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KiSS-1 metastasis-suppressor

kisspeptin, Kiss1, metastin, kisspeptin-10
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: Gonadotropin-Releasing Hormone, V1a, HAD, CAN, Neuropeptide
Papers using kisspeptin antibodies
Epigenetic and proteolytic inactivation of 14-3-3sigma in breast and prostate cancers.
Supplier
Koch Karl-Wilhelm, In PLoS ONE, 2005
... Kisspeptin-10 was purchased from Phoenix Pharmaceuticals (Burlingame, CA) ...
KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Bα-induced block of p65/p50 nuclear translocation
Supplier
Williams Paula Juliet et al., In The Journal of Endocrinology, 2000
... Slides were then incubated for 1 h with appropriate mouse monoclonal antibody for either KISS1 (AbD Serotec, Oxford, UK; MCA3219Z; 1:50) ...
Papers on kisspeptin
Divergent regulation of ER and Kiss genes by 17β-estradiol in hypothalamic ARC versus AVPV models.
New
Belsham et al., Toronto, Canada. In Mol Endocrinol, Feb 2016
UNASSIGNED: Kisspeptin (Kiss) and Gpr54 have emerged as key regulators of reproduction.
Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function.
New
Power et al., Faro, Portugal. In Mar Genomics, Jan 2016
UNASSIGNED: Allatostatin-type A (AST-A), kisspeptin (KISS) and galanin (GAL) G-protein coupled receptor (GPCR) systems share a common ancestral origin in arthropods and the vertebrates where they regulate metabolism and reproduction.
KISS1R signaling promotes invadopodia formation in human breast cancer cell via β-arrestin2/ERK.
New
Bhattacharya et al., London, Canada. In Cell Signal, Jan 2016
UNASSIGNED: Kisspeptins (KPs), peptide products of the KISS1 gene are endogenous ligands for the kisspeptin receptor (KISS1R), a G protein-coupled receptor.
Ghrelin action on GnRH neurons and pituitary gonadotropes might be mediated by GnIH-GPR147 system.
Review
New
Celik et al., In Horm Mol Biol Clin Investig, Jan 2016
The GnIH-GPR147 system receives information regarding the status of energy reservoir of body from circulating peptides and then transfers them to the kisspeptin-GnIH-GnRH network.
Therapeutic Neuroendocrine Agonist and Antagonist Analogs of Hypothalamic Neuropeptides as Modulators of the Hypothalamic-Pituitary-Gonadal Axis.
Review
New
Millar et al., In Endocr Dev, Dec 2015
The novel neuroendocrine peptides, kisspeptin (KP) and neurokinin B (NKB), were recently discovered as upstream regulators of GnRH, and inactivating mutations of KP and NKB ligands or receptors result in a failure to progress through puberty.
Different Medications for Hypogonadotropic Hypogonadism.
Review
New
Maggi et al., In Endocr Dev, Dec 2015
Other molecules, such as kisspeptin and neurokinin B agonists, are now under evaluation as new therapeutic options for treating DP.
Contemporary Trends in Onset and Completion of Puberty, Gain in Height and Adiposity.
Review
New
Kiess et al., In Endocr Dev, Dec 2015
The relationship of BMI and onset of puberty may be mediated by several factors, including leptin and kisspeptin, changes in bioavailable sex hormones, and environmental exposures.
Kisspeptin signalling and its roles in humans.
Review
New
Tng, Singapore, Singapore. In Singapore Med J, Dec 2015
Kisspeptins are a group of peptide fragments encoded by the KISS1 gene in humans.
Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
New
Tena-Sempere et al., Córdoba, Spain. In Sci Rep, Dec 2015
Gpr54(-/-)Tg rescued mice showed also altered gonadotropin responses to negative feedback withdrawal, while luteinizing hormone responses to various gonadotropic regulators were variably affected, with partially blunted relative (but not absolute) responses to kisspeptin-10, NMDA and the agonist of tachykinin receptors, NK2R.
Lateral ventricle injection of orexin-A ameliorates central precocious puberty in rat via inhibiting the expression of MEG3.
Guo et al., Yangzhou, China. In Int J Clin Exp Pathol, 2014
qRT-PCR was performed to examine the expression of MEG3 and kisspeptin in rats.
Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels.
Impact
Kelly et al., Portland, United States. In Cell Metab, 2014
Using whole-cell recording and selective pharmacological tools, we have found that, similar to leptin, purified insulin depolarized POMC and adjacent kisspeptin neurons via activation of TRPC5 channels, which are highly expressed in these neurons.
Glucagon regulates hepatic kisspeptin to impair insulin secretion.
Impact
Hussain et al., Baltimore, United States. In Cell Metab, 2014
Synthetic kisspeptin suppresses GSIS in vivo in mice and from isolated islets in a kisspeptin1 receptor-dependent manner.
FGF21 contributes to neuroendocrine control of female reproduction.
Impact
Mangelsdorf et al., Dallas, United States. In Nat Med, 2013
Mechanistically, FGF21 acts on the suprachiasmatic nucleus (SCN) in the hypothalamus to suppress the vasopressin-kisspeptin signaling cascade, thereby inhibiting the proestrus surge in luteinizing hormone.
High-fat diet increases LH pulse frequency and kisspeptin-neurokinin B expression in puberty-advanced female rats.
GeneRIF
O'Byrne et al., London, United Kingdom. In Endocrinology, 2012
Data suggest that the earlier accelerated GnRH pulse generator frequency and advanced puberty with obesogenic diets might be associated with premature up-regulation of kisspeptin and NKB signaling in the hypothalamus of the female rat.
Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons.
GeneRIF
Chen et al., Fuzhou, China. In J Endocrinol, 2012
Adiponectin reduces Kiss1 gene transcription in GT1-7 cells through activation of AMPK and subsequently decreased translocation of SP1.
Kisspeptins and reproduction: physiological roles and regulatory mechanisms.
Review
Impact
Tena-Sempere et al., Córdoba, Spain. In Physiol Rev, 2012
Compelling evidence, accumulated in the last few years, has revealed that kisspeptins, a family of neuropeptides encoded by the Kiss1 gene and produced mainly by neuronal clusters at discrete hypothalamic nuclei, are pivotal upstream regulators of GnRH neurons.
Plasma kisspeptin levels in girls with premature thelarche.
GeneRIF
Ilhan et al., Malatya, Turkey. In J Clin Res Pediatr Endocrinol, 2012
Data show that plasma kisspeptin levels were higher in patients with premature thelarche (PT).
KISS-1 inhibits the proliferation and invasion of gastric carcinoma cells.
GeneRIF
He et al., Xinxiang, China. In World J Gastroenterol, 2012
KISS-1 may inhibit the proliferation and invasion of gastric carcinoma cells in vitro and in vivo through the downregulation of MMP-9
Inactivating KISS1 mutation and hypogonadotropic hypogonadism.
Impact
GeneRIF
Yuksel et al., Adana, Turkey. In N Engl J Med, 2012
We describe an inactivating mutation in KISS1 in a large consanguineous family that results in failure of pubertal progression, indicating that functional kisspeptin is important for puberty and reproduction in humans.
Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression.
GeneRIF
Kandemir et al., Ankara, Turkey. In J Pediatr Endocrinol Metab, 2011
High KISS1 is associated with central precocious puberty.
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