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Kruppel-like factor 12

KLF12, AP-2rep
Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: KLF5, p15, KLF2, c-Myc, CAN
Papers on KLF12
Sustained viral response and treatment-induced cytopenia correlate with SLCs and KLF12 genotypes in interferon/ribavirin-treated Chinese chronic hepatitis C patients.
New
Niu et al., Changchun, China. In J Gastroenterol Hepatol, Feb 2016
BACKGROUND AND AIM: Genetic variations in solute carrier (SLC) genes are associated with liver diseases, and Kruppel-like factor 12 (KLF12) affects the b chain of hemoglobin.
Tumour-suppression function of KLF12 through regulation of anoikis.
New
Downward et al., London, United Kingdom. In Oncogene, Nov 2015
We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, is downregulated in lung cancer cell lines that have been selected to grow in the absence of cell adhesion.
p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses.
New
Hermeking et al., München, Germany. In Mol Cell Proteomics, Oct 2015
Furthermore, KLF12, HMGB1 and CIT mRNAs were confirmed as direct targets of the p53-induced miR-34a, miR-205 and miR-486-5p, respectively.
Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism.
New
Impact
Ma et al., Wuhan, China. In Nat Genet, Feb 2015
Beyond recalculating frequencies for the previously reported frequent integration sites POU5F1B (9.7%), FHIT (8.7%), KLF12 (7.8%), KLF5 (6.8%), LRP1B (5.8%) and LEPREL1 (4.9%), we discovered new hot spots HMGA2 (7.8%), DLG2 (4.9%) and SEMA3D (4.9%).
MicroRNA-181a is involved in the regulation of human endometrial stromal cell decidualization by inhibiting Krüppel-like factor 12.
Hu et al., Nanjing, China. In Reprod Biol Endocrinol, 2014
Luciferase reporter assay, western blotting, qRT-PCR, and immunofluorescence assay were carried out to identify the relationship between miR-181a and Krüppel-like factor 12 (KLF12).
Krüppel-like factor 12 is a novel negative regulator of forkhead box O1 expression: a potential role in impaired decidualization.
Yan et al., Nanjing, China. In Reprod Biol Endocrinol, 2014
Krüppel-like factor 12 (KLF12) is a negative regulator of endometrial decidualization in vitro.
miR-382 inhibits tumor growth and enhance chemosensitivity in osteosarcoma.
Wang et al., Beijing, China. In Oncotarget, 2014
Overexpression of miR-382 inhibited cell growth and chemoresistance by targeting KLF12 and HIPK3, respectively.
Gene expression profiling reveals distinct molecular signatures associated with the rupture of intracranial aneurysm.
Inoue et al., Tokushima, Japan. In Stroke, 2014
The expressions of Krüppel-like family of transcription factors (KLF2, KLF12, and KLF15), which were anti-inflammatory regulators, and CDKN2A, which was located on chromosome 9p21 that was the most consistently replicated locus in genome-wide association studies of IA, were also downregulated.
Genome-wide analysis of esophageal adenocarcinoma yields specific copy number aberrations that correlate with prognosis.
Barbour et al., Brisbane, Australia. In Genes Chromosomes Cancer, 2014
Regions of frequent amplification included oncogenes such as EGFR, MYC, KLF12, and ERBB2, while frequently deleted regions included tumor suppressor genes such as CDKN2A/B, PTPRD, FHIT, and SMAD4.
A study of gene expression markers for predictive significance for bevacizumab benefit in patients with metastatic colon cancer: a translational research study of the Hellenic Cooperative Oncology Group (HeCOG).
Fountzilas et al., Ioánnina, Greece. In Bmc Cancer, 2013
RESULTS: Five genes were significantly correlated to 8-month progression-free status in the Test set: overexpression of KLF12 and downregulation of AGR2, ALDH6A1, MCM5, TFF2.
Krüppel-like factor 12 negatively regulates human endometrial stromal cell decidualization.
Sun et al., Nanjing, China. In Biochem Biophys Res Commun, 2013
However, the specific role of KLF12 in endometrium development has not yet been described.
Single-cell mRNA profiling identifies progenitor subclasses in neurospheres.
Ahmed et al., Singapore, Singapore. In Stem Cells Dev, 2013
One cell population [cluster unsorted (US) 1] expresses high Bmi1 and Hes5 and low Myc and Klf12.
Association of protein tyrosine phosphatase non-receptor 22 (PTPN22) rs2476601 and Kruppel-like factor 12 (KLF12) rs1324913 single nucleotide polymorphisms with rheumatoid arthritis in a Latvian population.
GeneRIF
Nikitina-Zake et al., In Scand J Rheumatol, 2011
The KLF12 rs1324913 A allele homozygous genotype is a possible predictor of Rheumatoid Arthritis.
No evidence of association of the KLF12 gene with rheumatoid arthritis in Spanish and Dutch cohorts and a meta-analysis of published data.
GeneRIF
Martín et al., Granada, Spain. In Hum Immunol, 2011
no association of genetic polymorphism with rheumatoid arthritis in Spanish and Dutch cohorts
No evidence for association of the KLF12 gene with rheumatoid arthritis in a large UK cohort.
GeneRIF
Barton et al., In Ann Rheum Dis, 2010
In a large UK cohort of patients with rheumatoid arthritis, results have failed to add to the evidence for association at the KLF12 locus reported to be associated with rheumatoid arthritis in independent Spanish cohorts.
A functionally relevant IRF5 haplotype is associated with reduced risk to Wegener's granulomatosis.
Epplen et al., Bochum, Germany. In J Mol Med (berl), 2010
Thereof, we have evaluated the relevance of the most promising ones in WG. 22 single nucleotide polymorphisms (SNPs) within or in the vicinity of CCL21, CD40, CDK6, IL21, IL2RB, IRF5, KIF5A, KLF12, MMEL1, PRKCQ, STAT4, TNFAIP3, and TRAF1/C5 have been genotyped in >600 German WG cases and >800 matched controls.
Krüppel-like factor 12 plays a significant role in poorly differentiated gastric cancer progression.
GeneRIF
Shibata et al., Tokyo, Japan. In Int J Cancer, 2009
Overexpression of Kruppel-like factor 12 is associated with gastric cancer progression.
Identification and characterization of novel polymorphisms in the basal promoter of the human transporter, MATE1.
Giacomini et al., Seoul, South Korea. In Pharmacogenet Genomics, 2009
Two transcription factors, activating protein-1 (AP-1) and activating protein-2 repressor (AP-2rep), were predicted to bind to the promoter in the region of g.-66T>C.
Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility.
GeneRIF
Marsal et al., Barcelona, Spain. In Arthritis Rheum, 2008
KLF12 as a new susceptibility gene for rheumatoid arthritis.
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