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Kallikrein-related peptidase 6

KLK6, kallikrein 6, KLK7, hK6, kallikrein 7, hK7, protease M, SCCE
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on KLK6
TH2 cytokines increase kallikrein 7 expression and function in patients with atopic dermatitis.
Iwatsuki et al., In J Allergy Clin Immunol, 2012
The enhancement of protease activity through increased KLK7 expression by the TH2 cytokines IL-4 and IL-13 might be an important factor for mechanical and chemical epidermal barrier dysfunction in patients with atopic dermatitis.
Lymph node tissue kallikrein-related peptidase 6 mRNA: a progression marker for colorectal cancer.
Hammarström et al., Umeå, Sweden. In Br J Cancer, 2012
in colorectal cancer patients, lymph node KLK6 positivity indicated presence of aggressive tumour cells associated with poor prognosis and high risk of tumour recurrence
Upregulation and secretion of kallikrein-related peptidase 6 (KLK6) in gastric cancer.
Lee et al., Taejŏn, South Korea. In Tumour Biol, 2012
KLK6 is significantly upregulated and secreted in gastric cancer tissues and sera, suggesting that KLK6 might be used as a potential biomarker and therapeutic target for gastric cancer.
Kallikrein 6 is a novel molecular trigger of reactive astrogliosis.
Vandell et al., Rochester, United States. In Biol Chem, 2012
KLK6 is positioned to serve as a molecular trigger of select physiological processes involved in the development of astrogliosis
Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients.
Magdolen et al., München, Germany. In Biol Chem, 2012
KLK6 expressed by stromal cells may considerably contribute to the aggressiveness of ovarian cancer
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