Targeting renal epithelial channels for the control of insect vectors.
Ithaca, United States. In Tissue Barriers, Oct 2015
Three small molecules were identified in high throughput screens that 1) block renal inward rectifier potassium (Kir) channels of Aedes aegypti expressed in HEK cells and Xenopus oocytes, 2) inhibit the secretion of KCl but not NaCl in isolated Malpighian tubules, and after injection into the hemolymph, 3) inhibit KCl excretion in vivo, and 4) render mosquitoes flightless or dead within 24h.
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
Southampton, United Kingdom. In Lancet, Mar 2015
FINDINGS: Frequencies of NK cell precursors were similar in the liver and the blood (0·91% [0·62-3·26] vs 0·87 [0·41-1·52]); however, expression of all later markers of maturity were reduced including CD16 (47% [40·4-61·4] vs 88·7 [82·2-93·2], p<0·0001), CD57 (30·7% [25·0-53·9] vs 73·4 [70·4-87·6], p=0·0003), and KIR (11·2% [7·5-14·5] vs 26·7 [17·3-30·8], p<0·0001).
MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection.
Göttingen, Germany. In Front Immunol, 2014
The activity of these cells is regulated via interaction of specific and diverse killer cell immunoglobulin-like receptors (KIR) with the highly polymorphic cognate MHC class I proteins on target cells.
Structural Insights into GIRK Channel Function.
New York City, United States. In Int Rev Neurobiol, 2014
GIRK channels, like all other Kir channels, possess an extrinsic mechanism of inward rectification involving intracellular Mg(2+) and polyamines that occlude the conduction pathway at membrane potentials positive to E(K).