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KiSS-1 metastasis-suppressor

kisspeptin, Kiss1, metastin, kisspeptin-10
This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: Gonadotropin-Releasing Hormone, V1a, HAD, CAN, Neuropeptide
Papers using kisspeptin antibodies
Epigenetic and proteolytic inactivation of 14-3-3sigma in breast and prostate cancers.
Koch Karl-Wilhelm, In PLoS ONE, 2005
... Kisspeptin-10 was purchased from Phoenix Pharmaceuticals (Burlingame, CA) ...
KiSS-1 represses 92-kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of Ikappa Bα-induced block of p65/p50 nuclear translocation
Williams Paula Juliet et al., In The Journal of Endocrinology, 2000
... Slides were then incubated for 1 h with appropriate mouse monoclonal antibody for either KISS1 (AbD Serotec, Oxford, UK; MCA3219Z; 1:50) ...
Papers on kisspeptin
Divergent regulation of ER and Kiss genes by 17β-estradiol in hypothalamic ARC versus AVPV models.
Belsham et al., Toronto, Canada. In Mol Endocrinol, Feb 2016
UNASSIGNED: Kisspeptin (Kiss) and Gpr54 have emerged as key regulators of reproduction.
Allatostatin-type A, kisspeptin and galanin GPCRs and putative ligands as candidate regulatory factors of mantle function.
Power et al., Faro, Portugal. In Mar Genomics, Jan 2016
UNASSIGNED: Allatostatin-type A (AST-A), kisspeptin (KISS) and galanin (GAL) G-protein coupled receptor (GPCR) systems share a common ancestral origin in arthropods and the vertebrates where they regulate metabolism and reproduction.
KISS1R signaling promotes invadopodia formation in human breast cancer cell via β-arrestin2/ERK.
Bhattacharya et al., London, Canada. In Cell Signal, Jan 2016
UNASSIGNED: Kisspeptins (KPs), peptide products of the KISS1 gene are endogenous ligands for the kisspeptin receptor (KISS1R), a G protein-coupled receptor.
Contemporary Trends in Onset and Completion of Puberty, Gain in Height and Adiposity.
Kiess et al., In Endocr Dev, Dec 2015
The relationship of BMI and onset of puberty may be mediated by several factors, including leptin and kisspeptin, changes in bioavailable sex hormones, and environmental exposures.
Sexual Precocity - Genetic Bases of Central Precocious Puberty and Autonomous Gonadal Activation.
Latronico et al., In Endocr Dev, Dec 2015
More recently, dominant activating and inactivating mutations of excitatory (KISS1/KISS1R) and inhibitory (MKRN3) modulators of gonadotropin-releasing hormone secretion, respectively, were associated with central precocious puberty phenotype.
Genetics of Hypogonadotropic Hypogonadism.
Kotan et al., In Endocr Dev, Dec 2015
Also, discovery of mutations in KISS1/KISS1R and TAC3/TACR3 in kisspeptin and neurokinin B signaling, respectively, has provided major advancements in our understanding of the biology of the gonadotropin-releasing hormone pulse generator.
The Emerging Role of Epigenetics in the Regulation of Female Puberty.
Ojeda et al., In Endocr Dev, Dec 2015
PcG proteins prevent the premature initiation of female puberty by silencing the Kiss1 gene in kisspeptin neurons of the arcuate nucleus (ARC) of the hypothalamus.
Kisspeptin signalling and its roles in humans.
Tng, Singapore, Singapore. In Singapore Med J, Dec 2015
Kisspeptins are a group of peptide fragments encoded by the KISS1 gene in humans.
Direct Actions of Kisspeptins on GnRH Neurons Permit Attainment of Fertility but are Insufficient to Fully Preserve Gonadotropic Axis Activity.
