Uterine ALK3 is essential during the window of implantation.
Houston, United States. In Proc Natl Acad Sci U S A, Feb 2016
We determined that dual transcriptional regulation of Kruppel-like factor 15 (Klf15), by both the transforming growth factor β (TGF-β) transcription factor SMAD family member 4 (SMAD4) and progesterone receptor (PR), is necessary to inhibit uterine epithelial cell proliferation, a key step for embryo implantation.
KLF15 Establishes the Landscape of Diurnal Expression in the Heart.
Cleveland, United States. In Cell Rep, Jan 2016
Here, we show that kruppel-like factor 15 (KLF15) governs a biphasic transcriptomic oscillation in the heart with a maximum ATP production phase and a remodeling and repair phase corresponding to the active and resting phase of a rodent.
Branched-chain amino acids in metabolic signalling and insulin resistance.
United States. In Nat Rev Endocrinol, 2014
Research on the role of individual and model-dependent differences in BCAA metabolism is needed, as several genes (BCKDHA, PPM1K, IVD and KLF15) have been designated as candidate genes for obesity and/or T2DM in humans, and distinct phenotypes of tissue-specific branched chain ketoacid dehydrogenase complex activity have been detected in animal models of obesity and T2DM.
Novel excitation-contraction coupling related genes reveal aspects of muscle weakness beyond atrophy-new hopes for treatment of musculoskeletal diseases.
Columbus, United States. In Front Physiol, 2013
In this review, we have focused on the unique function of new genes/proteins (i.e., MTMR14, MG29, sarcalumenin, KLF15) that during the last few years have helped provide novel insights about muscle function in health and disease, muscle fatigue, muscle metabolism, and muscle aging.
Circadian rhythms govern cardiac repolarization and arrhythmogenesis.
Cleveland, United States. In Nature, 2012
Specifically, we show that cardiac ion-channel expression and QT-interval duration (an index of myocardial repolarization) exhibit endogenous circadian rhythmicity under the control of a clock-dependent oscillator, krüppel-like factor 15 (Klf15).
Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes.
Seoul, South Korea. In Iubmb Life, 2007
These include MyoD, MEF2A, GEF, TNF-alpha, TR-1alpha, KLF15, SREBP-1c, C/EBP-alpha, O/E-1, free fatty acids, PAPRgamma, LXRalpha, NF-1, etc.