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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Kinesin family member 15

kinesin-like protein 2, Hklp2, NY-BR-62
Top mentioned proteins: Aurora, Eg5, V1a, CAN, STEP
Papers on kinesin-like protein 2
New MKLP-2 inhibitors in the paprotrain series: Design, synthesis and biological evaluations.
New
Guillou et al., Gif-sur-Yvette, France. In Bioorg Med Chem, Jan 2016
One recently identified novel potential cancer therapeutic target is the Mitotic kinesin-like protein 2 (MKLP-2), a member of the kinesin-6 family, which plays an essential role during cytokinesis.
TPX2 promotes migration and invasion of human breast cancer cells.
New
Zhang et al., Wuhan, China. In Asian Pac J Trop Med, Dec 2015
OBJECTIVE: To investigate the expression of targeting protein for Xenopus kinesin-like protein 2 (TPX2) in breast cancer tissue and to explore its role in proliferation, migration and invasion of breast cancer cells.
TPX2 as a novel prognostic biomarker for hepatocellular carcinoma.
New
Liu et al., Xi'an, China. In Hepatol Res, Aug 2015
AIM: Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a microtubule-associated protein that impacts spindle assembly in human cells.
Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly.
New
Nguyen et al., Madrid, Spain. In J Biol Chem, May 2015
The human ortholog of the targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a cytoskeletal protein that plays a major role in spindle assembly and is required for mitosis.
Positive Surgical Margin, HPV Persistence, and Expression of Both TPX2 and PD-L1 Are Associated with Persistence/Recurrence of Cervical Intraepithelial Neoplasia after Cervical Conization.
Zhang et al., Jinan, China. In Plos One, 2014
These 100 cervical specimens were assessed for expression of insulin-like growth factor II messenger RNA (mRNA)-binding protein 3 (IMP3), targeting protein for xenopus kinesin-like protein 2 (TPX2), and programmed cell death-1 ligand-1 (PD-L1) using immunohistochemical staining.
TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts.
Heald et al., Berkeley, United States. In J Cell Biol, 2014
This suggested a role for the MT-associated protein TPX2 (targeting factor for Xenopus kinesin-like protein 2), which is regulated by Ran and binds Eg5.
TPX2 knockdown suppressed hepatocellular carcinoma cell invasion via inactivating AKT signaling and inhibiting MMP2 and MMP9 expression.
Liu et al., Xi'an, China. In Chin J Cancer Res, 2014
OBJECTIVE: Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a nuclear proliferation-related protein that plays a critical role in the formation of mitotic spindle.
TPX2 overexpression in medullary thyroid carcinoma mediates TT cell proliferation.
Shi et al., Tangshan, China. In Pathol Oncol Res, 2014
TPX2 (targeting protein for xenopus kinesin-like protein 2), a microtubule-associated protein, plays an important role in the formation of the mitotic spindle.
TPX2 regulates tumor growth in human cervical carcinoma cells.
Liu et al., Changchun, China. In Mol Med Report, 2014
The targeting protein for the Xenopus kinesin-like protein 2 (TPX2), a microtubule-associated protein, has been utilized as a tool to evaluate, more precisely, the proliferative behavior of tumor cells.
TPX2 is a prognostic marker and contributes to growth and metastasis of human hepatocellular carcinoma.
Kan et al., Guangzhou, China. In Int J Mol Sci, 2013
Targeting protein for Xenopus kinesin-like protein 2 (TPX2), a microtubule-associated protein, impacts spindle assembly in human cells.
Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.
Nguyen et al., Calgary, Canada. In J Biol Chem, 2013
The microtubule-associated protein targeting protein for Xenopus kinesin-like protein 2 (TPX2) plays a key role in spindle assembly and is required for mitosis in human cells.
MKlp2 inhibitor paprotrain affects polar body extrusion during mouse oocyte maturation.
Sun et al., Nanjing, China. In Reprod Biol Endocrinol, 2012
Numerous proteins contribute to these processes, but it is unknown whether MKlp2 (mitotic kinesin-like protein 2; also called KIF20A), a microtubule-associated protein that regulates cytokinesis during mitosis, is involved in oocyte maturation.
[Establishment of a targeting protein for Xenopus kinesin-like protein 2 C' terminal SBP-3 x Flag tagged HCT 116 colorectal cancer cell model].
Du et al., Beijing, China. In Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2011
OBJECTIVE: To develop a targeting protein for Xenopus kinesin-like protein 2 (TPX2) C' terminal SBP-3 x Flag-tagged HCT 116 cell model.
Modulated microtubule dynamics enable Hklp2/Kif15 to assemble bipolar spindles.
GeneRIF
Mayer et al., Konstanz, Germany. In Cell Cycle, 2011
Pole separation depends on Hklp2/Kif15, an otherwise dispensable plus end-directed spindle motor and results in spindles with two centrosomal poles.
Chromokinesins: localization-dependent functions and regulation during cell division.
Review
Vernos et al., Barcelona, Spain. In Biochem Soc Trans, 2011
More recently, we found that Hklp2/kif15 (kinesin 12) is targeted to the chromosomes through an interaction with Ki-67 in human cells and is therefore a novel chromokinesin.
Kif15 cooperates with eg5 to promote bipolar spindle assembly.
GeneRIF
Medema et al., Utrecht, Netherlands. In Curr Biol, 2009
Kif15 can replace all essential functions of Eg5 in bipolar spindle assembly.
The role of Hklp2 in the stabilization and maintenance of spindle bipolarity.
GeneRIF
Vernos et al., Barcelona, Spain. In Curr Biol, 2009
Hklp2 participates in the assembly and stabilization of the bipolar spindle.
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly.
Impact
Zheng et al., Baltimore, United States. In Nat Cell Biol, 2003
The activated form of Ran (Ran-GTP) stimulates spindle assembly in Xenopus laevis egg extracts, presumably by releasing spindle assembly factors, such as TPX2 (target protein for Xenopus kinesin-like protein 2) and NuMA (nuclear-mitotic apparatus protein) from the inhibitory binding of importin-alpha and -beta.
Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development.
GeneRIF
Baas et al., Philadelphia, United States. In J Neurocytol, 2003
Kif15 opposes the capacity of other motors to generate independent microtubule movements within key regions of developing neurons.
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