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Kinesin family member 4A

This gene encodes a member of the kinesin 4 subfamily of kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010] (from NCBI)
Papers on KIF4
KIF4 regulates midzone length during cytokinesis.
Mitchison et al., Boston, United States. In Curr Biol, 2011
KIF4 regulates midzone length during cytokinesis.
Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors.
Potter et al., Tampa, United States. In Cell Cycle, 2011
Abeta impairs the assembly and maintenance of the mitotic spindle. Mechanistically, these defects result from Abeta's inhibition of mitotic motor kinesins, including Eg5, KIF4A and MCAK.
Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo.
Zhu et al., Tianjin, China. In Tumour Biol, 2011
Loss of KIF4 expression is associated with gastric carcinoma.
KIF4 mediates anterograde translocation and positioning of ribosomal constituents to axons.
Cáceres et al., Córdoba, Argentina. In J Biol Chem, 2009
KIF4 is involved in the anterograde trafficking of ribosomal constituents to axons
Kinesin KIF4 regulates intracellular trafficking and stability of the human immunodeficiency virus type 1 Gag polyprotein.
Resh et al., New York City, United States. In J Virol, 2008
These studies identify a novel transit station through which Gag traffics en route to particle assembly and highlight the importance of KIF4 in regulating HIV-1 Gag trafficking and stability.
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