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Pogo transposable element with ZNF domain

KIAA0461
The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010] (from NCBI)
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Top mentioned proteins: HSC70, SET, SREBP-2, Oct-1, SP1
Papers on KIAA0461
Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.
Impact
GeneRIF
Obuse et al., Sapporo, Japan. In Nat Cell Biol, 2010
The results reveal POGZ as an essential protein that links HP1alpha dissociation with Aurora B kinase activation during mitosis.
Lens epithelium-derived growth factor/p75 interacts with the transposase-derived DDE domain of PogZ.
GeneRIF
De Rijck et al., Leuven, Belgium. In J Biol Chem, 2009
LEDGF/p75 has a role in DDE domain protein function and interacts with the transposase-derived DDE domain of PogZ
A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.
Brison et al., France. In Mol Cell Biochem, 2000
Host cell factor (HCF-1) and the KIAA0461 gene (encoding a putative Zn-finger protein of unknown function) were both identified through the isolation of three overlapping cDNA clones.
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