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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

GTP binding protein

KIR, GTP-Binding Protein, KIR3DL1
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, KIR2DL1, KIR2DL2
Papers on KIR
Skin Cancer Risk Is Modified by KIR/HLA Interactions That Influence the Activation of Natural Killer Immune Cells.
New
Nelson et al., Minneapolis, United States. In Cancer Res, Feb 2016
Natural killer (NK)-cell phenotype is partially mediated through binding of killer-cell immunoglobulin-like receptors (KIR) with HLA class I ligands.
EDH: Endothelium-dependent hyperpolarization and microvascular signaling.
Review
New
Dora et al., Oxford, United Kingdom. In Acta Physiol (oxf), Feb 2016
KC a activation hyperpolarizes endothelial cells, and K(+) efflux through them can act as a diffusible 'EDHF' by stimulating VSM Na(+) /K(+) -ATPase and inwardly-rectifying K-channels (KIR ).
Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.
New
Whiteheart et al., Lexington, United States. In Blood, Feb 2016
ADP-ribosylation factor 6 (Arf6) is a small GTP-binding protein known to regulate endocytic trafficking, especially of integrins.
[Analysis of KIR3DL1 expression levels on 92 cases of normal donors for hematopoietic stem cells transplant].
New
He et al., Suzhou, China. In Zhonghua Xue Ye Xue Za Zhi, Jan 2016
METHODS: Ninety- two donors were performed by using of KIR genotyping, HLA high resolution genotyping and KIR3DL1 expression level using sequencebased testing(SBT), PCR- sequence specific primer(SSP)and flow cytometry methods.
Guanylate-binding protein 1 (GBP1) promotes lymph node metastasis in human esophageal squamous cell carcinoma.
New
Liu et al., Beijing, China. In Discov Med, Dec 2015
Guanylate-binding protein 1 (GBP1) is a GTP-binding protein family member with high GTPase activity.
Exploring the Role of Killer Cell Immunoglobulin-Like Receptors and Their HLA Class I Ligands in Autoimmune Hepatitis.
New
Carcassi et al., Cagliari, Italy. In Plos One, Dec 2015
Additionally, the low frequency of the KIR-ligand combinations KIR3DL1/HLA-Bw4 and KIR2DL3/HLA-C1 coupled to the high frequency of the HLA-C2 high affinity ligands for KIR2DS1 could contribute to unwanted NK cell autoreactivity in AIH-1.
Targeting renal epithelial channels for the control of insect vectors.
Review
New
Denton et al., Ithaca, United States. In Tissue Barriers, Oct 2015
Three small molecules were identified in high throughput screens that 1) block renal inward rectifier potassium (Kir) channels of Aedes aegypti expressed in HEK cells and Xenopus oocytes, 2) inhibit the secretion of KCl but not NaCl in isolated Malpighian tubules, and after injection into the hemolymph, 3) inhibit KCl excretion in vivo, and 4) render mosquitoes flightless or dead within 24h.
[EAST/SeSAME syndrome and functional expression of inward rectifier potassium channel Kir4.1 in the inner ear].
Review
New
Zhao et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, Jul 2015
Inwardly rectifying potassium (Kir) channels exhibit an asymmetrical conductance at hyperpolarization (high conductance) compared to depolarization (low conductance).
Natural killer cell maturation markers in the human liver and expansion of an NKG2C+KIR+ population.
New
Impact
Khakoo et al., Southampton, United Kingdom. In Lancet, Mar 2015
FINDINGS: Frequencies of NK cell precursors were similar in the liver and the blood (0·91% [0·62-3·26] vs 0·87 [0·41-1·52]); however, expression of all later markers of maturity were reduced including CD16 (47% [40·4-61·4] vs 88·7 [82·2-93·2], p<0·0001), CD57 (30·7% [25·0-53·9] vs 73·4 [70·4-87·6], p=0·0003), and KIR (11·2% [7·5-14·5] vs 26·7 [17·3-30·8], p<0·0001).
Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.
Review
Impact
Niemeyer et al., Valdivia, Chile. In Physiol Rev, 2015
Here we review two groups of K(+) channels, pH-regulated K2P channels and the transport group of Kir channels.
MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection.
Review
Ansari et al., Göttingen, Germany. In Front Immunol, 2014
The activity of these cells is regulated via interaction of specific and diverse killer cell immunoglobulin-like receptors (KIR) with the highly polymorphic cognate MHC class I proteins on target cells.
Structural Insights into GIRK Channel Function.
Review
Slesinger et al., New York City, United States. In Int Rev Neurobiol, 2014
GIRK channels, like all other Kir channels, possess an extrinsic mechanism of inward rectification involving intracellular Mg(2+) and polyamines that occlude the conduction pathway at membrane potentials positive to E(K).
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton.
Impact
Montcouquiol et al., Bordeaux, France. In Nat Cell Biol, 2013
Here, we show that deletion of GTP-binding protein alpha-i subunit 3 (Gαi3) and mammalian Partner of inscuteable (mPins) disrupts the migration of the kinocilium at the surface of cochlear hair cells and affects hair bundle orientation and shape.
HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1.
Impact
Hsu et al., New York City, United States. In N Engl J Med, 2012
The activating killer-cell immunoglobulin-like receptor (KIR) 2DS1 has ligand specificity for HLA-C2 antigens and activates NK cells in an HLA-dependent manner.
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.
Impact
Pepperkok et al., Dublin, Ireland. In Nat Cell Biol, 2012
Network analyses revealed a so far unappreciated link between early secretory pathway function, small GTP-binding protein regulation, actin cytoskeleton organization and EGF-receptor-mediated signalling.
Molecular determinants of Gem protein inhibition of P/Q-type Ca2+ channels.
GeneRIF
Yang et al., New York City, United States. In J Biol Chem, 2012
Gem contains two candidate inhibitory sites, each capable of producing full inhibition of P/Q-type Ca(2+) channels.
Structural basis for homeodomain recognition by the cell-cycle regulator Geminin.
GeneRIF
Zhu et al., Hong Kong, Hong Kong. In Proc Natl Acad Sci U S A, 2012
The C-terminal residue Ser184 of Geminin can be phosphorylated by Casein kinase II, resulting in the enhanced binding to Hox and more potent inhibitory effect on Hox transcriptional activity.
Geminin overexpression induces mammary tumors via suppressing cytokinesis.
GeneRIF
Elshamy et al., Jackson, United States. In Oncotarget, 2011
geminin is a genuine oncogene that promotes cytokinesis failure and production of aneuploid, aggressive breast tumors when overexpressed
Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B.
Impact
GeneRIF
Rossjohn et al., Australia. In Nature, 2011
structure of a human KIR3DL1 receptor bound to HLA-B*5701 complexed with a self-peptide
KIR3DL1+HLA-B Bw4Ile80 and KIR2DS1+HLA-C2 combinations are both associated with ankylosing spondylitis in the Iranian population.
GeneRIF
Jalali et al., Tehrān, Iran. In Int J Immunogenet, 2011
In this study, KIR2DS1+HLA-C2 and KIR3DL1+HLA-B Bw4 Ile80 combinations were associated with the vulnerability to ankylosing spondylitis.
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