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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PHD and ring finger domains 1

KIAA1542, PHRF1
Top mentioned proteins: STAT4, BANK, PXK, IRF-7, IRF5
Papers on KIAA1542
Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis.
New
Atfi et al., Paris, France. In Cell Rep, Mar 2015
UNASSIGNED: PHRF1 functions as an essential component of the TGF-β tumor suppressor pathway by triggering degradation of the homeodomain repressor factor TGIF.
PHRF1 promotes genome integrity by modulating non-homologous end-joining.
Chang et al., Taipei, Taiwan. In Cell Death Dis, 2014
Human PHRF1 contains a plant homeodomain (PHD) that recognizes methylated histones and a RING domain, which ubiquitinates substrates.
Immunochip identifies novel, and replicates known, genetic risk loci for rheumatoid arthritis in black South Africans.
Tikly et al., Johannesburg, South Africa. In Mol Med, 2013
Non-HLA single nucleotide polymorphisms (SNPs) in the intergenic regions LOC389203|RBPJ, LOC100131131|IL1R1, KIAA1919|REV3L, LOC643749|TRAF3IP2, and SNPs in the intron and untranslated regions (UTR) of IRF1 and the intronic region of ICOS and KIAA1542 showed association with RA (p < 5 × 10(-5)).
Identification of PHRF1 as a tumor suppressor that promotes the TGF-β cytostatic program through selective release of TGIF-driven PML inactivation.
Atfi et al., Paris, France. In Cell Rep, 2013
Here, we identify PHRF1 as a ubiquitin ligase that enforces TGIF decay by driving its ubiquitination at lysine 130.
Association of PHRF1-IRF7 region polymorphism with clinical manifestations of systemic lupus erythematosus in a Japanese population.
Tsuchiya et al., Tsukuba, Japan. In Lupus, 2012
Although recent studies detected association of a single nucleotide polymorphism (SNP) rs4963128 in PHD and ring finger domains 1 (PHRF1)/KIAA1542, located closely to IRF7, and IRF7 rs1131665 (glutamine (Gln) 412 arginine (Arg)) with systemic lupus erythematosus (SLE), causal variants have not been established.
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.
Sawalha et al., Oklahoma City, United States. In Ann Rheum Dis, 2012
The genetic effect observed in KIAA1542 is specific to women with SLE and does not seem to have a role in men.
Replication of GWAS-identified systemic lupus erythematosus susceptibility genes affirms B-cell receptor pathway signalling and strengthens the role of IRF5 in disease susceptibility in a Northern European population.
Review
Kere et al., Huddinge, Sweden. In Rheumatology (oxford), 2012
Association between SLE and TNFAIP3, FAM167A-BLK, BANK1 and KIAA1542 was also confirmed, although at a lower significance level and contribution to individual risk.
Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis.
Spanish Scleroderma Group et al., Granada, Spain. In Ann Rheum Dis, 2012
Five single nucleotide polymorphisms (SNPs) in the PHRF1-IRF7-CDHR5 locus were genotyped using TaqMan allelic discrimination technology.
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.
Sawalha et al., Oklahoma City, United States. In Arthritis Rheum, 2011
The loci examined included PTPN22, FCGR2A, TNFSF4, STAT4, CTLA4, PDCD1, PXK, BANK1, MSH5 (HLA region), CFB (HLA region), C8orf13-BLK region, MBL2, KIAA1542, ITGAM, and MECP2/IRAK1.
The role of polymorphisms in Toll-like receptors and their associated intracellular signaling genes in measles vaccine immunity.
Poland et al., Rochester, United States. In Hum Genet, 2011
Furthermore, the minor allele of a SNP (rs702966) of the KIAA1542 (IRF7) gene was associated with a dose-related decrease in IFN-γ Elispot responses (38 vs. 26 spot-forming cells per 2 × 10(5) PBMCs, p = 0.00002).
Association of a functional IRF7 variant with systemic lupus erythematosus.
Tsao et al., Shanghai, China. In Arthritis Rheum, 2011
OBJECTIVE: A previous genome-wide association study conducted in a population of European ancestry identified rs4963128, a KIAA1542 single-nucleotide polymorphism (SNP) 23 kb telomeric to IRF7 (the gene for interferon regulatory factor 7 [IRF-7]), to be strongly associated with systemic lupus erythematosus (SLE).
Association of genetic variations in the STAT4 and IRF7/KIAA1542 regions with systemic lupus erythematosus in a Northern Han Chinese population.
Li et al., Beijing, China. In Hum Immunol, 2011
Genome-wide association studies have identified SLE susceptibility variations at the IRF7/KIAA1542 locus and with STAT4 gene in European populations.
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.
Criswell et al., San Francisco, United States. In Plos Genet, 2011
SNPs in the SLE susceptibility loci BANK1, KIAA1542, and UBE2L3 showed evidence of association with anti-dsDNA + SLE and were not associated with anti-dsDNA - SLE.
What can we learn from genetic studies of systemic lupus erythematosus? Implications of genetic heterogeneity among populations in SLE.
Review
Bae et al., Seoul, South Korea. In Lupus, 2010
In addition, there are also several genes and loci that could not be assigned into previous known pathways (KIAA1542, PXK, XKR6, ATG5, etc), providing possible novel mechanisms in SLE.
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
Impact
GeneRIF
Kelly et al., Oklahoma City, United States. In Nat Genet, 2008
study presents four new regions having genetic associations with systemic lupus erythematosus in women of European descent: ITGAM, KIAA1542, PXK and rs10798269
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