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Kinesin family member 3B

The protein encoded by this gene acts as a heterodimer with kinesin family member 3A to aid in chromosome movement during mitosis and meiosis. The encoded protein is a plus end-directed microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous organelles. This protein and kinesin family member 3A form the kinesin II subfamily of the kinesin superfamily. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: KIF3A, KIF3C, HAD, ACID, CAN
Papers on KIF3B
The heterotrimeric kinesin-2 complex interacts with and regulates GLI protein function.
Allen et al., Ann Arbor, United States. In J Cell Sci, Apr 2015
To examine a role for the heterotrimeric KIF3A-KIF3B-KAP3 kinesin-2 motor complex in regulating GLI activity, we performed a series of structure-function analyses using biochemical, cell signaling and in vivo approaches that define novel specific interactions between GLI proteins and two components of this complex, KAP3 and KIF3A.
Dual-trait selection for ethanol consumption and withdrawal: genetic and transcriptional network effects.
Hitzemann et al., Portland, United States. In Alcohol Clin Exp Res, 2014
QTLs overlapping with differentially expressed genes on Chr 2 (distal) and 4 suggest that these are cis-eQTLs (Chr 2: Kif3b, Kcnq2; Chr 4: Mpdz, Snapc3).
Kinesin-2 KIF3AB exhibits novel ATPase characteristics.
Gilbert et al., Troy, United States. In J Biol Chem, 2014
To define the ATPase mechanism and coordination of KIF3A and KIF3B stepping, a presteady-state kinetic analysis was pursued.
Flipping a phosphate switch on kinesin-II to turn IFT around.
Witman et al., Worcester, United States. In Dev Cell, 2014
(2014) report that IFT is regulated in part by the phosphorylation status of the kinesin-II subunit FLA8/KIF3B.
FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround.
Pan et al., Beijing, China. In Dev Cell, 2014
We show that the kinesin-II motor subunit FLA8, a homolog of KIF3B, is phosphorylated on the conserved S663 by a calcium-dependent kinase in Chlamydomonas.
Suppression of KIF3B expression inhibits human hepatocellular carcinoma proliferation.
Zhang et al., Nantong, China. In Dig Dis Sci, 2014
KIF3B, the kinesin superfamily of proteins (KIFs), plays an important role in the regulation of mitotic progression.
POPX2 phosphatase regulates the KIF3 kinesin motor complex.
Koh et al., Singapore, Singapore. In J Cell Sci, 2014
The kinesin-2 motor is a heterotrimeric complex composed of KIF3A, KIF3B motor subunits and KAP3, the non-motor subunit, which binds the cargo.
Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL.
Spits et al., Brussels, Belgium. In Mol Hum Reprod, 2014
The study of the mRNA gene expression levels of the loci located in the common region of duplication showed that HM13, ID1, BCL2L1, KIF3B and the immature form of the micro-RNA miR-1825 were up-regulated in mutant cells.
Regulation of cilium length and intraflagellar transport by the RCK-kinases ICK and MOK in renal epithelial cells.
Jansen et al., Rotterdam, Netherlands. In Plos One, 2013
To analyze the effects of ICK and MOK on the IFT machinery, we set up live imaging of five fluorescently tagged IFT proteins: KIF3B, a subunit of kinesin-II, the main anterograde IFT motor, complex A protein IFT43, complex B protein IFT20, BBSome protein BBS8 and homodimeric kinesin KIF17, whose function in mammalian cilia is unclear.
Functional Analysis of KIF3A and KIF3B during Spermiogenesis of Chinese Mitten Crab Eriocheir sinensis.
Yang et al., Hangzhou, China. In Plos One, 2013
KIF3A and KIF3B are believed to play some roles in the assembly and maintenance of flagella, intracellular transport of materials including organelles and proteins, and other unknown functions during this process.
Differential roles for 3-OSTs in the regulation of cilia length and motility.
Yost et al., Salt Lake City, United States. In Development, 2013
By contrast, a second 3-OST family member, 3-OST-6, does not regulate cilia length, but regulates cilia motility via kinesin motor molecule (Kif3b) expression and cilia arm dynein assembly.
Association of the testis-specific TRIM/RBCC protein RNF33/TRIM60 with the cytoplasmic motor proteins KIF3A and KIF3B.
Chang et al., Taipei, Taiwan. In Mol Cell Biochem, 2012
our data suggest that RNF33 most likely interacts with KIF3A-KIF3B independent of the adaptor kinesin-associated protein KAP3
Human kidney anion exchanger 1 interacts with kinesin family member 3B (KIF3B).
Yenchitsomanus et al., Bangkok, Thailand. In Biochem Biophys Res Commun, 2011
KIF3B is involved in the trafficking of kAE1 to the plasma membrane of human kidney alpha-intercalated cells.
Integrative genomic approaches in cervical cancer: implications for molecular pathogenesis.
Murty et al., New York City, United States. In Future Oncol, 2010
These analyses provide insights into the roles of genes such as RNASEN, POLS and SKP2 on 5p, KIF3B, RALY and E2F1 at 20q11.2 and CSE1L, ZNF313 and B4GALT5 at 20q13.13.
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.
Verhey et al., Ann Arbor, United States. In Nat Cell Biol, 2010
The biogenesis, maintenance and function of primary cilia are controlled through intraflagellar transport (IFT) driven by two kinesin-2 family members, the heterotrimeric KIF3A/KIF3B/KAP complex and the homodimeric KIF17 motor.
CLC-5 and KIF3B interact to facilitate CLC-5 plasma membrane expression, endocytosis, and microtubular transport: relevance to pathophysiology of Dent's disease.
Thakker et al., Oxford, United Kingdom. In Am J Physiol Renal Physiol, 2010
Interaction with KIF3B alters CLC-5 cell surface expression, chloride current, and alters albumin endocytosis. Interaction with KIF3B facilitates microtubular transport and endocytosis of CLC-5-containing vesicles away from cell surface.
Targeting of p0071 to the midbody depends on KIF3.
Hatzfeld et al., Halle, Germany. In J Cell Sci, 2009
Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis
The Rip11/Rab11-FIP5 and kinesin II complex regulates endocytic protein recycling.
Prekeris et al., Aurora, United States. In J Cell Sci, 2008
Rip11/FIP5-kinesin-II complex plays a key role in the routing of internalized receptors through the perinuclear recycling endosomes.
Identification of a link between the tumour suppressor APC and the kinesin superfamily.
Akiyama et al., Tokyo, Japan. In Nat Cell Biol, 2002
We show here that APC interacts with the kinesin superfamily (KIF) 3A-KIF3B proteins, microtubule plus-end-directed motor proteins, through an association with the kinesin superfamily-associated protein 3 (KAP3).
Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein.
Hirokawa et al., Tokyo, Japan. In Cell, 1999
Microtubule-dependent motor, murine KIF3B, was disrupted by gene targeting.
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