A unique kinesin-8 surface loop provides specificity for chromosome alignment.
Burlington, United States. In Mol Biol Cell, 2014
Kif18A (kinesin-8) localizes to the plus ends of the relatively slowly growing kinetochore fibers (K-fibers) and attenuates their dynamics, whereas Kif4A (kinesin-4) localizes to mitotic chromatin and suppresses the growth of highly dynamic, nonkinetochore microtubules.
The proliferation arrest of primary tumor cells out-of-niche is associated with widespread downregulation of mitotic and transcriptional genes.
In Hematology, 2014
MKI67, CCNB1, ASPM, SGOL1, DLGAP5, CENPF, BUB1, KIF23, KIF18a, KIF11, KIF14, KIF4, NUF2, KIF1, AE2FB, TOP2A, NCAPG, TTK, CDC20, and AURKB), which could account for the ensuing proliferation arrest.
Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistance.
Sacramento, United States. In Mol Cancer Res, 2014
Estrogen strongly induces expression of 19 kinesin genes such as Kif4A/4B, Kif5A/5B, Kif10, Kif11, Kif15, Kif18A/18B, Kif20A/20B, Kif21, Kif23, Kif24, Kif25, and KifC1, whereas suppresses the expression of seven others, including Kif1A, Kif1C, Kif7, and KifC3.
A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma.
London, United Kingdom. In Genome Med, 2013
Univariate assessment revealed higher expression of ITGA5, SEMA3A, KIF4A, IL20RB, SLC20A1, CDC45, PXN, SSX3 and TMEM26 was correlated with shorter survival while B3GNT1, NOSTRIN and CADPS down-regulation was associated with poor outcome.
When a motor goes bad: a kinesin regulates neuronal survival.
Toronto, Canada. In Cell, 2006
In this issue of Cell, Midorikawa et al. (2006) demonstrate that the kinesin superfamily member KIF4, a microtubule-based molecular motor, regulates the survival of electrically active neurons in the developing brain by modulating the function of poly(ADP-ribose) polymerase-1 in an unexpected way.