Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2.
Chicago, United States. In Comput Struct Biotechnol J, 2014
Consistent with a reduction in PIP2 levels, dialysis of neomycin resulted in a decrease in Kir2.1 and Kir2.3 current amplitudes (current rundown), however, this effect was significantly delayed by cholesterol depletion for both types of channels suggesting that cholesterol depletion strengthens the interaction between Kir2 channels and PIP2.
Regions responsible for the assembly of inwardly rectifying potassium channels.
San Francisco, United States. In Cell, 1996
We have used biochemical and electrophysiological methods to identify regions required for homotypic interactions and those responsible for the incompatibility between IRK1 and two other members of the same subfamily (IRK2 and IRK3) and two members from other subfamilies (ROMK1 and 6.1 uK(ATP)).