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Potassium inwardly-rectifying channel, subfamily J, member 4

Kir2.3, IRK3, KCNJ4
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Kir2.1, KIR, HAD, ROMK, CAN
Papers using Kir2.3 antibodies
Profiling diverse compounds by flux- and electrophysiology-based primary screens for inhibition of human Ether-a-go-go related gene potassium channels
Denton Jerod S. et al., In Frontiers in Pharmacology, 2009
Kir3.4 (NM_000890.3), and Kir2.3 (NM_152868) were purchased from OriGene Technologies (Rockville, MD, USA) ...
Papers on Kir2.3
Nav1.5 N-Terminal Domain Binding to α1-Syntrophin Increases Membrane Density of Human Kir2.1, Kir2.2 and Nav1.5 Channels.
Delpón et al., Madrid, Spain. In Cardiovasc Res, Feb 2016
reciprocal positive interactions depend on a specific C-terminal PDZ-binding domain sequence (SEI), which is present in Kir2.1 and Kir2.2 channels but not in Kir2.3.
Clinical Concentrations of Local Anesthetics Bupivacaine and Lidocaine Differentially Inhibit Human Kir2.x Inward Rectifier K+ Channels.
Ishihara et al., Saga, Japan. In Anesth Analg, Feb 2016
METHODS: This study used the patch-clamp technique to examine the effects of bupivacaine and lidocaine on Kir2.1, Kir2.2, and Kir2.3 channels expressed in human embryonic kidney 293 cells.
Regional variation of the inwardly rectifying potassium current in the canine heart and the contributions to differences in action potential repolarization.
Panama et al., Utica, United States. In J Mol Cell Cardiol, Jul 2015
Expression of Kir2.1 in the ventricle was 76.9-fold higher than that of atria and 5.8-fold higher than that of Purkinje, whereas the expression of Kir2.2 and Kir2.3 subunits was more evenly distributed in Purkinje and atria.
The inward rectifier potassium channel Kir2.1 is expressed in mouse neutrophils from bone marrow and liver.
Yellen et al., Boston, United States. In Am J Physiol Cell Physiol, Mar 2015
Kir2.3, and Kir2.4).
Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224.
Zitron et al., Heidelberg, Germany. In Naunyn Schmiedebergs Arch Pharmacol, 2014
Dronedarone inhibited Kir2.1 currents but had no effect on Kir2.2 or Kir2.3 currents.
Inward Rectifier K+ Currents Are Regulated by CaMKII in Endothelial Cells of Primarily Cultured Bovine Pulmonary Arteries.
Zhu et al., Daqing, China. In Plos One, 2014
Pharmacological analysis of the Kir currents demonstrated that insensitivity to intracellular ATP, pinacidil, glibenclamide, pH, GDP-β-S and choleratoxin suggested that currents weren't determined by KATP, Kir2.3, Kir2.4 and Kir3.x.
Diverse Kir expression contributes to distinct bimodal distribution of resting potentials and vasotone responses of arterioles.
Jiang et al., Portland, United States. In Plos One, 2014
5) Molecular works revealed strong Kir2.1 and Kir2.2 transcripts and Kir2.1 immunolabeling in all 3 vessels, while Kir2.3 and Kir2.4 transcript levels varied.
Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2.
Levitan et al., Chicago, United States. In Comput Struct Biotechnol J, 2014
Consistent with a reduction in PIP2 levels, dialysis of neomycin resulted in a decrease in Kir2.1 and Kir2.3 current amplitudes (current rundown), however, this effect was significantly delayed by cholesterol depletion for both types of channels suggesting that cholesterol depletion strengthens the interaction between Kir2 channels and PIP2.
Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels.
Kellendonk et al., New York City, United States. In J Neurosci, 2012
Increased excitability and decreased dendritic arborization are associated with downregulation of inward rectifier potassium channels (Kir2.1/2.3).
Molecular mechanism of inward rectifier potassium channel 2.3 regulation by tax-interacting protein-1.
Long et al., Tianjin, China. In J Mol Biol, 2009
TIP-1 may act as an important regulator for the endocytic pathway of Kir2.3.
Discovery of a small molecule inhibitor of ROMK and Kir7.1
Lindsley et al., Bethesda, United States. In Unknown Journal, 2009
Furthermore, at least 6 other members (Kir2.3,
Discovery of a small molecule inhibitor of ROMK with unprecedented selectivity
Lindsley et al., Bethesda, United States. In Unknown Journal, 2009
Furthermore, at least 6 other members (Kir2.3,
Mechanical deformation of ventricular myocytes modulates both TRPC6 and Kir2.3 channels.
Isenberg et al., Halle, Germany. In Cell Calcium, 2009
modulated by mechanical deformation of ventricular myocytes
Overexpression of Kir2.3 in PC12 cells resists rotenone-induced neurotoxicity associated with PKC signaling pathway.
Chen et al., Shanghai, China. In Biochem Biophys Res Commun, 2008
These studies provide an entry point for understanding the novel roles of Kir2.3 in cell models of PD, and they offer clues for the common mechanisms underlying different neurodegenerative conditions.
Kir2.3 knock-down decreases IK1 current in neonatal rat cardiomyocytes.
Chen et al., Shanghai, China. In Febs Lett, 2008
The data suggest that Kir2.3 plays a potentially important role in I(K1) currents in neonatal rat cardiomyocytes.
An alternative approach to the identification of respiratory central chemoreceptors in the brainstem.
Wu et al., Atlanta, United States. In Respir Physiol, 2001
Among homomeric Kirs, we have found that even the most sensitive Kir1.1 and Kir2.3 have pK approximately 6.8, suggesting that they may not be capable of detecting hypocapnia.
Potassium channels of glial cells: distribution and function.
Horio, Sapporo, Japan. In Jpn J Pharmacol, 2001
Kir4.1 in retinal glial cells and Kir2.1, Kir2.3 and Kv1.5 in Schwann cells have been identified.
Regulation of IRK3 inward rectifier K+ channel by m1 acetylcholine receptor and intracellular magnesium.
Jan et al., San Francisco, United States. In Cell, 1997
We report that the IRK3 but not the IRK1 inward rectifier K+ channel activity is inhibited by m1 muscarinic acetylcholine receptor.
Regions responsible for the assembly of inwardly rectifying potassium channels.
Jan et al., San Francisco, United States. In Cell, 1996
We have used biochemical and electrophysiological methods to identify regions required for homotypic interactions and those responsible for the incompatibility between IRK1 and two other members of the same subfamily (IRK2 and IRK3) and two members from other subfamilies (ROMK1 and 6.1 uK(ATP)).
Inward rectifier potassium channels. Cloning, expression and structure-function studies.
Adelman et al., Portland, United States. In Jpn Heart J, 1996
When expressed in Xenopus oocytes, two of these clones (Kir4.1 and Kir2.3) gave rise to inwardly rectifying potassium currents.
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