Endoplasmic reticulum stress: key promoter of rosacea pathogenesis.
Osnabrück, Germany. In Exp Dermatol, 2014
Recent scientific interest in the pathogenesis of rosacea focuses on abnormally high facial skin levels of cathelicidin and the trypsin-like serine protease kallikrein 5 (KLK5) that cleaves the cathelicidin precursor protein into the bioactive fragment LL-37, which exerts crucial proinflammatory, angiogenic and antimicrobial activities.
Netherton syndrome: skin inflammation and allergy by loss of protease inhibition.
Paris, France. In Cell Tissue Res, 2013
In vitro and in vivo studies in murine models and in NS patients have cast light on the pathogenesis of the disease and shown that LEKTI deficiency results in unopposed kallikrein-related peptidase 5 (KLK5) and KLK7 activities and to the overactivity of a new epidermal protease, elastase 2 (ELA2).