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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Keratocan

Kera, CNA2, CMP2
The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: HAD, ACID, Lum, CAN, cytokeratin
Papers on Kera
Perturbed meibomian gland and tarsal plate morphogenesis by excess TGFα in eyelid stroma.
New
Kao et al., Cincinnati, United States. In Dev Biol, Nov 2015
In this study, we showed that ectopic expression of TGFα in the stroma of Kera-rtTA/tet-O-TGFα bitransgenic mice results in precocious eye opening, abnormal morphogenesis of the meibomian gland, tendon and tarsal plate malformation and epithelium hyperplasia.
Transcriptomic Analysis Reveals Wound Healing of Morus alba Root Extract by Up-Regulating Keratin Filament and CXCL12/CXCR4 Signaling.
New
Jang et al., Seoul, South Korea. In Phytother Res, Aug 2015
It was found that MA extract enhanced proliferation in a dose-dependent manner on Kera-308 cell line, and up-regulated keratin expression including wound-induced Krt6a.
A Novel KERA Mutation in a Case of Autosomal Recessive Cornea Plana With Primary Angle-Closure Glaucoma.
New
Dixit et al., Bhubaneshwar, India. In J Glaucoma, May 2015
In human beings, mutations in keratocan (KERA) are associated with autosomal recessive cornea plana (CNA2), which is characterized by a flattened forward convex curvature of the cornea.
Case report: a novel KERA mutation associated with cornea plana and its predicted effect on protein function.
Tümer et al., Glostrup, Denmark. In Bmc Med Genet, 2014
The recessive form, CNA2, is associated with homozygous or compound heterozygous mutations of the keratocan gene (KERA) on chromosome 12q22.
Role of retrograde trafficking in stress response, host cell interactions, and virulence of Candida albicans.
Filler et al., Torrance, United States. In Eukaryot Cell, 2014
The transcript levels of the calcineurin pathway members CHR11, UTR2, CRZ1, CNA1, and CNA2 were elevated in the vps15Δ/Δ and vps51Δ/Δ mutants.
A role for topographic cues in the organization of collagenous matrix by corneal fibroblasts and stem cells.
Funderburgh et al., Pittsburgh, United States. In Plos One, 2013
After 4 weeks in culture, both cell types upregulated expression of genes marking differentiated keratocytes (KERA, CHST6, AQP1, B3GNT7).
Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.
Hovingh et al., Amsterdam, Netherlands. In Plos One, 2013
Upon sequencing, a non-synonymous variant in KERA (c.920C>G; p.Ser307Cys) was identified.
Bioengineering organized, multilamellar human corneal stromal tissue by growth factor supplementation on highly aligned synthetic substrates.
Wagner et al., Pittsburgh, United States. In Tissue Eng Part A, 2013
hCSSCs differentiated into keratocytes with significant upregulation of the typical gene markers, including KERA, B3GnT7, and CHST6.
Expression of a keratinase (kerA) gene from Bacillus licheniformis in Escherichia coli and characterization of the recombinant enzymes.
Chen et al., China. In Biotechnol Lett, 2013
The gene kerA (1,047 bp) encoding the main keratinase from Bacillus licheniformis was cloned into two conventional vectors, pET30α and pET32α, and expressed in Escherichia coli.
Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance.
Edlind et al., Philadelphia, United States. In Antimicrob Agents Chemother, 2012
Relatedly, FK506 addition or calcineurin gene CMP2 disruption specifically reversed Fks2-mediated resistance of laboratory mutants and clinical isolates.
Codon optimization significantly improves the expression level of a keratinase gene in Pichia pastoris.
Chen et al., China. In Plos One, 2012
The main keratinase (kerA) gene from the Bacillus licheniformis S90 was optimized by two codon optimization strategies and expressed in Pichia pastoris in order to improve the enzyme production compared to the preparations with the native kerA gene.
Differentiation of human embryonic stem cells into cells with corneal keratocyte phenotype.
Funderburgh et al., Pittsburgh, United States. In Plos One, 2012
mRNA for keratocan (KERA), a cornea-specific proteoglycan, was upregulated more than 10,000 fold.
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
Rao et al., Saint Louis, United States. In Front Genet, 2012
Index SNPs in 20 other loci exhibited suggestive (p-value ≤ 1E-06) associations with BP traits by the 1 df interaction test or joint 2 df test, including 3 rare variants, one low-frequency variant, and SNPs near/in genes ESRRG, FAM179A, CRIPT-SOCS5, KAT2B, ADCY2, GLI3, ZNF716, SLIT1, PDE3A, KERA-LUM, RNF219-AS1, CLEC3A, FBXO15, and IGSF5.
Keratocan is expressed by osteoblasts and can modulate osteogenic differentiation.
GeneRIF
Kalajzic et al., Farmington, United States. In Connect Tissue Res, 2011
our results demonstrate the expression of keratocan by osteoblast lineage cells and its ability to modulate osteoblast function.
Linkage of posterior amorphous corneal dystrophy to chromosome 12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN, and EPYC.
GeneRIF
Gorin et al., Los Angeles, United States. In Invest Ophthalmol Vis Sci, 2010
Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region.
Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1.
GeneRIF
Pearlman et al., Cleveland, United States. In J Biol Chem, 2008
lumican and keratocan core proteins bind the CXC chemokine KC during a corneal inflammatory response, indicating that corneal KSPGs mediate neutrophil recruitment to the cornea by regulating chemokine gradient formation.
Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues.
GeneRIF
Little et al., Sydney, Australia. In Arthritis Res Ther, 2007
Multiple core-protein species were detected for decorin, biglycan, lumican and keratocan in the degenerate osteoarthritic articular cartilage and menisci.
Study of p.N247S KERA mutation in a British family with cornea plana.
GeneRIF
Bhattacharya et al., London, United Kingdom. In Mol Vis, 2006
This is the first description of recessive cornea plana in a white British family and it is the second report on the p.N247S change in the KERA gene.
Ocular surface tissue morphogenesis in normal and disease states revealed by genetically modified mice.
Review
Kao, Cincinnati, United States. In Cornea, 2006
Toward this goal, we prepared 2 groups of genetically modified mouse lines: (1) transgenesis using keratocan promoter was used to create Kera-rtTA mice (doxycycline-inducible mice) and Cre-LoxP system (ie, Kera-Cre mice; conditional gene ablation in neural crest cell lineage and adult stromal keratocyte) and Kera-CrePR mice (RU-486 inducible); and (2) knock-in strategies were used to create Krt12-rtTA mice (doxycycline inducible), Krt12-Cre mice (conditional ablation in corneal epithelium), and Krt12rtTA-tet-O-Cre mice (doxycycline-inducible corneal epithelium-specific gene ablation).
Mutations in KERA, encoding keratocan, cause cornea plana.
Impact
de la Chapelle et al., Columbus, United States. In Nat Genet, 2000
We cloned two additional SLRP genes highly expressed in cornea: KERA (encoding keratocan) in 12q and OGN (encoding osteoglycin) in 9q.
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