and Alzheimer's disease brain.
Fahnestock et al., Hamilton, Canada. In Neuroreport, 2001
KLK9 is expressed in cortex but not hippocampus, whereas KLK2, 3, 12 and 15 are not expressed in either tissue.
The new human kallikrein gene family: implications in carcinogenesis.
Obiezu et al., Toronto, Canada. In Trends Endocrinol Metab, 2000
Another five putative kallikrein genes, provisionally named KLK-L2, KLK-L3, KLK-L4, KLK-L5 and KLK-L6, have also been identified.
The transcriptional regulatory strategy of the rat tissue kallikrein gene family.
Hammer et al., Dallas, United States. In Genes Funct, 1997
Rat (r) genes KLK1, KLK2, KLK3, KLK7, KLK8, KLK9 and KLK10 on four different P1 clones were all correctly expressed at high levels in the submandibular glands of transgenic mice and in general showed the correct extra-salivary patterns characteristic of each family member.
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