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Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: KIR, KIR2DL1, KIR2DS4, p58, KIR2DL2
Papers on KIR2DL5
Pilot Study of Natural Killer Cells in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Multiple Sclerosis.
Marshall-Gradisnik et al., Griffith, Australia. In Scand J Immunol, Jan 2016
In the MS cohort, KIR2DL5 was significantly increased on CD56(bright) CD16(+/-) NK cells and expression of CD94 was significantly increased on CD56(dim) CD16(+) NK cells in comparison with the controls.
Natural killer cell killer immunoglobulin-like gene receptor polymorphisms in non-Hodgkin lymphoma: possible association with clinical course.
Pamuk et al., Edirne, Turkey. In Leuk Lymphoma, Oct 2015
Patients with early-stage NHL had more frequent KIR2DL5 and KIR2DL5B than patients with advanced-stage NHL.
The structure of the atypical killer cell immunoglobulin-like receptor, KIR2DL4.
Vivian et al., Australia. In J Biol Chem, May 2015
KIR2DL4 is distinct from other KIRs (except KIR2DL5) in that it does not contain a D1 domain and instead has a D0-D2 arrangement.
NK cell genotype and phenotype at diagnosis of acute lymphoblastic leukemia correlate with postinduction residual disease.
Leung et al., Memphis, United States. In Clin Cancer Res, 2015
MRD-positive patients were more likely to have KIR2DL5A (P = 0.006) and expressed less activating receptor NKp46 and FASL on their NK cells (P = 0.0074 and P = 0.029, respectively).
Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients.
Young et al., Aberdeen, United Kingdom. In Genes Immun, 2014
These genetic factors were associated with resistance to HCMV infection in a second cohort (n=65), where the Tel B genes KIR2DL5, -2DS1, 2DS5 and -3DS1 were all significantly associated with high viral loads.
Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).
Marshall-Gradisnik et al., Gold Coast, Australia. In Bmc Immunol, 2014
Moderate CFS/ME patients had increased CD8(+) CD45RA effector memory T cells, SLAM expression on NK cells, KIR2DL5(+) on CD4(+)T cells and BTLA4(+) on CD4(+)T central memory cells.
Genetic diversity of the KIR/HLA system and susceptibility to hepatitis C virus-related diseases.
De Paoli et al., Pordenone, Italy. In Plos One, 2014
KIR2DL5 and KIR2DS4 variants were performed using PCR and GeneScan analysis.
Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis.
Mansouri et al., Yazd, Iran. In Plos One, 2014
KIR2DL5 removal from a full Inhibitory KIR haplotype converted the mild protection (OR = 0.56) to a powerful predisposition to RA (OR = 16.47).
Killer-cell immunoglobulin-like receptors and falciparum malaria in southwest Nigeria.
Omotade et al., Ibadan, Nigeria. In Hum Immunol, 2014
The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases.
A hybrid qPCR/SNP array approach allows cost efficient assessment of KIR gene copy numbers in large samples.
Wallace et al., Cambridge, United Kingdom. In Bmc Genomics, 2013
Five other KIR genes, KIR2DS4, KIR2DL3, KIR2DL5, KIR2DS5 and KIR2DS1, in high linkage disequilibrium with KIR3DL1 and KIR3DS1, are also unlikely to be significantly associated.
Killer-cell Immunoglobulin-like Receptor gene linkage and copy number variation analysis by droplet digital PCR.
Traherne et al., Cambridge, United Kingdom. In Genome Med, 2013
Mendelian segregation of ddPCR-estimated KIR2DL5 CNVs was observed in Gambian families and CNV typing of other KIRs was shown to be accurate when compared to an established quantitative PCR method.
Influence of KIR genes and their HLA ligands in susceptibility to dengue in a population from southern Brazil.
Visentainer et al., Maringá, Brazil. In Tissue Antigens, 2013
P = 0.03) and KIR2DL5 (76.0%
Genetic diversity of the KIR/HLA system and outcome of patients with metastatic colorectal cancer treated with chemotherapy.
Toffoli et al., Pordenone, Italy. In Plos One, 2013
RESULTS: For CR, the presence of KIR2DL5A, 2DS5, 2DS1, 3DS1, and KIR3DS1/HLA-Bw4-I80 was associated with increased CR rates, with median ORs ranging from 2.1 to 4.3, while the absence of KIR2DS4 and 3DL1 was associated with increased CR rates (OR 3.1).
Distribution of KIR genes in Han population in Yunnan Province: comparison with other Han populations in China.
Yu et al., Kunming, China. In Int J Immunogenet, 2013
Our data showed that the inhibitory gene frequency of genes KIR2DL1, KIR2DL3, KIR3DL1, KIR2DL5 and KIR2DL2 was 0.930, 0.889, 0.789, 0.206 and 0.095, respectively, and the activating gene frequency of KIR2DS4, KIR3DS1, KIR2DS1, KIR2DS5, KIR2DS2 and KIR2DS3 was 0.795, 0.218, 0.196, 0.165, 0.095 and 0.087, respectively.
Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease.
Lee et al., Singapore, Singapore. In J Alzheimers Dis, 2012
We found statistically significant upregulation in KIR2DL5A, SLC2A8, and PLOD1 for fast- (n = 8) compared with slow-progressors (n = 21) across the time-points.
Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.
Noyola et al., San Luis Potosí, Mexico. In Immunogenetics, 2012
indicate that killer-cell immunoglobulin-like receptors (KIRs)activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5) genes are associated with severe pandemic influenza A (H1N1) 2009 infections.
Natural killer cell receptor and HLA-C gene polymorphisms among patients with hepatitis C: a comparison between sustained virological responders and non-responders.
Lyra et al., Salvador, Brazil. In Liver Int, 2010
KIR2DL5 is a candidate gene involved in immunomodulation associated with non-response to antiviral therapy.
Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.
Middleton et al., Belfast, United Kingdom. In Tissue Antigens, 2008
Alleles commonly found in a Northern Irish population of 354 individuals were KIR2DL5A*001, KIR2DL5A*005, and KIR2DL5B*002.
KIR2DL5 alleles mark certain combination of activating KIR genes.
Rajalingam et al., Los Angeles, United States. In Genes Immun, 2008
The nature of KIR2DL5 gene polymorphism into four ethnic groups using direct DNA sequencing method was elucidated.
Promoter variants of KIR2DL5 add to diversity and may impact gene expression.
Hurley et al., Washington, D.C., United States. In Immunogenetics, 2008
Promoter variants of KIR2DL5 add to diversity and may impact gene expression.
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