Effect of diosmin on the intestinal absorption and pharmacokinetics of fexofenadine in rats.
Warangal, India. In Pharmacol Rep, Apr 2015
In comparison with control, pretreatment with diosmin significantly increased peak plasma concentration (Cmax) and area under the concentration-time curve (AUC), while there was no significant change was observed in half life (T1/2), time to reach peak plasma concentration (Tmax) and elimination rate constant (Kel) of fexofenadine.
Semi-mechanistic modelling and simulation of inhibition of platelet aggregation by antiplatelet agents.
Taejŏn, South Korea. In Basic Clin Pharmacol Toxicol, 2014
Time courses of plasma concentrations of the antiplatelet agents and their platelet aggregation effects were analysed using ADPAT V. Pharmacokinetic profiles were fitted to an extended parent-metabolite pharmacokinetic model, based on a two-compartment model, and the pharmacodynamic effects of the agents were fitted to a platelet aggregation effect model that consisted of the following parameters: Ks , the active-form platelet synthesis rate constant; K, the apparent reaction rate constant of the agent and active-form platelets; Kel-PRP , the apparent rate constant of platelets; and ε, an intrinsic activity parameter.
Insights into the structure and function of membrane polypeptides carrying blood group antigens.
Paris, France. In Vox Sang, 1997
This review will focus on selected blood groups systems (RH, JK, FY, LU, LW, KEL and XK) which are representative of these classes of molecules, in order to illustrate how these studies may bring new information on common and variant phenotypes and for understanding both the mechanisms of tissue specific expression and the potential function of these antigens, particularly those expressed in nonerythroid lineage.
[A molecular approach to the structure, polymorphism and function of blood groups].
Paris, France. In Transfus Clin Biol, 1995
Most have been cloned and characterized recently, for instance MN antigens (glycophorin A), Ss antigens (glycophorin B), Gerbich antigens (glycophorins C and D) and antigens encoded by the RH, LW, KEL, FY, JK, XG, LU and XK loci.