Tena-Sempere et al., Córdoba, Spain. In Sci Rep, Dec 2015
Gpr54(-/-)Tg rescued mice showed also altered gonadotropin responses to negative feedback withdrawal, while luteinizing hormone responses to various gonadotropic regulators were variably affected, with partially blunted relative (but not absolute) responses to kisspeptin-10, NMDA and the agonist of tachykinin receptors, NK2R.
Lateral ventricle injection of orexin-A ameliorates central precocious puberty in rat via inhibiting the expression of MEG3.
Guo et al., Yangzhou, China. In Int J Clin Exp Pathol, 2014
qRT-PCR was performed to examine the expression of MEG3 and kisspeptin in rats.
Insulin excites anorexigenic proopiomelanocortin neurons via activation of canonical transient receptor potential channels.
Kelly et al., Portland, United States. In Cell Metab, 2014
Using whole-cell recording and selective pharmacological tools, we have found that, similar to leptin, purified insulin depolarized POMC and adjacent kisspeptin neurons via activation of TRPC5 channels, which are highly expressed in these neurons.
Glucagon regulates hepatic kisspeptin to impair insulin secretion.
Hussain et al., Baltimore, United States. In Cell Metab, 2014
Synthetic kisspeptin suppresses GSIS in vivo in mice and from isolated islets in a kisspeptin1 receptor-dependent manner.
FGF21 contributes to neuroendocrine control of female reproduction.
Mangelsdorf et al., Dallas, United States. In Nat Med, 2013
Mechanistically, FGF21 acts on the suprachiasmatic nucleus (SCN) in the hypothalamus to suppress the vasopressin-kisspeptin signaling cascade, thereby inhibiting the proestrus surge in luteinizing hormone.
High-fat diet increases LH pulse frequency and kisspeptin-neurokinin B expression in puberty-advanced female rats.
O'Byrne et al., London, United Kingdom. In Endocrinology, 2012
Data suggest that the earlier accelerated GnRH pulse generator frequency and advanced puberty with obesogenic diets might be associated with premature up-regulation of kisspeptin and NKB signaling in the hypothalamus of the female rat.
Adiponectin inhibits KISS1 gene transcription through AMPK and specificity protein-1 in the hypothalamic GT1-7 neurons.
Chen et al., Fuzhou, China. In J Endocrinol, 2012
Adiponectin reduces Kiss1 gene transcription in GT1-7 cells through activation of AMPK and subsequently decreased translocation of SP1.
Kisspeptins and reproduction: physiological roles and regulatory mechanisms.
Tena-Sempere et al., Córdoba, Spain. In Physiol Rev, 2012
Compelling evidence, accumulated in the last few years, has revealed that kisspeptins, a family of neuropeptides encoded by the Kiss1 gene and produced mainly by neuronal clusters at discrete hypothalamic nuclei, are pivotal upstream regulators of GnRH neurons.
Plasma kisspeptin levels in girls with premature thelarche.
Ilhan et al., Malatya, Turkey. In J Clin Res Pediatr Endocrinol, 2012
Data show that plasma kisspeptin levels were higher in patients with premature thelarche (PT).
KISS-1 inhibits the proliferation and invasion of gastric carcinoma cells.
He et al., Xinxiang, China. In World J Gastroenterol, 2012
KISS-1 may inhibit the proliferation and invasion of gastric carcinoma cells in vitro and in vivo through the downregulation of MMP-9
Inactivating KISS1 mutation and hypogonadotropic hypogonadism.
Yuksel et al., Adana, Turkey. In N Engl J Med, 2012
We describe an inactivating mutation in KISS1 in a large consanguineous family that results in failure of pubertal progression, indicating that functional kisspeptin is important for puberty and reproduction in humans.
Evaluation of serum kisspeptin levels in girls in the diagnosis of central precocious puberty and in the assessment of pubertal suppression.
Kandemir et al., Ankara, Turkey. In J Pediatr Endocrinol Metab, 2011
High KISS1 is associated with central precocious puberty.
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