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Kinesin family member 12

Kif12, kinesin family member 12
KIF12 is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: CPK, SET, alpha1-microglobulin, MIPOL1, Irx2
Papers on Kif12
Copy number variation analysis identifies novel CAKUT candidate genes in children with a solitary functioning kidney.
Sanna-Cherchi et al., New York City, United States. In Kidney Int, Dec 2015
Among these genes, DLG1 and KIF12 are likely novel susceptibility genes for CAKUT in humans.
Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse.
Guay-Woodford et al., Birmingham, United States. In Plos One, 2014
One of them corresponds to the previously described positional Mpkd2 candidate gene, Kif12.
Antioxidant signaling involving the microtubule motor KIF12 is an intracellular target of nutrition excess in beta cells.
Hirokawa et al., Tokyo, Japan. In Dev Cell, 2014
Here, we demonstrate that the microtubule motor KIF12 mediates an antioxidant cascade in beta cells as an intracellular target of excess fat intake or "lipotoxicity."
Hypermethylation of EBF3 and IRX1 genes in synovial fibroblasts of patients with rheumatoid arthritis.
Kim et al., Taegu, South Korea. In Mol Cells, 2013
Thirteen genes (APEX1, EBF3, EGR2, EN1, IRX1, IRX6, KIF12, LHX2, MIPOL1, SGTA, SIN3A, TOLLIP, and ZHX2) with three consecutive hypermethylated probes were isolated as candidate genes through two CpG microarrays.
Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer.
Eng et al., Cleveland, United States. In Breast Cancer Res Treat, 2012
KIF12 is the most overexpressed KIF gene in post-chemotherapy taxane-resistant residual breast cancers (2.8-fold-change).
Systematic candidate gene investigations in the SPA2 locus (9q32) show an association between TNFSF8 and susceptibility to spondylarthritis.
Breban et al., Paris, France. In Arthritis Rheum, 2011
The coding regions, intron-exon boundaries, and 5'- and 3'-flanking regions of ZNF618, A1L4R1_HUMAN (AF495724), AMBP, KIF12, ORM1, ORM2, C9ORF91, ENSESTG000000230601, and TNFSF8 were resequenced to identify polymorphisms.
HNF-1beta regulates transcription of the PKD modifier gene Kif12.
Igarashi et al., Dallas, United States. In J Am Soc Nephrol, 2009
HNF-1beta regulates transcription of the PKD modifier gene Kif12.
Dictyostelium Aurora kinase has properties of both Aurora A and Aurora B kinases.
De Lozanne et al., Austin, United States. In Eukaryot Cell, 2008
This localization is dependent on DdINCENP and the motor proteins Kif12 and myosin II.
The localization of inner centromeric protein (INCENP) at the cleavage furrow is dependent on Kif12 and involves interactions of the N terminus of INCENP with the actin cytoskeleton.
De Lozanne et al., Austin, United States. In Mol Biol Cell, 2007
Here, we show that the association of Dictyostelium INCENP (DdINCENP) with the cortex of the cleavage furrow involves interactions with the actin cytoskeleton and depends on the presence of the kinesin-6-related protein Kif12.
Kinesin family member 12 is a candidate polycystic kidney disease modifier in the cpk mouse.
Guay-Woodford et al., Birmingham, United States. In J Am Soc Nephrol, 2005
Positional candidate gene, Kif12, fulfills the major criteria for quantitative trait loci gene discovery established by the Complex Trait Consortium, and, thus, it is proposed that Kif12 is a cpk modifier gene.
Characterization of KIF12 gene in silico.
Katoh et al., Japan. In Oncol Rep, 2005
Mouse Kif12 RefSeq (NM_010616.1)
A mitotic kinesin-like protein required for normal karyokinesis, myosin localization to the furrow, and cytokinesis in Dictyostelium.
Spudich et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2004
Dictyostelium mitotic kinesin Kif12 is required for cytokinesis.
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