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Kinesin light chain 2

KLC2, kinesin light chain 2
This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, CAN, KIF5B, JNK, c-Myc
Papers on KLC2
Overexpression of KLC2 due to a homozygous deletion in the non-coding region causes SPOAN syndrome.
New
Santos et al., São Paulo, Brazil. In Hum Mol Genet, Jan 2016
located at the non-coding upstream region of the KLC2 gene.
Interactome analysis reveals that FAM161A, deficient in recessive retinitis pigmentosa, is a component of the Golgi-centrosomal network.
New
Rivolta et al., Lausanne, Switzerland. In Hum Mol Genet, Jul 2015
Notable FAM161A interactors included AKAP9, FIP3, GOLGA3, KIFC3, KLC2, PDE4DIP, NIN and TRIP11.
High expression of kinesin light chain-2, a novel target of miR-125b, is associated with poor clinical outcome of elderly non-small-cell lung cancer patients.
New
Chen et al., Guangzhou, China. In Br J Cancer, Apr 2015
This study is to identify the function of KLC2 and its interaction with miR-125b in NSCLC.
Structural basis for kinesin-1:cargo recognition.
Impact
Dodding et al., London, United Kingdom. In Science, 2013
Here, we present the crystal structure of the tetratricopeptide repeat domain of kinesin light chain 2 in complex with a cargo peptide harboring a "tryptophan-acidic" motif derived from SKIP (SifA-kinesin interacting protein), a critical host determinant in Salmonella pathogenesis and a regulator of lysosomal positioning.
Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo.
Miller et al., London, United Kingdom. In Oncogene, 2012
Here, we show that LMTK2 regulates a known pathway that controls phosphorylation of kinesin-1 light chain-2 (KLC2) by glycogen synthase kinase-3β (GSK3β).
Identification of early zygotic genes in the yellow fever mosquito Aedes aegypti and discovery of a motif involved in early zygotic genome activation.
Tu et al., Blacksburg, United States. In Plos One, 2011
A 38 bp sequence in the proximal upstream sequence of a kinesin light chain EZG (KLC2.1)
Crystal structures of the tetratricopeptide repeat domains of kinesin light chains: insight into cargo recognition mechanisms.
GeneRIF
Park et al., Toronto, Canada. In Plos One, 2011
For the binding of cargos shared by KLC2, we propose a different site located within the groove but not involving N343.
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.
Way et al., London, United Kingdom. In Embo J, 2011
These proteins interact with the kinesin light chain outside the context of infection and have distinct preferences for KLC1 and KLC2.
A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors.
GeneRIF
Manji et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2010
KLC2 is a cellular target of GSK-3beta capable of regulating synaptic plasticity, particularly AMPA receptor trafficking, as well as mood-associated behaviors in animal models
Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.
GeneRIF
Sznajder et al., Chicago, United States. In Faseb J, 2010
Na,K-ATPase traffic toward the plasma membrane in alveolar epithelial cells is driven by kinesin-1, where KLC2 is the isoform regulating this process.
Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export.
Smith et al., London, United Kingdom. In Plos Pathog, 2010
Moreover, molecular modeling of F12 TPRs upon the crystal structure of KLC2 TPRs showed a striking conservation of structure.
UNC-83 is a nuclear-specific cargo adaptor for kinesin-1-mediated nuclear migration.
Starr et al., Davis, United States. In Development, 2009
Here, we show that UNC-83 also interacts with the kinesin-1 light chain KLC-2, as identified in a yeast two-hybrid screen and confirmed by in vitro assays.
Uropathogenic Escherichia coli invades host cells via an HDAC6-modulated microtubule-dependent pathway.
Mulvey et al., Salt Lake City, United States. In J Biol Chem, 2009
Invasion did not require two alternate HDAC6 substrates, Hsp90 and cortactin, but was dependent upon the kinesin-1 light chain KLC2 and an upstream activator of HDAC6, aurora A kinase.
Conventional kinesin holoenzymes are composed of heavy and light chain homodimers.
Morfini et al., Chicago, United States. In Biochemistry, 2008
The products of three kinesin-1 (kinesin-1A, -1B, and -1C, formerly KIF5A, -B, and -C) and two KLC (KLC1, KLC2) genes are expressed in mammalian nervous tissue, but the functional significance of this subunit heterogeneity remains unknown.
Insulin-induced GLUT4 movements in C2C12 myoblasts: evidence against a role of conventional kinesin motor proteins.
Kasuga et al., Kōbe, Japan. In Kobe J Med Sci, 2007
In these cells, overexpression of either wild-type kinesin light chain 2 (KLC2) or its phosphorylation-defective mutant did not significantly affect insulin-stimulated translocation of exofacial Myc-tagged GLUT4-green fluorescent protein to the cell surface and its subsequent externalization.
Rat kinesin light chain 3 associates with spermatid mitochondria.
GeneRIF
van der Hoorn et al., Calgary, Canada. In Dev Biol, 2004
Rat KHC3 associates with mitochondria in sperm tails
Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.
GeneRIF
van der Hoorn et al., Calgary, Canada. In J Biol Chem, 2003
Rat KLC3 associates with the outer dense fibers of maturing sperm tails.
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