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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1

KIR2DL1, KIR2DL4, CD158a, p58.1
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: KIR, p58, KIR2DL2, HAD, CD94
Papers on KIR2DL1
Characterization of KIR intermediate promoters reveals four promoter types associated with distinct expression patterns of KIR subtypes.
Anderson et al., Frederick, United States. In Genes Immun, Jan 2016
The recent identification of an intermediate KIR promoter (ProI) associated with KIR2DL1 expression suggested a central role for this element in KIR expression.
Functional advantage of educated KIR2DL1(+) natural killer cells for anti-HIV-1 antibody-dependent activation.
Parsons et al., Melbourne, Australia. In Clin Exp Immunol, Jan 2016
In the present study we assessed the ability of the KIR2DL1/HLA-C2 receptor/ligand combination to confer enhanced activation upon direct stimulation with HLA-I-devoid target cells or antibody-dependent stimulation with HIV-1 gp140-pulsed CEM.NKr-CCR5 target cells in the presence of an anti-HIV-1 antibody source.
Phenotype of NK Cells Determined on the Basis of Selected Immunological Parameters in Children Treated due to Acute Lymphoblastic Leukemia.
Grzesk et al., Toruń, Poland. In Medicine (baltimore), Dec 2015
The fraction of NK cells expressing CD158a, CD158b, perforin, A, B, and K granzymes was examined in isolated NK cells.We have shown that patients assessed at ALL diagnosis showed significantly lower values of the fraction of NK cells and percentage of NK cells with the granzyme A expression.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
We aimed to compare intrahepatic and blood NK cell receptor expression to determine the existence of CD49a+ and CXCR6+ NK cells in human liver and define the maturation status of NKG2C+ NK cells at this site.
NK Cell Subgroups, Phenotype, and Functions After Autologous Stem Cell Transplantation.
Ullrich et al., Oslo, Norway. In Front Immunol, 2014
Moreover, these NK cells strongly upregulated KIR2DL2/3/S2 and KIR3DL1, whereas KIR2DL1/S1 remained constant, indicating that this cell population arose from more immature NK cells instead of from activated mature ones.
Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis.
Mansouri et al., Yazd, Iran. In Plos One, 2014
Inhibitory haplotype No. 7 comprising KIR2DL5 in the absence of KIR2DL1 and KIR2DL3 confers a 14-fold protective effect against RA.
HLA-G-mediated NK cell senescence promotes vascular remodeling: implications for reproduction.
Rajagopalan, In Cell Mol Immunol, 2014
This review will cover the role of KIR at the maternal/fetal interface and focus on KIR2DL4, a KIR family member that is uniquely poised to play a role in pregnancy due to the restricted expression of its ligand, human leukocyte antigen (HLA)-G, by fetal trophoblast cells early in pregnancy.
Effect of donor KIR2DL1 allelic polymorphism on the outcome of pediatric allogeneic hematopoietic stem-cell transplantation.
Leung et al., Memphis, United States. In J Clin Oncol, 2013
Some KIR2DL1 alleles encode receptors that have stronger signaling function than others.
Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions.
Lutz et al., Lexington, United States. In J Immunol, 2012
Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions.
Distinct distribution of killer-cell immunoglobulin-like receptor genes in the Mugil and Ilaita areas of Papua New Guinea.
Witt et al., Perth, Australia. In Tissue Antigens, 2012
Significant differences in the frequency of KIR genes were found between the two populations despite being separated by only 300 km
Investigation of NK cell function and their modulation in different malignancies.
Spuzic et al., Belgrade, Serbia. In Immunol Res, 2012
In our more recent studies, we give data of NK function and novel families of NK cell receptor expression in healthy individuals that may be of help in NK cell profiling, by giving referent values of basic and cytokine-induced expression of some NK cell receptors either in evaluation of disease or in immuno-monitoring during cytokine therapy of patients with malignancies.
NK-cells have an impaired response to acute exercise and a lower expression of the inhibitory receptors KLRG1 and CD158a in humans with latent cytomegalovirus infection.
Simpson et al., Houston, United States. In Brain Behav Immun, 2012
cytomegalovirus positive had lower proportions of NK-cells expressing inhibitory receptors (KLRG1 and CD158a)
The chicken leukocyte receptor cluster.
Göbel et al., München, Germany. In Vet Immunol Immunopathol, 2011
Comparisons of various features such as amino acid motifs, genomic structure, expression and associated adaptor molecules reveal the homology of CHIR to both the killer Ig-like and the leukocyte Ig-like receptor families, with most pronounced correlation of certain CHIR to the NK cell receptor KIR2DL4.
The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans.
Hurley et al., Rockville, United States. In Immunogenetics, 2011
The frequencies of alleles of killer cell immunoglobulin-like receptor genes, KIR3DL3 and KIR3DL2, and the carrier frequency of KIR2DL4 alleles have been determined from a population of African Americans by DNA sequencing of the coding regions.
Lack of KIR2DL4 gene in a fertile Caucasian woman.
Kuśnierczyk et al., Wrocław, Poland. In Tissue Antigens, 2011
KIR2DL4 gene may not be essential for fertility, as shown in a fertile Caucasian woman missing KIR2DL4 [case report]
Endosomal signaling and a novel pathway defined by the natural killer receptor KIR2DL4 (CD158d).
Rajagopalan, Rockville, United States. In Traffic, 2010
The NK cell receptor KIR2DL4 (CD158d) utilizes a new mode of endosomal signaling after binding its ligand, soluble HLA-G, in the extracellular milieu.
An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.
Ge et al., Shanghai, China. In Nat Immunol, 2008
Here we show that the association of KIR2DL1, an inhibitory receptor of NK cells, with beta-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated 'downstream' inhibitory signaling.
Structural studies on HLA-G: implications for ligand and receptor binding.
Rossjohn et al., Australia. In Hum Immunol, 2007
The relative orientation of the HLA-G protomers in the dimer structure suggests that it is unlikely that dimerization is involved in killer immunoglobulinlike receptor 2DL4 (KIR2DL4) binding.
CD8+ T cells in cutaneous T-cell lymphoma: expression of cytotoxic proteins, Fas Ligand, and killing inhibitory receptors and their relationship with clinical behavior.
Willemze et al., Amsterdam, Netherlands. In J Clin Oncol, 2002
PATIENTS AND METHODS: Immunohistochemical stainings for CD8, granzyme B (GrB), T cell-restricted intracellular antigen (TIA-1), Fas ligand (FasL), and killer-cell inhibitory receptors (KIRs; CD95, CD158a, and CD158b) were performed on 83 first-diagnostic biopsy samples obtained from patients with plaque-stage MF (n = 42), tumor-stage MF (n = 20), and CD30- PCLTCL (n = 21).
Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.
Wiley et al., Cambridge, United States. In Nat Immunol, 2001
We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to its class I MHC ligand, HLA-Cw4.
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