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Translocation associated membrane protein 2

KIAA0057, TRAM2, TRAM-like protein
TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004] (from NCBI)
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Papers on KIAA0057
Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2.
GeneRIF
Frenkel et al., Los Angeles, United States. In J Cell Biochem, 2008
Identification of novel Runx2 targets in osteoblasts: cell type-specific BMP-dependent regulation of Tram2.
TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.
GeneRIF
Brenner et al., Tallahassee, United States. In Mol Cell Biol, 2004
TRAM2, as a part of the translocon, is required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon
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